Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360837527> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4360837527 abstract "Abstract Cancer immunotherapy using checkpoint inhibitors is considered a promising approach in various cancers, however, around 55–87% of patients fail to respond to this treatment. Combinatorial therapy through targeted nano-size particles carrying various Toll-like receptor (TLR) agonists to the tumor site can enhance the therapeutic index by activation of intratumoral antigen-presenting cell (APC). Outer membrane vesicles (OMVs) secreted by all gram-negative bacteria present various surface-exposed immune stimulators in their native conformation and Toll-like receptor activating components. In this study, OMVs were engineered to target highly overexpressing EGFR cancer cells in vitro . Affinity-based assays with both EGFR positive and negative cells were performed, and the equilibrium dissociation constant (Kd) of the designed scFv was calculated. Then, we employed the syngeneic model of a triple-negative mouse breast cancer, 4T1, to assess the function of bioengineered OMVs in vivo . Bioengineered OMVs were able to attach to EGFR high-expression cells in vitro . Analyzing the effectiveness of these nanovesicles in a triple-negative breast tumor mice model indicated that the administration route plays an important role in stimulating anti-tumor response. Both intraperitoneal (i.p.) and intratumoral (i.t.) injections of bioengineered OMVs stimulated innate immune response by activating natural killer cells and decreasing the rate of M2 macrophage in the tumor microenvironment. Contrary to the i.p. route with significant tumor size reduction, the in i.t. route only the growth of the tumor was inhibited. Considering both in vitro and in vivo results obtained in this study indicates the potential of OMVs as an effective anti-tumor strategy in future studies." @default.
- W4360837527 created "2023-03-25" @default.
- W4360837527 creator A5000568569 @default.
- W4360837527 creator A5021375662 @default.
- W4360837527 creator A5082711098 @default.
- W4360837527 date "2023-03-22" @default.
- W4360837527 modified "2023-09-27" @default.
- W4360837527 title "Anti-EGFR Bioengineered Bacterial Outer Membrane Vesicles as Targeted Immunotherapy Agents in Triple-Negative Breast Tumor Murine Model" @default.
- W4360837527 cites W1992007086 @default.
- W4360837527 cites W2003690177 @default.
- W4360837527 cites W2023667658 @default.
- W4360837527 cites W2026073020 @default.
- W4360837527 cites W2089663915 @default.
- W4360837527 cites W2132053993 @default.
- W4360837527 cites W2133403756 @default.
- W4360837527 cites W2420202036 @default.
- W4360837527 cites W2755907882 @default.
- W4360837527 cites W2768420706 @default.
- W4360837527 cites W2801222998 @default.
- W4360837527 cites W2801573336 @default.
- W4360837527 cites W2938729099 @default.
- W4360837527 cites W2981784931 @default.
- W4360837527 cites W3006975085 @default.
- W4360837527 cites W3027262891 @default.
- W4360837527 cites W3030200736 @default.
- W4360837527 cites W3036292187 @default.
- W4360837527 cites W3037722178 @default.
- W4360837527 cites W3103758115 @default.
- W4360837527 cites W3108623682 @default.
- W4360837527 cites W3111580887 @default.
- W4360837527 cites W3199574355 @default.
- W4360837527 cites W4205315499 @default.
- W4360837527 cites W4212909415 @default.
- W4360837527 cites W4221123224 @default.
- W4360837527 cites W4283711968 @default.
- W4360837527 cites W4283800983 @default.
- W4360837527 cites W4300690180 @default.
- W4360837527 cites W4311121609 @default.
- W4360837527 cites W4313467517 @default.
- W4360837527 doi "https://doi.org/10.21203/rs.3.rs-2656358/v1" @default.
- W4360837527 hasPublicationYear "2023" @default.
- W4360837527 type Work @default.
- W4360837527 citedByCount "0" @default.
- W4360837527 crossrefType "posted-content" @default.
- W4360837527 hasAuthorship W4360837527A5000568569 @default.
- W4360837527 hasAuthorship W4360837527A5021375662 @default.
- W4360837527 hasAuthorship W4360837527A5082711098 @default.
- W4360837527 hasBestOaLocation W43608375271 @default.
- W4360837527 hasConcept C150903083 @default.
- W4360837527 hasConcept C185592680 @default.
- W4360837527 hasConcept C202751555 @default.
- W4360837527 hasConcept C203014093 @default.
- W4360837527 hasConcept C207001950 @default.
- W4360837527 hasConcept C26291073 @default.
- W4360837527 hasConcept C2776107976 @default.
- W4360837527 hasConcept C2777701055 @default.
- W4360837527 hasConcept C2780674031 @default.
- W4360837527 hasConcept C502942594 @default.
- W4360837527 hasConcept C55493867 @default.
- W4360837527 hasConcept C71924100 @default.
- W4360837527 hasConcept C86803240 @default.
- W4360837527 hasConcept C8891405 @default.
- W4360837527 hasConceptScore W4360837527C150903083 @default.
- W4360837527 hasConceptScore W4360837527C185592680 @default.
- W4360837527 hasConceptScore W4360837527C202751555 @default.
- W4360837527 hasConceptScore W4360837527C203014093 @default.
- W4360837527 hasConceptScore W4360837527C207001950 @default.
- W4360837527 hasConceptScore W4360837527C26291073 @default.
- W4360837527 hasConceptScore W4360837527C2776107976 @default.
- W4360837527 hasConceptScore W4360837527C2777701055 @default.
- W4360837527 hasConceptScore W4360837527C2780674031 @default.
- W4360837527 hasConceptScore W4360837527C502942594 @default.
- W4360837527 hasConceptScore W4360837527C55493867 @default.
- W4360837527 hasConceptScore W4360837527C71924100 @default.
- W4360837527 hasConceptScore W4360837527C86803240 @default.
- W4360837527 hasConceptScore W4360837527C8891405 @default.
- W4360837527 hasLocation W43608375271 @default.
- W4360837527 hasOpenAccess W4360837527 @default.
- W4360837527 hasPrimaryLocation W43608375271 @default.
- W4360837527 hasRelatedWork W2791825614 @default.
- W4360837527 hasRelatedWork W2804415345 @default.
- W4360837527 hasRelatedWork W3025154575 @default.
- W4360837527 hasRelatedWork W4281389645 @default.
- W4360837527 hasRelatedWork W4285024394 @default.
- W4360837527 hasRelatedWork W4285731353 @default.
- W4360837527 hasRelatedWork W4286629873 @default.
- W4360837527 hasRelatedWork W4304080672 @default.
- W4360837527 hasRelatedWork W4304979265 @default.
- W4360837527 hasRelatedWork W4319459629 @default.
- W4360837527 isParatext "false" @default.
- W4360837527 isRetracted "false" @default.
- W4360837527 workType "article" @default.