Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360839579> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4360839579 abstract "Abstract In chronic lymphocytic leukemia, measurable residual disease (MRD) depth following fixed-duration treatment is associated with progression-free survival. MRD is usually reported at the end of treatment as a static parameter, but successive MRD measurements allow more accurately characterization of MRD dynamics, which may reveal additional prognostic information. To study the value of MRD dynamics, we used the IGHV leader-based NGS assay to longitudinally measured MRD in 60 patients treated in the HOVON-139/GIVE trial, in which previously untreated patients received two cycles of pre-induction with obinutuzumab, followed by one year induction treatment with obinutuzumab and venetoclax, followed by randomization to consolidation treatment with venetoclax or MRD-conditional consolidation. Induction treatment resulted in undetectable MRD (uMRD) (<10-5) in 93% of assessed patients, with 85% and 74% of patients retaining uMRD at six and twelve months after randomization. High levels of early-stage MRD, assessed during venetoclax ramp up, were associated with failure of achieving uMRD after induction treatment, whereas low levels of early-stage MRD predicted a low probability of loss of uMRD and disease progression after randomization. Venetoclax consolidation treatment significantly impaired polyclonal IGHV repertoire reconstitution after induction treatment with venetoclax and obinituzumab. In conclusion, very early-stage MRD levels were associated with treatment outcomes." @default.
- W4360839579 created "2023-03-25" @default.
- W4360839579 creator A5001794970 @default.
- W4360839579 creator A5003539898 @default.
- W4360839579 creator A5004217461 @default.
- W4360839579 creator A5014965698 @default.
- W4360839579 creator A5022562787 @default.
- W4360839579 creator A5028084153 @default.
- W4360839579 creator A5047666215 @default.
- W4360839579 creator A5055564359 @default.
- W4360839579 creator A5058526578 @default.
- W4360839579 creator A5064164625 @default.
- W4360839579 creator A5064810101 @default.
- W4360839579 creator A5067879926 @default.
- W4360839579 creator A5076709979 @default.
- W4360839579 creator A5089930630 @default.
- W4360839579 date "2023-03-24" @default.
- W4360839579 modified "2023-09-28" @default.
- W4360839579 title "Early-stage measurable residual disease dynamics and IGHV repertoire reconstitution during venetoclax and obinutuzumab treatment in chronic lymphocytic leukemia" @default.
- W4360839579 cites W2901005342 @default.
- W4360839579 cites W2948436219 @default.
- W4360839579 cites W2955830819 @default.
- W4360839579 cites W2962038803 @default.
- W4360839579 cites W3211328341 @default.
- W4360839579 cites W4214696988 @default.
- W4360839579 cites W4281385697 @default.
- W4360839579 cites W4295038000 @default.
- W4360839579 cites W4310093704 @default.
- W4360839579 doi "https://doi.org/10.21203/rs.3.rs-2648000/v1" @default.
- W4360839579 hasPublicationYear "2023" @default.
- W4360839579 type Work @default.
- W4360839579 citedByCount "0" @default.
- W4360839579 crossrefType "posted-content" @default.
- W4360839579 hasAuthorship W4360839579A5001794970 @default.
- W4360839579 hasAuthorship W4360839579A5003539898 @default.
- W4360839579 hasAuthorship W4360839579A5004217461 @default.
- W4360839579 hasAuthorship W4360839579A5014965698 @default.
- W4360839579 hasAuthorship W4360839579A5022562787 @default.
- W4360839579 hasAuthorship W4360839579A5028084153 @default.
- W4360839579 hasAuthorship W4360839579A5047666215 @default.
- W4360839579 hasAuthorship W4360839579A5055564359 @default.
- W4360839579 hasAuthorship W4360839579A5058526578 @default.
- W4360839579 hasAuthorship W4360839579A5064164625 @default.
- W4360839579 hasAuthorship W4360839579A5064810101 @default.
- W4360839579 hasAuthorship W4360839579A5067879926 @default.
- W4360839579 hasAuthorship W4360839579A5076709979 @default.
- W4360839579 hasAuthorship W4360839579A5089930630 @default.
- W4360839579 hasBestOaLocation W43608395791 @default.
- W4360839579 hasConcept C126322002 @default.
- W4360839579 hasConcept C143998085 @default.
- W4360839579 hasConcept C146357865 @default.
- W4360839579 hasConcept C151730666 @default.
- W4360839579 hasConcept C203014093 @default.
- W4360839579 hasConcept C204243189 @default.
- W4360839579 hasConcept C2777607594 @default.
- W4360839579 hasConcept C2777609679 @default.
- W4360839579 hasConcept C2777938653 @default.
- W4360839579 hasConcept C2778461978 @default.
- W4360839579 hasConcept C2779675984 @default.
- W4360839579 hasConcept C2779823535 @default.
- W4360839579 hasConcept C535046627 @default.
- W4360839579 hasConcept C71924100 @default.
- W4360839579 hasConcept C86803240 @default.
- W4360839579 hasConceptScore W4360839579C126322002 @default.
- W4360839579 hasConceptScore W4360839579C143998085 @default.
- W4360839579 hasConceptScore W4360839579C146357865 @default.
- W4360839579 hasConceptScore W4360839579C151730666 @default.
- W4360839579 hasConceptScore W4360839579C203014093 @default.
- W4360839579 hasConceptScore W4360839579C204243189 @default.
- W4360839579 hasConceptScore W4360839579C2777607594 @default.
- W4360839579 hasConceptScore W4360839579C2777609679 @default.
- W4360839579 hasConceptScore W4360839579C2777938653 @default.
- W4360839579 hasConceptScore W4360839579C2778461978 @default.
- W4360839579 hasConceptScore W4360839579C2779675984 @default.
- W4360839579 hasConceptScore W4360839579C2779823535 @default.
- W4360839579 hasConceptScore W4360839579C535046627 @default.
- W4360839579 hasConceptScore W4360839579C71924100 @default.
- W4360839579 hasConceptScore W4360839579C86803240 @default.
- W4360839579 hasLocation W43608395791 @default.
- W4360839579 hasOpenAccess W4360839579 @default.
- W4360839579 hasPrimaryLocation W43608395791 @default.
- W4360839579 hasRelatedWork W2204827588 @default.
- W4360839579 hasRelatedWork W2754654824 @default.
- W4360839579 hasRelatedWork W2794302045 @default.
- W4360839579 hasRelatedWork W2894684271 @default.
- W4360839579 hasRelatedWork W2946200248 @default.
- W4360839579 hasRelatedWork W4295564767 @default.
- W4360839579 hasRelatedWork W4308968203 @default.
- W4360839579 hasRelatedWork W4360839579 @default.
- W4360839579 hasRelatedWork W4361812247 @default.
- W4360839579 hasRelatedWork W4382929662 @default.
- W4360839579 isParatext "false" @default.
- W4360839579 isRetracted "false" @default.
- W4360839579 workType "article" @default.