FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360801367> ?p ?o ?g. }

• W4360801367 abstract "Background Triple-negative breast cancer (TNBC) is a highly aggressive disease that lacks therapeutic targets and prognostic biomarkers. Claudin-1 is a well-described tight junction protein with prognostic value in many human cancers. Aims The need for the discovery of biomarkers of TNBC disease was a major reason for this study. Claudin-1 is a tight junction protein that has shown promising results in the prognosis and management of cancer in general. In the breast, claudin-1 expression and significance have shown variable results, especially in TNBC patients. Our study assessed expression of claudin-1 in a group of TNBC patients, and correlated this expression with clinical-pathological parameters, and with the expression of β-catenin. Materials and methods Tissues from a group of 52 TNBC patients were retrieved from the archives of the community hospital. All related information including demographical, pathologic and clinical data were retrieved. Immunohistochemistry assays of a rabbit polyclonal antibody anti-human claudin-1 were applied using the avidin-biotin peroxidase methodology. Results A statistically significant majority of TNBC cases positively expressed claudin-1 (81%, χ2=13.705; p<0.001). Most TNBC cases had grade 2 β-catenin expression (77.5%; p<0.001), and positive expression for claudin-1 correlated with that of β-catenin (χ2= 23.757; p<0.001). Claudin-1 and β-catenin expressions within tumour cells shared several features including absent or weakness of membranous expression, and redistribution of both proteins to the cytoplasm of tumour cells, and in some cases to the nuclei of these cells. Claudin-1 expression also correlates with adverse survival outcomes, where only four of 20 claudin-1-positive patients who received neo-adjuvant chemotherapy (NAC) achieved pathological complete response (pCR). Conclusions The above presents a complex role of claudin-1 in TNBC patients. In this study, claudin-1 expression was associated with poor prognostic features including invasion, metastases and adverse clinical outcomes. Claudin-1 expression in TNBC correlated with the expression of β-catenin, an important oncogene and a major contributor to the epithelial mesenchymal transition (EMT) phenomenon. Overall, the above results may serve as an impetus for further mechanistic studies to assess the exact role of claudin-1 in TNBC and its possible use in the management of this subset of breast cancer." @default.
• W4360801367 created "2023-03-25" @default.
• W4360801367 creator A5031669901 @default.
• W4360801367 creator A5046484119 @default.
• W4360801367 creator A5062037389 @default.
• W4360801367 creator A5068986604 @default.
• W4360801367 creator A5079923678 @default.
• W4360801367 date "2023-03-24" @default.
• W4360801367 modified "2023-09-26" @default.
• W4360801367 title "Detection of Increased Expression of Claudin-1 in Triple-Negative Breast Cancer: Analysis and Clinical-Pathological Correlation" @default.
• W4360801367 cites W19217428 @default.
• W4360801367 cites W1966683700 @default.
• W4360801367 cites W1974853120 @default.
• W4360801367 cites W2024487262 @default.
• W4360801367 cites W2024641771 @default.
• W4360801367 cites W2034336979 @default.
• W4360801367 cites W2034626424 @default.
• W4360801367 cites W2036298639 @default.
• W4360801367 cites W2045216597 @default.
• W4360801367 cites W2062072171 @default.
• W4360801367 cites W2074605890 @default.
• W4360801367 cites W2105772211 @default.
• W4360801367 cites W2106517313 @default.
• W4360801367 cites W2121138594 @default.
• W4360801367 cites W2147278996 @default.
• W4360801367 cites W2157285286 @default.
• W4360801367 cites W2159407899 @default.
• W4360801367 cites W2186784163 @default.
• W4360801367 cites W2800158081 @default.
• W4360801367 cites W2901812837 @default.
• W4360801367 cites W2909590780 @default.
• W4360801367 cites W2971485375 @default.
• W4360801367 cites W2980493401 @default.
• W4360801367 cites W2989855230 @default.
• W4360801367 cites W2990052933 @default.
• W4360801367 cites W2990302286 @default.
• W4360801367 cites W2992783149 @default.
• W4360801367 cites W2995404874 @default.
• W4360801367 cites W2995472387 @default.
• W4360801367 cites W2997690955 @default.
• W4360801367 cites W2997890793 @default.
• W4360801367 cites W3000382063 @default.
• W4360801367 cites W3004341557 @default.
• W4360801367 cites W3008426816 @default.
• W4360801367 cites W3082027487 @default.
• W4360801367 cites W3125581240 @default.
• W4360801367 cites W3212334348 @default.
• W4360801367 cites W3215092418 @default.
• W4360801367 cites W4312187010 @default.
• W4360801367 doi "https://doi.org/10.7759/cureus.36648" @default.
• W4360801367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102018" @default.
• W4360801367 hasPublicationYear "2023" @default.
• W4360801367 type Work @default.
• W4360801367 citedByCount "0" @default.
• W4360801367 crossrefType "journal-article" @default.
• W4360801367 hasAuthorship W4360801367A5031669901 @default.
• W4360801367 hasAuthorship W4360801367A5046484119 @default.
• W4360801367 hasAuthorship W4360801367A5062037389 @default.
• W4360801367 hasAuthorship W4360801367A5068986604 @default.
• W4360801367 hasAuthorship W4360801367A5079923678 @default.
• W4360801367 hasBestOaLocation W43608013671 @default.
• W4360801367 hasConcept C121608353 @default.
• W4360801367 hasConcept C126322002 @default.
• W4360801367 hasConcept C142724271 @default.
• W4360801367 hasConcept C143998085 @default.
• W4360801367 hasConcept C177779419 @default.
• W4360801367 hasConcept C204232928 @default.
• W4360801367 hasConcept C207886595 @default.
• W4360801367 hasConcept C2780110267 @default.
• W4360801367 hasConcept C502942594 @default.
• W4360801367 hasConcept C51872919 @default.
• W4360801367 hasConcept C530470458 @default.
• W4360801367 hasConcept C63363279 @default.
• W4360801367 hasConcept C71924100 @default.
• W4360801367 hasConcept C86803240 @default.
• W4360801367 hasConcept C95444343 @default.
• W4360801367 hasConceptScore W4360801367C121608353 @default.
• W4360801367 hasConceptScore W4360801367C126322002 @default.
• W4360801367 hasConceptScore W4360801367C142724271 @default.
• W4360801367 hasConceptScore W4360801367C143998085 @default.
• W4360801367 hasConceptScore W4360801367C177779419 @default.
• W4360801367 hasConceptScore W4360801367C204232928 @default.
• W4360801367 hasConceptScore W4360801367C207886595 @default.
• W4360801367 hasConceptScore W4360801367C2780110267 @default.
• W4360801367 hasConceptScore W4360801367C502942594 @default.
• W4360801367 hasConceptScore W4360801367C51872919 @default.
• W4360801367 hasConceptScore W4360801367C530470458 @default.
• W4360801367 hasConceptScore W4360801367C63363279 @default.
• W4360801367 hasConceptScore W4360801367C71924100 @default.
• W4360801367 hasConceptScore W4360801367C86803240 @default.
• W4360801367 hasConceptScore W4360801367C95444343 @default.
• W4360801367 hasLocation W43608013671 @default.
• W4360801367 hasLocation W43608013672 @default.
• W4360801367 hasLocation W43608013673 @default.
• W4360801367 hasOpenAccess W4360801367 @default.
• W4360801367 hasPrimaryLocation W43608013671 @default.
• W4360801367 hasRelatedWork W1999292713 @default.
• W4360801367 hasRelatedWork W2317787856 @default.
• W4360801367 hasRelatedWork W2363661003 @default.
• W4360801367 hasRelatedWork W2368027314 @default.

• next