FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360815328> ?p ?o ?g. }

• W4360815328 endingPage "1266" @default.
• W4360815328 startingPage "1259" @default.
• W4360815328 abstract "Abstract Glutamate receptor, ionotropic, kainate 5 (GRIK5) is a member of glutamate receptors participating, and the kainate receptor family has been proved to regulate cell proliferation and transformation. Our study aimed at exploring the role of GRIK5 in colon tumor progression. Three hundred and ninety eight colon cancer patients in The Cancer Genome Atlas Program (TCGA) data set and 26 clinical colon cancer patients were included for GRIK5 expression and prognosis analysis. GRIK5 overexpressed HCT116 and CT26 cell lines were established for cell proliferation and Transwell assay. Western blot analysis and immunostaining assay was conducted to evaluate the activation of activation of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cell adhesion molecular 3 (CADM3) signaling in cell lines and tumor tissues. Subcutaneous CT26‐bearing mice model was established to examine GRIK5‐induced tumor growth and metastasis in vivo. Our study identified GRIK5 to be upregulated in patients with colon cancer, and higher GRIK5 levels correlated with the poor overall survival in patients. In vitro, GRIK5 overexpression markedly enhanced the proliferative properties and aggressive behaviors of colon cancer cells. Mechanistically, GRIK5 induced the activation of cAMP/PKA signaling, proceeded with augmented CADM3 expression, eventually resulting in sustained tumor growth. GRIK5 was a crucial scaffold in enabling colon cancer growth and metastasis, which offered a promising target for therapeutic manipulation of colon cancer." @default.
• W4360815328 created "2023-03-25" @default.
• W4360815328 creator A5007744751 @default.
• W4360815328 creator A5015826438 @default.
• W4360815328 creator A5016937419 @default.
• W4360815328 creator A5025970081 @default.
• W4360815328 creator A5030342634 @default.
• W4360815328 creator A5037540468 @default.
• W4360815328 creator A5078498216 @default.
• W4360815328 creator A5080576812 @default.
• W4360815328 creator A5083814134 @default.
• W4360815328 creator A5087610827 @default.
• W4360815328 date "2023-04-25" @default.
• W4360815328 modified "2023-09-27" @default.
• W4360815328 title "GRIK5 stimulates colon cancer growth and metastasis through cAMP/PKA/CADM3 signaling" @default.
• W4360815328 cites W1216912431 @default.
• W4360815328 cites W1966280980 @default.
• W4360815328 cites W1976518836 @default.
• W4360815328 cites W1984941194 @default.
• W4360815328 cites W1998532843 @default.
• W4360815328 cites W2034649274 @default.
• W4360815328 cites W2058658179 @default.
• W4360815328 cites W2059944523 @default.
• W4360815328 cites W2062657498 @default.
• W4360815328 cites W2073232199 @default.
• W4360815328 cites W2077776183 @default.
• W4360815328 cites W2158685104 @default.
• W4360815328 cites W2338843409 @default.
• W4360815328 cites W2556150593 @default.
• W4360815328 cites W2596889284 @default.
• W4360815328 cites W2796153225 @default.
• W4360815328 cites W2805089662 @default.
• W4360815328 cites W2889243432 @default.
• W4360815328 cites W2939346240 @default.
• W4360815328 cites W2957009233 @default.
• W4360815328 cites W3107791012 @default.
• W4360815328 cites W3118536823 @default.
• W4360815328 cites W3128646645 @default.
• W4360815328 cites W3168326471 @default.
• W4360815328 cites W4206497650 @default.
• W4360815328 cites W4211168195 @default.
• W4360815328 cites W4245766190 @default.
• W4360815328 doi "https://doi.org/10.1002/cbin.12022" @default.
• W4360815328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36959746" @default.
• W4360815328 hasPublicationYear "2023" @default.
• W4360815328 type Work @default.
• W4360815328 citedByCount "0" @default.
• W4360815328 crossrefType "journal-article" @default.
• W4360815328 hasAuthorship W4360815328A5007744751 @default.
• W4360815328 hasAuthorship W4360815328A5015826438 @default.
• W4360815328 hasAuthorship W4360815328A5016937419 @default.
• W4360815328 hasAuthorship W4360815328A5025970081 @default.
• W4360815328 hasAuthorship W4360815328A5030342634 @default.
• W4360815328 hasAuthorship W4360815328A5037540468 @default.
• W4360815328 hasAuthorship W4360815328A5078498216 @default.
• W4360815328 hasAuthorship W4360815328A5080576812 @default.
• W4360815328 hasAuthorship W4360815328A5083814134 @default.
• W4360815328 hasAuthorship W4360815328A5087610827 @default.
• W4360815328 hasBestOaLocation W43608153281 @default.
• W4360815328 hasConcept C121608353 @default.
• W4360815328 hasConcept C126322002 @default.
• W4360815328 hasConcept C204232928 @default.
• W4360815328 hasConcept C2779013556 @default.
• W4360815328 hasConcept C4224716 @default.
• W4360815328 hasConcept C502942594 @default.
• W4360815328 hasConcept C526805850 @default.
• W4360815328 hasConcept C55493867 @default.
• W4360815328 hasConcept C62112901 @default.
• W4360815328 hasConcept C62478195 @default.
• W4360815328 hasConcept C71924100 @default.
• W4360815328 hasConcept C86803240 @default.
• W4360815328 hasConcept C95444343 @default.
• W4360815328 hasConceptScore W4360815328C121608353 @default.
• W4360815328 hasConceptScore W4360815328C126322002 @default.
• W4360815328 hasConceptScore W4360815328C204232928 @default.
• W4360815328 hasConceptScore W4360815328C2779013556 @default.
• W4360815328 hasConceptScore W4360815328C4224716 @default.
• W4360815328 hasConceptScore W4360815328C502942594 @default.
• W4360815328 hasConceptScore W4360815328C526805850 @default.
• W4360815328 hasConceptScore W4360815328C55493867 @default.
• W4360815328 hasConceptScore W4360815328C62112901 @default.
• W4360815328 hasConceptScore W4360815328C62478195 @default.
• W4360815328 hasConceptScore W4360815328C71924100 @default.
• W4360815328 hasConceptScore W4360815328C86803240 @default.
• W4360815328 hasConceptScore W4360815328C95444343 @default.
• W4360815328 hasIssue "7" @default.
• W4360815328 hasLocation W43608153281 @default.
• W4360815328 hasLocation W43608153282 @default.
• W4360815328 hasOpenAccess W4360815328 @default.
• W4360815328 hasPrimaryLocation W43608153281 @default.
• W4360815328 hasRelatedWork W1499339123 @default.
• W4360815328 hasRelatedWork W1970423756 @default.
• W4360815328 hasRelatedWork W2351502039 @default.
• W4360815328 hasRelatedWork W2392730113 @default.
• W4360815328 hasRelatedWork W3004259476 @default.
• W4360815328 hasRelatedWork W3032265334 @default.
• W4360815328 hasRelatedWork W3032784534 @default.
• W4360815328 hasRelatedWork W3173207637 @default.

• next