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- W4360938240 abstract "Abstract Bacterial chromosomes are dynamically and spatially organised within cells. In slow-growing Escherichia coli , the chromosomal terminus is initially located at the new pole and must therefore migrate to midcell during replication to reproduce the same pattern in the daughter cells. Here, we use high-throughput time-lapse microscopy to quantify this transition, its timing and its relationship to chromosome segregation. We find that terminus centralisation is a rapid discrete event that occurs ~25 min after initial separation of duplicated origins and ~50 min before the onset of bulk nucleoid segregation but with substantial variation between cells. Despite this variation, its movement is tightly coincident with the completion of origin segregation, even in the absence of its linkage to the divisome, suggesting a coupling between these two events. Indeed, we find that terminus centralisation does not occur if origin segregation away from mid-cell is disrupted, which results in daughter cells having an inverted chromosome organisation. Overall, our study quantifies the choreography of origin-terminus positioning and identifies an unexplored connection between these loci, furthering our understanding of chromosome segregation in this bacterium." @default.
- W4360938240 created "2023-03-26" @default.
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- W4360938240 date "2023-03-25" @default.
- W4360938240 modified "2023-10-16" @default.
- W4360938240 title "Mid-cell migration of the chromosomal terminus is coupled to origin segregation in<i>Escherichia coli</i>" @default.
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- W4360938240 doi "https://doi.org/10.1101/2023.03.24.534095" @default.
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