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- W4360951881 abstract "Abstract Increasing evidence points to post-translational modifications (PTMs) as key regulators of alpha-synuclein (α-Syn) function in health and disease. However, whether these PTMs occur before or after α-Syn pathology formation and their role in regulating α-Syn toxicity remain unclear. In this study, we demonstrate that post-fibrillization nitration of α-Syn fibrils induced their fragmentation, modified their surface and dynamic properties but not their structure, and nearly abolished their seeding activity in primary neurons and in vivo . Furthermore, we show that the dynamic and surface properties of the fibrils, rather than simply their length, are important determinants of α-Syn fibril seeding activity. Altogether, our work demonstrates that post-aggregation modifications of α-Syn may provide novel approaches to target a central process that contributes to pathology formation and disease progression. Finally, our results suggest that the pattern of PTMs on pathological aggregates, rather than simply their presence, could be a key determinant of their toxicity and neurodegeneration. This calls for reconsidering current approaches relying solely on quantifying and correlating the level of pathology to assess the efficacy of novel therapies, as not all α-Syn aggregates in the brain are pathogenic." @default.
- W4360951881 created "2023-03-26" @default.
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- W4360951881 date "2023-03-25" @default.
- W4360951881 modified "2023-10-01" @default.
- W4360951881 title "Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and<i>in vivo</i>" @default.
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- W4360951881 cites W1630502818 @default.
- W4360951881 cites W1965095016 @default.
- W4360951881 cites W1969366577 @default.
- W4360951881 cites W1970650018 @default.
- W4360951881 cites W1973817566 @default.
- W4360951881 cites W1976841598 @default.
- W4360951881 cites W1979987809 @default.
- W4360951881 cites W1980947632 @default.
- W4360951881 cites W1989913002 @default.
- W4360951881 cites W1997818885 @default.
- W4360951881 cites W2005212584 @default.
- W4360951881 cites W2010395737 @default.
- W4360951881 cites W2025145394 @default.
- W4360951881 cites W2030499668 @default.
- W4360951881 cites W2047206971 @default.
- W4360951881 cites W2048897966 @default.
- W4360951881 cites W2055175471 @default.
- W4360951881 cites W2058441068 @default.
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- W4360951881 cites W2065949544 @default.
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- W4360951881 cites W2073235926 @default.
- W4360951881 cites W2075793841 @default.
- W4360951881 cites W2078591248 @default.
- W4360951881 cites W2079003999 @default.
- W4360951881 cites W2081879241 @default.
- W4360951881 cites W2089522371 @default.
- W4360951881 cites W2096061603 @default.
- W4360951881 cites W2107434243 @default.
- W4360951881 cites W2108865709 @default.
- W4360951881 cites W2125447215 @default.
- W4360951881 cites W2136332525 @default.
- W4360951881 cites W2150916538 @default.
- W4360951881 cites W2158089391 @default.
- W4360951881 cites W2161429104 @default.
- W4360951881 cites W2169821755 @default.
- W4360951881 cites W2317462515 @default.
- W4360951881 cites W2470103967 @default.
- W4360951881 cites W2567332350 @default.
- W4360951881 cites W2793431243 @default.
- W4360951881 cites W2806197261 @default.
- W4360951881 cites W2884263697 @default.
- W4360951881 cites W2885863704 @default.
- W4360951881 cites W2889082939 @default.
- W4360951881 cites W2890944761 @default.
- W4360951881 cites W2906543169 @default.
- W4360951881 cites W2943550823 @default.
- W4360951881 cites W2948686984 @default.
- W4360951881 cites W2951348834 @default.
- W4360951881 cites W2969023902 @default.
- W4360951881 cites W2993466834 @default.
- W4360951881 cites W2999229807 @default.
- W4360951881 cites W3000343326 @default.
- W4360951881 cites W3008786370 @default.
- W4360951881 cites W3030540323 @default.
- W4360951881 cites W3118586567 @default.
- W4360951881 cites W3157101799 @default.
- W4360951881 cites W3169544636 @default.
- W4360951881 cites W3180499864 @default.
- W4360951881 cites W4205912752 @default.
- W4360951881 cites W4210505632 @default.
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- W4360951881 doi "https://doi.org/10.1101/2023.03.24.534149" @default.
- W4360951881 hasPublicationYear "2023" @default.
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