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• W4360754216 endingPage "6846" @default.
• W4360754216 startingPage "6837" @default.
• W4360754216 abstract "Theα 2C subclass of adrenergic receptor (α 2C -AR) mediates some of the antinociceptive actions of norepinephrine in the spinal cord. Axon terminals, which possess this receptor, are concentrated in the superficial dorsal horn and originate from spinal interneurons. We performed a series of combined tract-tracing and immunocytochemical studies to determine whether α 2C -AR-immunoreactive axons target projection neurons that possess the neurokinin-1 (NK-1) receptor because such cells are likely to transmit nociceptive information to the brain. Spinomedullary neurons were labeled by stereotaxic injection of the B-subunit of cholera toxin (CTb) into the caudal ventrolateral medulla of three anesthetized adult rats. After 3 d, the animals were anesthetized again and fixed by perfusion. Sections were cut from midlumbar segments and reacted with antibodies to reveal α 2C -ARs, CTb, and NK-1 receptors. Retrogradely labeled neurons possessing the NK-1 receptor ( n = 45) were examined with confocal microscopy to investigate their relationship with α 2C -AR-immunoreactive axons. Numerous α 2C -AR axons were apposed to cell bodies and proximal dendrites of cells in lamina I and also to distal dendrites that originate from labeled cell bodies in lamina III/IV. A combined confocal and electron microscopic method confirmed that these appositions were synaptic. Additional experiments showed that virtually all α 2C -AR terminals in contact with labeled cells are also immunoreactive for the vesicular glutamate transporter 2 and therefore are glutamatergic. These data suggest that norepinephrine can modulate excitatory synaptic transmission from spinal interneurons to projection cells by acting at α 2C -ARs. This could be one of the mechanisms that underlie the antinociceptive actions of norepinephrine." @default.
• W4360754216 created "2023-03-25" @default.
• W4360754216 creator A5048235651 @default.
• W4360754216 creator A5070722958 @default.
• W4360754216 date "2003-07-30" @default.
• W4360754216 modified "2023-10-14" @default.
• W4360754216 title "Neurokinin-1 Projection Cells in the Rat Dorsal Horn Receive Synaptic Contacts from Axons That Possess α_2C-Adrenergic Receptors" @default.
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• W4360754216 doi "https://doi.org/10.1523/jneurosci.23-17-06837.2003" @default.
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