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- W4360823632 abstract "Carbohydrates are an important class of naturally active products and play vital roles in regulating various physiological activities. To meet the demand for carbohydrate-based libraries used for the identification of potential drug candidates for pharmaceutical-related targets, we developed a set of on-DNA protocols to construct the DNA-encoded glycoconjugates, including Seyferth-Gilbert homologation, anomeric azidation, and CuAAC cyclization. These on-DNA chemistries enable the generation and modification of DNA-linked glycosyl compounds with good conversions and broad substrate scope. Finally, three DNA-linked glycoconjugate libraries were successfully generated to demonstrate their applicability and feasibility in library preparation." @default.
- W4360823632 created "2023-03-25" @default.
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- W4360823632 date "2023-03-24" @default.
- W4360823632 modified "2023-10-15" @default.
- W4360823632 title "Modular Click Assembly DNA-Encoded Glycoconjugate Libraries with on-DNA Functional Group Transformations" @default.
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- W4360823632 doi "https://doi.org/10.1021/acs.bioconjchem.3c00068" @default.
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