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- W4360774906 abstract "Background: The long-term complications associated with diabetes can be delayed by early screening and diagnosis. This requires venipuncture at regular intervals of time which causes anxiety and discomfort to the patient discouraging the patient further. Studies are being conducted to develop saliva as a tool for the screening and monitoring of systemic diseases. It is reported that resistin along with other adipokines functions as a pro-inflammatory cytokine, promotes insulin resistance (IR), and can be detected in the saliva of healthy adults. Aim: The aim of this study is to compare and correlate the serum and salivary levels of resistin in normal and diabetic patients. Furthermore, to establish salivary resistin as a tool to assess IR and inflammatory and glycemic status in type 2 diabetes mellitus (DM) patients, its correlation with homeostatic model assessment-IR (HOMA-IR), C-reactive protein (CRP), and glycated hemoglobin (HbA1c) along with fasting blood sugar is also studied. Materials and Methods: Blood glucose, HbA1c, and resistin were estimated by glucose oxidase–peroxidase method, high-performance liquid chromatography, and enzyme-linked immunosorbent assay, respectively. CRP was estimated using immunoturbidimetry and fasting insulin by chemiluminescence. HOMA-IR was calculated from basal (fasting) glucose and fasting insulin concentrations. Statistical analysis was done on SPSS 16. Results: The results show a strong and significant correlation of salivary resistin with serum resistin, HOMA IR, and CRP levels. The salivary resistin levels also correlated with fasting plasma glucose and HbA1c. Conclusion: Salivary resistin can be used as an effective tool for monitoring the different attributes of diabetes. Standardization of the techniques for the estimation of salivary resistin and setting up a reference range will also make it useful to surveil the prognosis of DM." @default.
- W4360774906 created "2023-03-25" @default.
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- W4360774906 date "2020-01-01" @default.
- W4360774906 modified "2023-09-27" @default.
- W4360774906 title "Salivary resistin: A noninvasive mirror of attributes of type 2 diabetes mellitus" @default.
- W4360774906 doi "https://doi.org/10.4103/jdmimsu.jdmimsu_378_20" @default.
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