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• W4360827696 abstract "<ns4:p><ns4:bold>Background</ns4:bold><ns4:bold>:</ns4:bold> Plai or<ns4:italic> </ns4:italic><ns4:italic>Zingiber</ns4:italic><ns4:italic> </ns4:italic><ns4:italic>cassumunar</ns4:italic> Roxb. was registered into the Thai Traditional Medicine list since 2011. However, there is limited evidence regarding Plai as a treatment in painful diabetic neuropathy (PDN). Therefore, this study aimed to evaluate the efficacy of topical <ns4:italic>Zingiber</ns4:italic><ns4:italic> </ns4:italic><ns4:italic>cassumunar</ns4:italic>.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold><ns4:bold>:</ns4:bold> A RCT was conducted in patients with PDN during February to March 2019. All participants received oral gabapentin 300 mg before bed as a standard regimen. The intervention group (n=16) received Plai balm 15%w/w 0.5 gram to apply on their feet three times a day and the control group (n=15) received placebo balm to similarly apply. Pain score at baseline, 2<ns4:sup>nd</ns4:sup> and 4<ns4:sup>th</ns4:sup> weeks were assessed and compared. Patients’ quality of life, and adverse events, were collected. Mean pain scores before and after treatment in each group and between groups were also analyzed.</ns4:p><ns4:p> <ns4:bold>Results</ns4:bold><ns4:bold>:</ns4:bold> At the end of week two and week four, the Plai group showed statistically significant lesser mean pain scores than the placebo group by -1.47 (95%CI: -1.96 to -1.30, p-value < 0.001), and by -1.51 (95%CI: -1.92 to -0.13, p-value = 0.027), respectively. Moreover, the Plai group had more cases number/ percentages with at least 50% pain score reduction than the placebo group [12/16 (75%) vs 3/15 (20%), p-value = 0.004]. However, there was no statistically significant difference in quality of life between the two groups (overall p-value = 0.366). Adverse event was not found in any groups.</ns4:p><ns4:p> <ns4:bold>Conclusions</ns4:bold><ns4:bold>:</ns4:bold> <ns4:italic>Zingiber</ns4:italic><ns4:italic> </ns4:italic><ns4:italic>cassumunar</ns4:italic> balm (Plai) was efficacious for pain reduction in painful diabetic neuropathy.</ns4:p><ns4:p> <ns4:bold>Registration</ns4:bold><ns4:bold>:</ns4:bold> Registered with the Thai Clinical Trials Registry; TCTR20200221001.</ns4:p>" @default.
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• W4360827696 date "2023-03-24" @default.
• W4360827696 modified "2023-09-26" @default.
• W4360827696 title "Effect of topical Zingiber cassumunar on painful diabetic neuropathy: a double-blind randomized-controlled trial" @default.
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• W4360827696 doi "https://doi.org/10.12688/f1000research.131344.1" @default.
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