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- W4360816963 abstract "Vaccination is the most important way of population protection from life-threatening pathogenic infections. However, its efficiency is frequently compromised by a failure of strong antigen presentation and immune activation. Herein, we developed virus-like magnetic mesoporous silica nanoparticles as a universal vaccination platform (termed MagParV) for preventing pathogenic infections. This platform was constructed by integrating synthetic biology-based endoplasmic reticulum-targeting vesicles with magnetic mesoporous silica particles. This platform exhibited high antigen-loading capacity, strongly targeting the endoplasmic reticulum and promoting antigen presentation in dendritic cells. After prime-boost vaccination, the antigen-loading MagParV with AMF drastically elicited specific antibody production against corresponding antigens of fungal, bacterial, and viral pathogens. A systemic infection model further revealed that the platform effectively protected the mice from severe fungal systemic infections. This study realized synthetic biology-facilitated green manufacturing of vaccines, which is promising for magnetism-activated vaccination against different kinds of pathogenic infections." @default.
- W4360816963 created "2023-03-25" @default.
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- W4360816963 date "2023-03-24" @default.
- W4360816963 modified "2023-10-17" @default.
- W4360816963 title "Virus-like Magnetic Mesoporous Silica Particles as a Universal Vaccination Platform against Pathogenic Infections" @default.
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- W4360816963 doi "https://doi.org/10.1021/acsnano.3c00644" @default.
- W4360816963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36961475" @default.
- W4360816963 hasPublicationYear "2023" @default.
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