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- W4360858864 endingPage "6140" @default.
- W4360858864 startingPage "6140" @default.
- W4360858864 abstract "Tightly controlled inflammation is an indispensable mechanism in the maintenance of cellular and organismal homeostasis in living organisms. However, aberrant inflammation is detrimental and has been suggested as a key contributor to organ injury with different etiologies. Substance P (SP) is a neuropeptide with a robust effect on inflammation. The proinflammatory effects of SP are achieved by activating its functional receptors, namely the neurokinin 1 receptor (NK1R) receptor and mas-related G protein-coupled receptors X member 2 (MRGPRX2) and its murine homolog MRGPRB2. Upon activation, the receptors further signal to several cellular signaling pathways involved in the onset, development, and progression of inflammation. Therefore, excessive SP–NK1R or SP–MRGPRX2/B2 signals have been implicated in the pathogenesis of inflammation-associated organ injury. In this review, we summarize our current knowledge of SP and its receptors and the emerging roles of the SP–NK1R system and the SP–MRGPRX2/B2 system in inflammation and injury in multiple organs resulting from different pathologies. We also briefly discuss the prospect of developing a therapeutic strategy for inflammatory organ injury by disrupting the proinflammatory actions of SP via pharmacological intervention." @default.
- W4360858864 created "2023-03-25" @default.
- W4360858864 creator A5004446271 @default.
- W4360858864 creator A5063525443 @default.
- W4360858864 date "2023-03-24" @default.
- W4360858864 modified "2023-09-29" @default.
- W4360858864 title "Inflammation and Organ Injury the Role of Substance P and Its Receptors" @default.
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