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- W4360754881 abstract "Four patients each had a single subcutaneous nodule at the site of a previous vaccine injection; three after injection of diphtheria, tetanus, and pertussis vaccination and one after tetanus toxoid vaccination. Presentation was with a mass 4–22 months after vaccination at the site of injection. Histologically, three patients had a necrotizing granulomatus reaction with a surrounding infiltrate of lymphocytes, plasma cells, histiocytes, and associated fibrosis. The fourth patient demonstrated a lymphohistiocytic reaction with a predominance of histiocytic cells as well as associated plasma cells, fibroblasts, and fibrosis. The lymphoid infiltration in these reactions showed a predominance of T-lymphocytes over B-lymphocytes. Aluminum was demonstrated in necrotic foci, inflammatory stroma, and the granular cytoplasm of histiocytes with the aid of solochrome azurine and solochrome cyanine stains as well as by energy-dispersive x-ray microanalysis. The reactions are thought to be immunologic (hypersensitivity) reactions associated with the aluminum contents of the preparation." @default.
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- W4360754881 date "1993-05-01" @default.
- W4360754881 modified "2023-10-16" @default.
- W4360754881 title "Postimmunization (Vaccination) Injection-Site Reactions" @default.
- W4360754881 doi "https://doi.org/10.1097/00000478-199305000-00012" @default.
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