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- W4360861757 endingPage "6106" @default.
- W4360861757 startingPage "6106" @default.
- W4360861757 abstract "Human diseases are characterized by the perpetuation of an inflammatory condition in which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS production leads to DNA damage, protein carbonylation and lipid peroxidation, conditions that lead to a worsening of inflammatory disorders. In particular, compromised mitochondria sustain a stressful condition in the cell, such that mitochondrial dysfunctions become pathogenic, causing human disorders related to inflammatory reactions. Indeed, the triggered inflammation loses its beneficial properties and turns harmful if dysregulation and dysfunctions are not addressed. Thus, reducing oxidative stress with ROS scavenger compounds has proven to be a successful approach to reducing inflammation. Among these, natural compounds, in particular, polyphenols, alkaloids and coenzyme Q10, thanks to their antioxidant properties, are capable of inhibiting the activation of NF-κB and the expression of target genes, including those involved in inflammation. Even more, clinical trials, and in vivo and in vitro studies have demonstrated the antioxidant and anti-inflammatory effects of phytosomes, which are capable of increasing the bioavailability and effectiveness of natural compounds, and have long been considered an effective non-pharmacological therapy. Therefore, in this review, we wanted to highlight the relationship between inflammation, altered mitochondrial oxidative activity in pathological conditions, and the beneficial effects of phytosomes. To this end, a PubMed literature search was conducted with a focus on various in vitro and in vivo studies and clinical trials from 2014 to 2022." @default.
- W4360861757 created "2023-03-25" @default.
- W4360861757 creator A5077577527 @default.
- W4360861757 creator A5089004786 @default.
- W4360861757 creator A5091038674 @default.
- W4360861757 date "2023-03-24" @default.
- W4360861757 modified "2023-10-04" @default.
- W4360861757 title "Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust" @default.
- W4360861757 cites W1484882395 @default.
- W4360861757 cites W1540878808 @default.
- W4360861757 cites W1633660980 @default.
- W4360861757 cites W184874886 @default.
- W4360861757 cites W1914622032 @default.
- W4360861757 cites W1964126982 @default.
- W4360861757 cites W1991047945 @default.
- W4360861757 cites W1996789266 @default.
- W4360861757 cites W2004536682 @default.
- W4360861757 cites W2014877928 @default.
- W4360861757 cites W2017032119 @default.
- W4360861757 cites W2023453911 @default.
- W4360861757 cites W2034831207 @default.
- W4360861757 cites W2035232303 @default.
- W4360861757 cites W2036606290 @default.
- W4360861757 cites W2037303970 @default.
- W4360861757 cites W2042183116 @default.
- W4360861757 cites W2042232868 @default.
- W4360861757 cites W2042433863 @default.
- W4360861757 cites W2050271125 @default.
- W4360861757 cites W2050315287 @default.
- W4360861757 cites W2060004514 @default.
- W4360861757 cites W2068359668 @default.
- W4360861757 cites W2069375519 @default.
- W4360861757 cites W2075529886 @default.
- W4360861757 cites W2076598575 @default.
- W4360861757 cites W2079167667 @default.
- W4360861757 cites W2090734611 @default.
- W4360861757 cites W2093839463 @default.
- W4360861757 cites W2103010344 @default.
- W4360861757 cites W2118742454 @default.
- W4360861757 cites W2120049814 @default.
- W4360861757 cites W2120521980 @default.
- W4360861757 cites W2125699069 @default.
- W4360861757 cites W2143516276 @default.
- W4360861757 cites W2151391072 @default.
- W4360861757 cites W2159913536 @default.
- W4360861757 cites W2279003225 @default.
- W4360861757 cites W2425487349 @default.
- W4360861757 cites W2466124354 @default.
- W4360861757 cites W2474949213 @default.
- W4360861757 cites W2489667194 @default.
- W4360861757 cites W2504001075 @default.
- W4360861757 cites W2510134963 @default.
- W4360861757 cites W2544056465 @default.
- W4360861757 cites W2565383127 @default.
- W4360861757 cites W2580416727 @default.
- W4360861757 cites W2592838167 @default.
- W4360861757 cites W2597555000 @default.
- W4360861757 cites W2608180866 @default.
- W4360861757 cites W2613424718 @default.
- W4360861757 cites W2620769476 @default.
- W4360861757 cites W2788480107 @default.
- W4360861757 cites W2790189657 @default.
- W4360861757 cites W2792528268 @default.
- W4360861757 cites W2792738411 @default.
- W4360861757 cites W2795578307 @default.
- W4360861757 cites W2810279664 @default.
- W4360861757 cites W2884383626 @default.
- W4360861757 cites W2887287828 @default.
- W4360861757 cites W2890198942 @default.
- W4360861757 cites W2914746958 @default.
- W4360861757 cites W2918019780 @default.
- W4360861757 cites W2921875691 @default.
- W4360861757 cites W2950076870 @default.
- W4360861757 cites W2954782052 @default.
- W4360861757 cites W2969770706 @default.
- W4360861757 cites W2981063024 @default.
- W4360861757 cites W2984160887 @default.
- W4360861757 cites W2990475594 @default.
- W4360861757 cites W2996537134 @default.
- W4360861757 cites W2998980500 @default.
- W4360861757 cites W3000149875 @default.
- W4360861757 cites W3010809227 @default.
- W4360861757 cites W3011876055 @default.
- W4360861757 cites W3012405893 @default.
- W4360861757 cites W3015783759 @default.
- W4360861757 cites W3016264273 @default.
- W4360861757 cites W3027530623 @default.
- W4360861757 cites W3036453504 @default.
- W4360861757 cites W3037543582 @default.
- W4360861757 cites W3044538925 @default.
- W4360861757 cites W3091043182 @default.
- W4360861757 cites W3111127888 @default.
- W4360861757 cites W3121734311 @default.
- W4360861757 cites W3128128702 @default.
- W4360861757 cites W3130968559 @default.
- W4360861757 cites W3131448121 @default.
- W4360861757 cites W3134999759 @default.
- W4360861757 cites W3138261840 @default.