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• W4360821502 abstract "Abstract TLR 7/8 agonists are highly potent immunostimulators, though their clinical translation has been met with mixed success, due to their high toxicity as a result of an unregulated systemic immune activation. There is enormous potential to augment cancer immunotherapies with synthetic TLR 7/8 agonists, though a thorough control of pharmacokinetics and localization is needed for the general use of TLR 7/8 agonists in cancer immunotherapy. Herein, we control localization of TLR 7/8 agonists, by exploiting the extensive tissue retention of poly(acrylic acid-co-styrene). In a murine CT26 model, we find that covalently attaching TLR 7/8 agonists to the copolymer allows for retaining the drug in the tumor microenvironment for at least 15 weeks, after intratumoral injection, and results in a curative monotherapy. The copolymer itself is a new avenue for attaining prolonged tissue rentention for covalently attached drugs." @default.
• W4360821502 created "2023-03-25" @default.
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• W4360821502 date "2023-03-24" @default.
• W4360821502 modified "2023-09-26" @default.
• W4360821502 title "Cancer Immunotherapy through Tissue Adhering Polymers" @default.
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• W4360821502 doi "https://doi.org/10.1101/2023.03.23.533909" @default.
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