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• W4360619150 abstract "Type 2 diabetes mellitus (T2DM), a major driver of mortality worldwide, is more likely to develop other cardiometabolic risk factors, ultimately leading to diabetes-related mortality. Although a set of measures including lifestyle intervention and antidiabetic drugs have been proposed to manage T2DM, problems associated with potential side-effects and drug resistance are still unresolved. Pharmacomicrobiomics is an emerging field that investigates the interactions between the gut microbiome and drug response variability or drug toxicity. In recent years, increasing evidence supports that the gut microbiome, as the second genome, can serve as an attractive target for improving drug efficacy and safety by manipulating its composition. In this review, we outline the different composition of gut microbiome in T2DM and highlight how these microbiomes actually play a vital role in its development. Furthermore, we also investigate current state-of-the-art knowledge on pharmacomicrobiomics and microbiome's role in modulating the response to antidiabetic drugs, as well as provide innovative potential personalized treatments, including approaches for predicting response to treatment and for modulating the microbiome to improve drug efficacy or reduce drug toxicity." @default.
• W4360619150 created "2023-03-24" @default.
• W4360619150 creator A5010677263 @default.
• W4360619150 creator A5019335381 @default.
• W4360619150 creator A5038265266 @default.
• W4360619150 creator A5048134967 @default.
• W4360619150 creator A5075234130 @default.
• W4360619150 date "2023-03-23" @default.
• W4360619150 modified "2023-09-26" @default.
• W4360619150 title "Pharmacomicrobiomics and type 2 diabetes mellitus: A novel perspective towards possible treatment" @default.
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