Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360615048> ?p ?o ?g. }
- W4360615048 endingPage "774" @default.
- W4360615048 startingPage "774" @default.
- W4360615048 abstract "DNA polymerase delta is the primary polymerase that is involved in undamaged nuclear lagging strand DNA replication. Our mass-spectroscopic analysis has revealed that the human DNA polymerase δ is acetylated on subunits p125, p68, and p12. Using substrates that simulate Okazaki fragment intermediates, we studied alterations in the catalytic properties of acetylated polymerase and compared it to the unmodified form. The current data show that the acetylated form of human pol δ displays a higher polymerization activity compared to the unmodified form of the enzyme. Additionally, acetylation enhances the ability of the polymerase to resolve complex structures such as G-quadruplexes and other secondary structures that might be present on the template strand. More importantly, the ability of pol δ to displace a downstream DNA fragment is enhanced upon acetylation. Our current results suggest that acetylation has a profound effect on the activity of pol δ and supports the hypothesis that acetylation may promote higher-fidelity DNA replication." @default.
- W4360615048 created "2023-03-24" @default.
- W4360615048 creator A5005315226 @default.
- W4360615048 creator A5007071794 @default.
- W4360615048 creator A5021657789 @default.
- W4360615048 creator A5031952567 @default.
- W4360615048 creator A5058574520 @default.
- W4360615048 date "2023-03-23" @default.
- W4360615048 modified "2023-09-30" @default.
- W4360615048 title "DNA Polymerase Delta Exhibits Altered Catalytic Properties on Lysine Acetylation" @default.
- W4360615048 cites W1605838085 @default.
- W4360615048 cites W1887262817 @default.
- W4360615048 cites W1970916666 @default.
- W4360615048 cites W1973440927 @default.
- W4360615048 cites W1974515407 @default.
- W4360615048 cites W1980116731 @default.
- W4360615048 cites W1980480427 @default.
- W4360615048 cites W1988914928 @default.
- W4360615048 cites W1989379056 @default.
- W4360615048 cites W1990904040 @default.
- W4360615048 cites W1991298183 @default.
- W4360615048 cites W1998388897 @default.
- W4360615048 cites W1998590756 @default.
- W4360615048 cites W2004335766 @default.
- W4360615048 cites W2009826707 @default.
- W4360615048 cites W2019722560 @default.
- W4360615048 cites W2020626331 @default.
- W4360615048 cites W2036743626 @default.
- W4360615048 cites W2038917196 @default.
- W4360615048 cites W2039114116 @default.
- W4360615048 cites W2043274355 @default.
- W4360615048 cites W2046610039 @default.
- W4360615048 cites W2050913592 @default.
- W4360615048 cites W2052771249 @default.
- W4360615048 cites W2053213954 @default.
- W4360615048 cites W2054615119 @default.
- W4360615048 cites W2054877486 @default.
- W4360615048 cites W2055869110 @default.
- W4360615048 cites W2056375209 @default.
- W4360615048 cites W2059184834 @default.
- W4360615048 cites W2066261076 @default.
- W4360615048 cites W2089594949 @default.
- W4360615048 cites W2092722802 @default.
- W4360615048 cites W2094680135 @default.
- W4360615048 cites W2095206600 @default.
- W4360615048 cites W2108385007 @default.
- W4360615048 cites W2111202021 @default.
- W4360615048 cites W2111958293 @default.
- W4360615048 cites W2125915154 @default.
- W4360615048 cites W2126969678 @default.
- W4360615048 cites W2127411392 @default.
- W4360615048 cites W2134095164 @default.
- W4360615048 cites W2137855486 @default.
- W4360615048 cites W2138866614 @default.
- W4360615048 cites W2143538182 @default.
- W4360615048 cites W2150867189 @default.
- W4360615048 cites W2151071075 @default.
- W4360615048 cites W2154093655 @default.
- W4360615048 cites W2161232591 @default.
- W4360615048 cites W2161513801 @default.
- W4360615048 cites W2169543816 @default.
- W4360615048 cites W2169745877 @default.
- W4360615048 cites W2318272234 @default.
- W4360615048 cites W2558513990 @default.
- W4360615048 cites W2570706752 @default.
- W4360615048 cites W2724249599 @default.
- W4360615048 cites W2811227283 @default.
- W4360615048 cites W2963425955 @default.
- W4360615048 cites W3004614784 @default.
- W4360615048 cites W3009470867 @default.
- W4360615048 cites W3085850424 @default.
- W4360615048 doi "https://doi.org/10.3390/genes14040774" @default.
- W4360615048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37107532" @default.
- W4360615048 hasPublicationYear "2023" @default.
- W4360615048 type Work @default.
- W4360615048 citedByCount "1" @default.
- W4360615048 countsByYear W43606150482023 @default.
- W4360615048 crossrefType "journal-article" @default.
- W4360615048 hasAuthorship W4360615048A5005315226 @default.
- W4360615048 hasAuthorship W4360615048A5007071794 @default.
- W4360615048 hasAuthorship W4360615048A5021657789 @default.
- W4360615048 hasAuthorship W4360615048A5031952567 @default.
- W4360615048 hasAuthorship W4360615048A5058574520 @default.
- W4360615048 hasBestOaLocation W43606150481 @default.
- W4360615048 hasConcept C104317684 @default.
- W4360615048 hasConcept C11305352 @default.
- W4360615048 hasConcept C119157956 @default.
- W4360615048 hasConcept C131140672 @default.
- W4360615048 hasConcept C153911025 @default.
- W4360615048 hasConcept C156719811 @default.
- W4360615048 hasConcept C164965036 @default.
- W4360615048 hasConcept C185592680 @default.
- W4360615048 hasConcept C2756471 @default.
- W4360615048 hasConcept C31254050 @default.
- W4360615048 hasConcept C49105822 @default.
- W4360615048 hasConcept C552990157 @default.
- W4360615048 hasConcept C55493867 @default.
- W4360615048 hasConcept C73573662 @default.