FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360840160> ?p ?o ?g. }

• W4360840160 endingPage "384" @default.
• W4360840160 startingPage "383c" @default.
• W4360840160 abstract "In Reply.—We read with interest the letter by Kenneth Frankel, MD, in reference to our paper “Solid thyroid follicular nodules with longitudinal nuclear grooves.”1 We thank Dr Frankel for his interest in our publication and for his very thoughtful and pertinent questions. He asks 3 specific questions that we would like to respond to separately.First, the author points out that the features illustrated in our paper include fine nuclear chromatin, nuclear folding, prominent micronucleoli, and oval shapes, which would qualify by cytology for a Bethesda category V diagnosis, and he asks whether we would recommend including this entity along with noninvasive follicular thyroid neoplasm with papillary features (NIFTP) in the Bethesda commentary for false-positive diagnosis of papillary carcinoma. The answer is yes, these cytologic features have the potential for confusion with papillary thyroid carcinoma (PTC) by cytology and should be considered as a potential cause of false-positive fine-needle aspiration (FNA) cytology. But this begs a more pragmatic question: How often should we expect to find these lesions in FNA cytology? As stated in our paper, most of the lesions were small and less than 1 cm in greatest diameter and were identified incidentally in specimens resected for other causes. Unlike in NIFTP, the likelihood that such lesions will become clinically apparent and specifically targeted for FNA is thus quite minimal.Dr Frankel also asks whether we would recommend treating these lesions differently from those with a diagnosis of micropapillary carcinoma. As stated in our paper, we believe these lesions should be treated conservatively because of their indolent behavior. Given that in most of our cases they were incidental findings in lobectomy or thyroidectomy specimens removed for other reasons, we favor a simple follow-up and clinical observation rather than offering additional treatment.Finally, the author asks whether “pragmatically, does the diagnosis of ‘follicular nodule with longitudinal nuclear grooves' make a difference in patient care?” We believe the answer is yes. Most of the cases in our study were referred in consultation for the suspicion of PTC and with the question of “rule out PTC.” We believe it would have been a disservice to these patients had they received a diagnosis of PTC given the indolent clinical behavior of these nodules and because of the potential implications for treatment. The point of the study was to alert pathologists to this unusual lesion that has the potential for being confused for PTC and to share our experience with long-term follow-up, which showed an indolent clinical behavior. We understand that similar lesions, like micropapillary thyroid carcinoma and even conventional PTC, can also frequently show an indolent clinical behavior; however, the label of “carcinoma” for such lesions always implies the possibility for additional treatment, not to mention the psychologic burden of a cancer diagnosis. For this reason, we feel it is appropriate to segregate this entity from PTC. One of the messages of the study, we believe, is “not everything with longitudinal nuclear grooves is necessarily PTC.”" @default.
• W4360840160 created "2023-03-25" @default.
• W4360840160 creator A5032579505 @default.
• W4360840160 creator A5077523407 @default.
• W4360840160 date "2023-03-23" @default.
• W4360840160 modified "2023-09-26" @default.
• W4360840160 title "In Reply" @default.
• W4360840160 cites W3209238871 @default.
• W4360840160 doi "https://doi.org/10.5858/arpa.2022-0434-le" @default.
• W4360840160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36961930" @default.
• W4360840160 hasPublicationYear "2023" @default.
• W4360840160 type Work @default.
• W4360840160 citedByCount "0" @default.
• W4360840160 crossrefType "journal-article" @default.
• W4360840160 hasAuthorship W4360840160A5032579505 @default.
• W4360840160 hasAuthorship W4360840160A5077523407 @default.
• W4360840160 hasBestOaLocation W43608401601 @default.
• W4360840160 hasConcept C11171543 @default.
• W4360840160 hasConcept C126322002 @default.
• W4360840160 hasConcept C126838900 @default.
• W4360840160 hasConcept C142724271 @default.
• W4360840160 hasConcept C15744967 @default.
• W4360840160 hasConcept C18823058 @default.
• W4360840160 hasConcept C2775934546 @default.
• W4360840160 hasConcept C2776170712 @default.
• W4360840160 hasConcept C2778654104 @default.
• W4360840160 hasConcept C2781140086 @default.
• W4360840160 hasConcept C2993294228 @default.
• W4360840160 hasConcept C2993477687 @default.
• W4360840160 hasConcept C526584372 @default.
• W4360840160 hasConcept C61434518 @default.
• W4360840160 hasConcept C71924100 @default.
• W4360840160 hasConceptScore W4360840160C11171543 @default.
• W4360840160 hasConceptScore W4360840160C126322002 @default.
• W4360840160 hasConceptScore W4360840160C126838900 @default.
• W4360840160 hasConceptScore W4360840160C142724271 @default.
• W4360840160 hasConceptScore W4360840160C15744967 @default.
• W4360840160 hasConceptScore W4360840160C18823058 @default.
• W4360840160 hasConceptScore W4360840160C2775934546 @default.
• W4360840160 hasConceptScore W4360840160C2776170712 @default.
• W4360840160 hasConceptScore W4360840160C2778654104 @default.
• W4360840160 hasConceptScore W4360840160C2781140086 @default.
• W4360840160 hasConceptScore W4360840160C2993294228 @default.
• W4360840160 hasConceptScore W4360840160C2993477687 @default.
• W4360840160 hasConceptScore W4360840160C526584372 @default.
• W4360840160 hasConceptScore W4360840160C61434518 @default.
• W4360840160 hasConceptScore W4360840160C71924100 @default.
• W4360840160 hasIssue "4" @default.
• W4360840160 hasLocation W43608401601 @default.
• W4360840160 hasLocation W43608401602 @default.
• W4360840160 hasOpenAccess W4360840160 @default.
• W4360840160 hasPrimaryLocation W43608401601 @default.
• W4360840160 hasRelatedWork W1971701506 @default.
• W4360840160 hasRelatedWork W2030901811 @default.
• W4360840160 hasRelatedWork W2036950817 @default.
• W4360840160 hasRelatedWork W2042089854 @default.
• W4360840160 hasRelatedWork W2053762012 @default.
• W4360840160 hasRelatedWork W2055919607 @default.
• W4360840160 hasRelatedWork W2084563561 @default.
• W4360840160 hasRelatedWork W2352738391 @default.
• W4360840160 hasRelatedWork W2398615191 @default.
• W4360840160 hasRelatedWork W2158682157 @default.
• W4360840160 hasVolume "147" @default.
• W4360840160 isParatext "false" @default.
• W4360840160 isRetracted "false" @default.
• W4360840160 workType "article" @default.