Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360809087> ?p ?o ?g. }
- W4360809087 abstract "In the past decades, immunotherapy has achieved a series of clinical successes in the field of cancer. However, existing therapeutic options usually show a low immune response to solid tumors caused by immunosuppressive “cold” tumor microenvironment (TME). Several types of proinflammatory regulated cell death (RCD), mainly including ferroptosis and pyroptosis, have been studied recently, which can provide proinflammatory signals and immunogenicity necessary for remodeling TME and activating an antitumor immune response. A variety of chemotherapeutic drugs are proven to be effective in the proinflammatory RCD induction of tumor cells, but several adverse effects and intrinsic drug resistance usually occur in the therapeutic process, greatly hindering their further clinical application. The emerging organic photosensitizer (PS)-based materials open new possibilities to effectively activate proinflammatory RCD through precise spatiotemporal regulation of intracellular reactive oxygen species-associated signaling pathways, which can overcome many challenges encountered in current proinflammatory RCD-mediated immunotherapy. In this review, the recent design strategies of PS probes are detailly summarized and their potential advantages for tumor-specific proinflammatory RCD induction are discussed. Moreover, the representative examples in cancer immunotherapy are highlighted and future perspectives in this emerging field are proposed." @default.
- W4360809087 created "2023-03-25" @default.
- W4360809087 creator A5003599939 @default.
- W4360809087 creator A5038620471 @default.
- W4360809087 creator A5047736726 @default.
- W4360809087 creator A5049078993 @default.
- W4360809087 creator A5077382421 @default.
- W4360809087 creator A5087017921 @default.
- W4360809087 date "2023-03-24" @default.
- W4360809087 modified "2023-09-28" @default.
- W4360809087 title "Recent Organic Photosensitizer Designs for Evoking Proinflammatory Regulated Cell Death in Antitumor Immunotherapy" @default.
- W4360809087 cites W1904885158 @default.
- W4360809087 cites W1997183854 @default.
- W4360809087 cites W2026889493 @default.
- W4360809087 cites W2042699075 @default.
- W4360809087 cites W2056042156 @default.
- W4360809087 cites W2102891867 @default.
- W4360809087 cites W2113839377 @default.
- W4360809087 cites W2116415854 @default.
- W4360809087 cites W2125988618 @default.
- W4360809087 cites W2143772132 @default.
- W4360809087 cites W2145334000 @default.
- W4360809087 cites W2183914927 @default.
- W4360809087 cites W2281508338 @default.
- W4360809087 cites W2500786171 @default.
- W4360809087 cites W2568082326 @default.
- W4360809087 cites W2608687752 @default.
- W4360809087 cites W2610420640 @default.
- W4360809087 cites W2621295461 @default.
- W4360809087 cites W2762087180 @default.
- W4360809087 cites W2802831093 @default.
- W4360809087 cites W2805542742 @default.
- W4360809087 cites W2807582167 @default.
- W4360809087 cites W2887464310 @default.
- W4360809087 cites W2892740414 @default.
- W4360809087 cites W2945161487 @default.
- W4360809087 cites W2954162996 @default.
- W4360809087 cites W2989083977 @default.
- W4360809087 cites W2995900562 @default.
- W4360809087 cites W3011061347 @default.
- W4360809087 cites W3016223657 @default.
- W4360809087 cites W3016811071 @default.
- W4360809087 cites W3017776795 @default.
- W4360809087 cites W3018133722 @default.
- W4360809087 cites W3030553520 @default.
- W4360809087 cites W3032712286 @default.
- W4360809087 cites W3038105921 @default.
- W4360809087 cites W3080945733 @default.
- W4360809087 cites W3087044209 @default.
- W4360809087 cites W3090282367 @default.
- W4360809087 cites W3099307826 @default.
- W4360809087 cites W3104958039 @default.
- W4360809087 cites W3106793978 @default.
- W4360809087 cites W3109474584 @default.
- W4360809087 cites W3119217097 @default.
- W4360809087 cites W3125007765 @default.
- W4360809087 cites W3127201913 @default.
- W4360809087 cites W3128195390 @default.
- W4360809087 cites W3128646645 @default.
- W4360809087 cites W3133029280 @default.
- W4360809087 cites W3137943095 @default.
- W4360809087 cites W3142080073 @default.
- W4360809087 cites W3153618119 @default.
- W4360809087 cites W3158206585 @default.
- W4360809087 cites W3160048790 @default.
- W4360809087 cites W3164825503 @default.
- W4360809087 cites W3175275490 @default.
- W4360809087 cites W3180091720 @default.
- W4360809087 cites W3201831068 @default.
- W4360809087 cites W3204360553 @default.
- W4360809087 cites W3208991717 @default.
- W4360809087 cites W3212243061 @default.
- W4360809087 cites W3212894081 @default.
- W4360809087 cites W3213407578 @default.
- W4360809087 cites W3214918102 @default.
- W4360809087 cites W4200130267 @default.
- W4360809087 cites W4220988416 @default.
- W4360809087 cites W4225982937 @default.
- W4360809087 cites W4229581881 @default.
- W4360809087 cites W4281290139 @default.
- W4360809087 cites W4281704317 @default.
- W4360809087 cites W4282962800 @default.
- W4360809087 cites W4283156085 @default.
- W4360809087 cites W4283701798 @default.
- W4360809087 cites W4285109551 @default.
- W4360809087 cites W4288057867 @default.
- W4360809087 cites W4289654554 @default.
- W4360809087 cites W4291168357 @default.
- W4360809087 cites W4293791085 @default.
- W4360809087 cites W4294069016 @default.
- W4360809087 cites W4294782885 @default.
- W4360809087 cites W4298009555 @default.
- W4360809087 cites W4307770948 @default.
- W4360809087 cites W4310467745 @default.
- W4360809087 cites W4316362577 @default.
- W4360809087 doi "https://doi.org/10.1002/smtd.202201614" @default.
- W4360809087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36960933" @default.
- W4360809087 hasPublicationYear "2023" @default.
- W4360809087 type Work @default.
- W4360809087 citedByCount "1" @default.