FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360873957> ?p ?o ?g. }

• W4360873957 endingPage "109448" @default.
• W4360873957 startingPage "109448" @default.
• W4360873957 abstract "Uveal melanoma (UM), the most frequent primary intraocular tumor in adults, has poor prognosis. High C-C motif chemokine ligand 18 (CCL18) has been detected in various tumors and is closely correlated with patients' clinicopathological characteristics. However, the essential role of CCL18 in UM remains unclear. Therefore, this study aimed to explore the prognostic value of CCL18 in UM. Uveal melanoma cells (M17) were transfected with pcDNA3.1-CCL18 si-RNA using Lipofectamine™ 2000. Cell growth and invasion abilities were measured through Cell Counting Kit-8 assay and invasion assay. RNA expression data and clinical and histopathological details were downloaded from the UM in The Cancer Genome Atlas (TCGA-UM) and GSE22138 datasets, which were defined as the training and validation cohorts, respectively. Univariate and multivariate Cox regression analyses were performed to identify significant prognostic biomarkers. The coefficients of these significant biomarkers generated by multivariate Cox proportional hazard regression analysis were used to establish a risk score formula. Functional enrichment analyses were also carried out. We found that downregulated CCL18 inhibits M17 cell growth and invasion in vitro. CCL18 may affect UM progression by altering C-C motif receptor 8 related pathways. Higher CCL18 expression was associated with worse clinical outcomes and tumor-specific death in the TCGA-UM dataset. Based on the coefficients obtained from the Cox proportional hazard regression analysis, a CCL18-related prognostic signature formula was constructed as follows: risk score = 0.05590 × age +2.43437 × chromosome 3 status +0.39496 × ExpressionCCL18. Notably, in this formula, the normal chromosome 3 was coded as 0, whereas the chromosome 3 loss was coded as 1. Each patient was assigned to either low-risk or high-risk groups using the median cut-off in the training cohort. High-risk patients survived for a shorter time than low-risk patients. The time-dependent and multivariate receiver operating characteristic curves showed promising diagnostic efficacy. Multivariate Cox regression analysis demonstrated the potential of this CCL18-related signature as an independent prognostic indicator. These results were validated using the GSE22138 dataset. In addition, in both TCGA-UM and GSE22138 datasets, stratification of clinical correlations and survival analyses based on this signature indicated the involvement of clinical progression and survival outcome in UM. In the high-risk group, Gene Ontology analyses mainly indicated the enrichment of immune response pathways, such as the T cell activation, response to interferon-gamma, antigen processing and presentation, interferon-gamma-mediated signaling pathway, MHC protein complex, MHC class II protein complex, antigen binding, and cytokine binding. Meanwhile, Kyoto Encyclopedia of Genes and Genomes analyses showed enrichments of pathways in cancer, cell adhesion, cytokine-cytokine receptor interaction, chemokine signaling pathway, Th1 and Th2 cell differentiation, and chemokine signaling pathway. Moreover, single-sample gene set enrichment analysis demonstrated the enrichment of almost all immune cells and immune functions in the high-risk group. In summary, a new prognostic CCL18-related signature was successfully established using the TCGA-UM dataset and validated using the GSE22138 dataset with meaningful predictive and diagnostic efficacies. This signature could serve as an independent and promising prognostic biomarker for patients with UM." @default.
• W4360873957 created "2023-03-25" @default.
• W4360873957 creator A5003167778 @default.
• W4360873957 creator A5007424613 @default.
• W4360873957 creator A5008771275 @default.
• W4360873957 creator A5029864208 @default.
• W4360873957 creator A5037149702 @default.
• W4360873957 creator A5037614287 @default.
• W4360873957 creator A5067715662 @default.
• W4360873957 creator A5070695035 @default.
• W4360873957 creator A5083095344 @default.
• W4360873957 date "2023-05-01" @default.
• W4360873957 modified "2023-10-02" @default.
• W4360873957 title "Identification and validation of a CCL18-related signature for prediction of overall survival in patients with uveal melanoma" @default.
• W4360873957 cites W1827304769 @default.
• W4360873957 cites W1934879924 @default.
• W4360873957 cites W1988258153 @default.
• W4360873957 cites W1995483790 @default.
• W4360873957 cites W1999380172 @default.
• W4360873957 cites W2026285612 @default.
• W4360873957 cites W2046229170 @default.
• W4360873957 cites W2046283885 @default.
• W4360873957 cites W2065310196 @default.
• W4360873957 cites W2072753925 @default.
• W4360873957 cites W2090859076 @default.
• W4360873957 cites W2093394403 @default.
• W4360873957 cites W2122367845 @default.
• W4360873957 cites W2130410032 @default.
• W4360873957 cites W2132309227 @default.
• W4360873957 cites W2138143763 @default.
• W4360873957 cites W2140685642 @default.
• W4360873957 cites W2143878396 @default.
• W4360873957 cites W2166771927 @default.
• W4360873957 cites W2408787182 @default.
• W4360873957 cites W2589936752 @default.
• W4360873957 cites W2745658163 @default.
• W4360873957 cites W2763653706 @default.
• W4360873957 cites W2803060899 @default.
• W4360873957 cites W2891337769 @default.
• W4360873957 cites W2892030326 @default.
• W4360873957 cites W2892745211 @default.
• W4360873957 cites W2901253659 @default.
• W4360873957 cites W2913801723 @default.
• W4360873957 cites W2915750835 @default.
• W4360873957 cites W2942576941 @default.
• W4360873957 cites W2944663789 @default.
• W4360873957 cites W2993358235 @default.
• W4360873957 cites W2997221881 @default.
• W4360873957 cites W3002671583 @default.
• W4360873957 cites W3012575010 @default.
• W4360873957 cites W3087151726 @default.
• W4360873957 cites W3095009692 @default.
• W4360873957 cites W3116809329 @default.
• W4360873957 cites W3148132672 @default.
• W4360873957 cites W3176872991 @default.
• W4360873957 cites W4200171484 @default.
• W4360873957 cites W4206314700 @default.
• W4360873957 cites W4224097084 @default.
• W4360873957 cites W4309700628 @default.
• W4360873957 cites W4313331406 @default.
• W4360873957 doi "https://doi.org/10.1016/j.exer.2023.109448" @default.
• W4360873957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36967081" @default.
• W4360873957 hasPublicationYear "2023" @default.
• W4360873957 type Work @default.
• W4360873957 citedByCount "1" @default.
• W4360873957 countsByYear W43608739572023 @default.
• W4360873957 crossrefType "journal-article" @default.
• W4360873957 hasAuthorship W4360873957A5003167778 @default.
• W4360873957 hasAuthorship W4360873957A5007424613 @default.
• W4360873957 hasAuthorship W4360873957A5008771275 @default.
• W4360873957 hasAuthorship W4360873957A5029864208 @default.
• W4360873957 hasAuthorship W4360873957A5037149702 @default.
• W4360873957 hasAuthorship W4360873957A5037614287 @default.
• W4360873957 hasAuthorship W4360873957A5067715662 @default.
• W4360873957 hasAuthorship W4360873957A5070695035 @default.
• W4360873957 hasAuthorship W4360873957A5083095344 @default.
• W4360873957 hasConcept C10515644 @default.
• W4360873957 hasConcept C126322002 @default.
• W4360873957 hasConcept C13373296 @default.
• W4360873957 hasConcept C143998085 @default.
• W4360873957 hasConcept C157081693 @default.
• W4360873957 hasConcept C170493617 @default.
• W4360873957 hasConcept C2777658100 @default.
• W4360873957 hasConcept C502942594 @default.
• W4360873957 hasConcept C50382708 @default.
• W4360873957 hasConcept C71924100 @default.
• W4360873957 hasConcept C86803240 @default.
• W4360873957 hasConceptScore W4360873957C10515644 @default.
• W4360873957 hasConceptScore W4360873957C126322002 @default.
• W4360873957 hasConceptScore W4360873957C13373296 @default.
• W4360873957 hasConceptScore W4360873957C143998085 @default.
• W4360873957 hasConceptScore W4360873957C157081693 @default.
• W4360873957 hasConceptScore W4360873957C170493617 @default.
• W4360873957 hasConceptScore W4360873957C2777658100 @default.
• W4360873957 hasConceptScore W4360873957C502942594 @default.
• W4360873957 hasConceptScore W4360873957C50382708 @default.
• W4360873957 hasConceptScore W4360873957C71924100 @default.
• W4360873957 hasConceptScore W4360873957C86803240 @default.

• next