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• W4360839138 endingPage "101918" @default.
• W4360839138 startingPage "101918" @default.
• W4360839138 abstract "Alzheimer's disease (AD) is the most common form of dementia and numerous studies reported a higher prevalence and incidence of AD among women. Although women have longer lifetime, longevity does not wholly explain the higher frequency and lifetime risk in women. It is important to understand sex differences in AD pathophysiology and pathogenesis, which could provide foundation for future clinical AD research. Here, we reviewed the most recent and relevant literature on sex differences in biological change of AD from macroscopical neuroimaging to microscopical pathologic change (neuronal degeneration, synaptic dysfunction, amyloid-beta and tau accumulation). We also discussed sex differences in cellular mechanisms related to AD (neuroinflammation, mitochondria dysfunction, oxygen stress, apoptosis, autophagy, blood-brain-barrier dysfunction, gut microbiome alteration, bulk and single cell/nucleus omics) and possible causes underlying these differences including sex-chromosome, sex hormone and hypothalamic-pituitary- adrenal (HPA) axis effects." @default.
• W4360839138 created "2023-03-25" @default.
• W4360839138 creator A5029257310 @default.
• W4360839138 creator A5031129892 @default.
• W4360839138 creator A5046817100 @default.
• W4360839138 date "2023-06-01" @default.
• W4360839138 modified "2023-09-27" @default.
• W4360839138 title "Sex difference in biological change and mechanism of Alzheimer’s disease: From macro- to micro-landscape" @default.
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