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• W4360839275 endingPage "104890" @default.
• W4360839275 startingPage "104890" @default.
• W4360839275 abstract "This study employed systems biology and high-throughput technologies to analyze complex molecular components of MS pathophysiology, combining data from multiple omics sources to identify potential biomarkers and propose therapeutic targets and repurposed drugs for MS treatment. This study analyzed GEO microarray datasets and MS proteomics data using geWorkbench, CTD, and COREMINE to identify differentially expressed genes associated with MS disease. Protein-protein interaction networks were constructed using Cytoscape and its plugins, and functional enrichment analysis was performed to identify crucial molecules. A drug-gene interaction network was also created using DGIdb to propose medications. This study identified 592 differentially expressed genes (DEGs) associated with MS disease using GEO, proteomics, and text-mining datasets. 37 DEGs were found to be important by topographical network studies, and 6 were identified as the most significant for MS pathophysiology. Additionally, we proposed six drugs that target these key genes. Crucial molecules identified in this study were dysregulated in MS and likely play a key role in the disease mechanism, warranting further research. Additionally, we proposed repurposing certain FDA-approved drugs for MS treatment. Our in silico results were supported by previous experimental research on some of the target genes and drugs. As the long-lasting investigations continue to discover new pathological territories in neurodegeneration, here we apply a systems biology approach to determine multiple sclerosis's molecular and pathophysiological origin and identify multiple sclerosis crucial genes that contribute to candidating new biomarkers and proposing new medications." @default.
• W4360839275 created "2023-03-25" @default.
• W4360839275 creator A5038764001 @default.
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• W4360839275 date "2023-05-01" @default.
• W4360839275 modified "2023-10-13" @default.
• W4360839275 title "Deciphering crucial genes in multiple sclerosis pathogenesis and drug repurposing: A systems biology approach" @default.
• W4360839275 cites W1531010890 @default.
• W4360839275 cites W1670760818 @default.
• W4360839275 cites W1763258797 @default.
• W4360839275 cites W1797058518 @default.
• W4360839275 cites W1933464941 @default.
• W4360839275 cites W1946389953 @default.
• W4360839275 cites W1968559117 @default.
• W4360839275 cites W1969889522 @default.
• W4360839275 cites W1971421925 @default.
• W4360839275 cites W1978486653 @default.
• W4360839275 cites W1985213868 @default.
• W4360839275 cites W1987057401 @default.
• W4360839275 cites W1991189747 @default.
• W4360839275 cites W2001675597 @default.
• W4360839275 cites W2005789443 @default.
• W4360839275 cites W2007056541 @default.
• W4360839275 cites W2007313674 @default.
• W4360839275 cites W2018544869 @default.
• W4360839275 cites W2021521740 @default.
• W4360839275 cites W2024336151 @default.
• W4360839275 cites W2035098555 @default.
• W4360839275 cites W2037725018 @default.
• W4360839275 cites W2041765499 @default.
• W4360839275 cites W2050493600 @default.
• W4360839275 cites W2053425459 @default.
• W4360839275 cites W2053800415 @default.
• W4360839275 cites W2062533676 @default.
• W4360839275 cites W2063639010 @default.
• W4360839275 cites W2063664792 @default.
• W4360839275 cites W2066716464 @default.
• W4360839275 cites W2090739226 @default.
• W4360839275 cites W2092995520 @default.
• W4360839275 cites W2103758700 @default.
• W4360839275 cites W2105490558 @default.
• W4360839275 cites W2107235884 @default.
• W4360839275 cites W2110658722 @default.
• W4360839275 cites W2112704756 @default.
• W4360839275 cites W2117929821 @default.
• W4360839275 cites W2117944169 @default.
• W4360839275 cites W2124001239 @default.
• W4360839275 cites W2130790725 @default.
• W4360839275 cites W2134387783 @default.
• W4360839275 cites W2136850043 @default.
• W4360839275 cites W2139503567 @default.
• W4360839275 cites W2152135248 @default.
• W4360839275 cites W2153032620 @default.
• W4360839275 cites W2154346708 @default.
• W4360839275 cites W2159675211 @default.
• W4360839275 cites W2159941448 @default.
• W4360839275 cites W2180909681 @default.
• W4360839275 cites W2182218920 @default.
• W4360839275 cites W2325038063 @default.
• W4360839275 cites W2332199262 @default.
• W4360839275 cites W2332948907 @default.
• W4360839275 cites W2468762798 @default.
• W4360839275 cites W2581061082 @default.
• W4360839275 cites W2643595164 @default.
• W4360839275 cites W2645093983 @default.
• W4360839275 cites W2746589792 @default.
• W4360839275 cites W2785661286 @default.
• W4360839275 cites W2789373730 @default.
• W4360839275 cites W2790491367 @default.
• W4360839275 cites W2792909494 @default.
• W4360839275 cites W2800767933 @default.
• W4360839275 cites W2883072533 @default.
• W4360839275 cites W2889327166 @default.
• W4360839275 cites W2897998319 @default.
• W4360839275 cites W2942261628 @default.
• W4360839275 cites W2985117983 @default.
• W4360839275 cites W2996763848 @default.
• W4360839275 cites W3000180226 @default.
• W4360839275 cites W3004110863 @default.
• W4360839275 cites W3009541903 @default.
• W4360839275 cites W3045677734 @default.
• W4360839275 cites W3093001157 @default.
• W4360839275 cites W3116254457 @default.
• W4360839275 cites W3159500189 @default.
• W4360839275 cites W3174375819 @default.
• W4360839275 cites W3197692203 @default.
• W4360839275 cites W4255855797 @default.
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• W4360839275 doi "https://doi.org/10.1016/j.jprot.2023.104890" @default.
• W4360839275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36966969" @default.
• W4360839275 hasPublicationYear "2023" @default.
• W4360839275 type Work @default.

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