Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360848081> ?p ?o ?g. }
- W4360848081 endingPage "1957" @default.
- W4360848081 startingPage "1957" @default.
- W4360848081 abstract "Tumor progression and cancer metastasis has been linked to the release of microparticles (MPs), which are shed upon cell activation or apoptosis and display parental cell antigens, phospholipids such as phosphatidylserine (PS), and nucleic acids on their external surfaces. In this review, we highlight the biogenesis of MPs as well as the pathophysiological processes of PS externalization and its involvement in coagulation activation. We review the available evidence, suggesting that coagulation factors (mainly tissue factor, thrombin, and fibrin) assist in multiple steps of tumor dissemination, including epithelial-mesenchymal transition, extracellular matrix remodeling, immune escape, and tumor angiogenesis to support the formation of the pre-metastatic niche. Platelets are not just bystander cells in circulation but are functional players in primary tumor growth and metastasis. Tumor-induced platelet aggregation protects circulating tumor cells (CTCs) from the blood flow shear forces and immune cell attack while also promoting the binding of CTCs to endothelial cells and extravasation, which activates tumor invasion and sustains metastasis. Finally, in terms of therapy, lactadherin can inhibit coagulation by competing effectively with coagulation factors for PS binding sites and may similarly delay tumor progression. Furthermore, we also investigate the therapeutic potential of coagulation factor inhibitors within the context of cancer treatment. The development of multiple therapies targeting platelet activation and platelet-tumor cell interactions may not only reduce the lethal consequences of thrombosis but also impede tumor growth and spread." @default.
- W4360848081 created "2023-03-25" @default.
- W4360848081 creator A5003479391 @default.
- W4360848081 creator A5027257617 @default.
- W4360848081 creator A5049276811 @default.
- W4360848081 creator A5058259187 @default.
- W4360848081 creator A5070397040 @default.
- W4360848081 creator A5077506566 @default.
- W4360848081 date "2023-03-24" @default.
- W4360848081 modified "2023-10-18" @default.
- W4360848081 title "Microparticle Phosphatidylserine Mediates Coagulation: Involvement in Tumor Progression and Metastasis" @default.
- W4360848081 cites W100656547 @default.
- W4360848081 cites W1482962573 @default.
- W4360848081 cites W1509894190 @default.
- W4360848081 cites W1572562929 @default.
- W4360848081 cites W1578834667 @default.
- W4360848081 cites W1598061310 @default.
- W4360848081 cites W1689351220 @default.
- W4360848081 cites W1727122499 @default.
- W4360848081 cites W1778960512 @default.
- W4360848081 cites W1816831867 @default.
- W4360848081 cites W1828447324 @default.
- W4360848081 cites W1960637288 @default.
- W4360848081 cites W1963904011 @default.
- W4360848081 cites W1965469314 @default.
- W4360848081 cites W1966556597 @default.
- W4360848081 cites W1968662389 @default.
- W4360848081 cites W1969002010 @default.
- W4360848081 cites W1974255833 @default.
- W4360848081 cites W1974382524 @default.
- W4360848081 cites W1974585921 @default.
- W4360848081 cites W1980493113 @default.
- W4360848081 cites W1982546060 @default.
- W4360848081 cites W1987168967 @default.
- W4360848081 cites W1988177647 @default.
- W4360848081 cites W1989632399 @default.
- W4360848081 cites W1990939074 @default.
- W4360848081 cites W1995827114 @default.
- W4360848081 cites W1996765015 @default.
- W4360848081 cites W1999082557 @default.
- W4360848081 cites W2000499186 @default.
- W4360848081 cites W2003909308 @default.
- W4360848081 cites W2009649000 @default.
- W4360848081 cites W2011816149 @default.
- W4360848081 cites W2011823999 @default.
- W4360848081 cites W2012535096 @default.
- W4360848081 cites W2016741520 @default.
- W4360848081 cites W2018038784 @default.
- W4360848081 cites W2020291681 @default.
- W4360848081 cites W2020413792 @default.
- W4360848081 cites W2020654599 @default.
- W4360848081 cites W2021337455 @default.
- W4360848081 cites W2022035044 @default.
- W4360848081 cites W2022616393 @default.
- W4360848081 cites W2023163047 @default.
- W4360848081 cites W2025474825 @default.
- W4360848081 cites W2026680863 @default.
- W4360848081 cites W2032651612 @default.
- W4360848081 cites W2040593473 @default.
- W4360848081 cites W2044748328 @default.
- W4360848081 cites W2045247817 @default.
- W4360848081 cites W2046783628 @default.
- W4360848081 cites W2047534454 @default.
- W4360848081 cites W2048606972 @default.
- W4360848081 cites W2048898883 @default.
- W4360848081 cites W2049184800 @default.
- W4360848081 cites W2053244650 @default.
- W4360848081 cites W2055315529 @default.
- W4360848081 cites W2055792439 @default.
- W4360848081 cites W2058468432 @default.
- W4360848081 cites W2059416893 @default.
- W4360848081 cites W2062245523 @default.
- W4360848081 cites W2063264068 @default.
- W4360848081 cites W2065663086 @default.
- W4360848081 cites W2066007175 @default.
- W4360848081 cites W2066671159 @default.
- W4360848081 cites W2067011387 @default.
- W4360848081 cites W2068773189 @default.
- W4360848081 cites W2071523386 @default.
- W4360848081 cites W2075245112 @default.
- W4360848081 cites W2075542566 @default.
- W4360848081 cites W2076936113 @default.
- W4360848081 cites W2078558642 @default.
- W4360848081 cites W2083325724 @default.
- W4360848081 cites W2087993142 @default.
- W4360848081 cites W2093170847 @default.
- W4360848081 cites W2095576178 @default.
- W4360848081 cites W2095843897 @default.
- W4360848081 cites W2100445694 @default.
- W4360848081 cites W2102324547 @default.
- W4360848081 cites W2105622812 @default.
- W4360848081 cites W2106505027 @default.
- W4360848081 cites W2111775556 @default.
- W4360848081 cites W2114120215 @default.
- W4360848081 cites W2117188579 @default.
- W4360848081 cites W2117692326 @default.
- W4360848081 cites W2117776343 @default.
- W4360848081 cites W2120239669 @default.