FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360951937> ?p ?o ?g. }

• W4360951937 abstract "Abstract Aims To investigate the clinical status of insulin resistance (IR) and its correlation with disease duration in patients with type 1 diabetes (T1D). Materials and Methods Cross‐sectional data from a T1D cohort were obtained ( n = 923). IR‐related metabolic disorders including hypertension, obesity, and dyslipidemia were used as outcome variables to explore the cut‐off point for estimated glucose disposal rate (eGDR) by restricted cubic spline (RCS) curve. Regression models were used for multivariate analysis of the clinical factors associated with IR. The correlation between the status of IR and diabetes duration was depicted with the RCS curve. Results IR‐related metabolic disorders were observed in 39.4% of patients, with 9.1% meeting the criteria for metabolic syndrome. Specifically, patients with ≥10 years of T1D were more likely to have IR‐related metabolic disorders (54.7% vs. 36.9%, p < 0.05). The presence of IR, defined as an eGDR ≤9.0 mg/kg/min, was observed in 42.2% of patients. Patients with IR had a longer diabetes duration (3.5 vs. 2.7, years, p = 0.003) and higher insulin dose (0.5 vs. 0.4, units per kg per day, p < 0.001). Moreover, the presence of IR showed a gradual increase during 10 years' disease duration and further analysis showed that diabetes duration ≥10 years was a key element behind the development of IR and IR‐related metabolic disorders. Conclusions The status of IR is common in T1D patients, especially in those with ≥10 years of disease duration. Therapies targeting balancing glycaemic control and IR are needed to decrease the future risk of cardiovascular diseases in T1D. Clinical trial registration: ClinicalTrials.gov NCT03610984 (cohort study of patients with type 1 diabetes)." @default.
• W4360951937 created "2023-03-26" @default.
• W4360951937 creator A5003829618 @default.
• W4360951937 creator A5023521579 @default.
• W4360951937 creator A5031268488 @default.
• W4360951937 creator A5044655400 @default.
• W4360951937 creator A5049407947 @default.
• W4360951937 creator A5051677016 @default.
• W4360951937 creator A5057106452 @default.
• W4360951937 date "2023-04-08" @default.
• W4360951937 modified "2023-10-17" @default.
• W4360951937 title "Insulin resistance is more frequent in type 1 diabetes patients with long disease duration" @default.
• W4360951937 cites W1807663421 @default.
• W4360951937 cites W1965748339 @default.
• W4360951937 cites W1986349550 @default.
• W4360951937 cites W2050874020 @default.
• W4360951937 cites W2073526927 @default.
• W4360951937 cites W2079297835 @default.
• W4360951937 cites W2134273157 @default.
• W4360951937 cites W2141231160 @default.
• W4360951937 cites W2141428319 @default.
• W4360951937 cites W2143570364 @default.
• W4360951937 cites W2170838054 @default.
• W4360951937 cites W2326347426 @default.
• W4360951937 cites W2563994170 @default.
• W4360951937 cites W2751431861 @default.
• W4360951937 cites W2754299300 @default.
• W4360951937 cites W2782494600 @default.
• W4360951937 cites W2791533133 @default.
• W4360951937 cites W2883178692 @default.
• W4360951937 cites W2888536641 @default.
• W4360951937 cites W2946415573 @default.
• W4360951937 cites W3083547644 @default.
• W4360951937 cites W3157719027 @default.
• W4360951937 cites W3190250104 @default.
• W4360951937 cites W4206920508 @default.
• W4360951937 cites W4252910375 @default.
• W4360951937 cites W4281657724 @default.
• W4360951937 cites W4281789948 @default.
• W4360951937 doi "https://doi.org/10.1002/dmrr.3640" @default.
• W4360951937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36964977" @default.
• W4360951937 hasPublicationYear "2023" @default.
• W4360951937 type Work @default.
• W4360951937 citedByCount "0" @default.
• W4360951937 crossrefType "journal-article" @default.
• W4360951937 hasAuthorship W4360951937A5003829618 @default.
• W4360951937 hasAuthorship W4360951937A5023521579 @default.
• W4360951937 hasAuthorship W4360951937A5031268488 @default.
• W4360951937 hasAuthorship W4360951937A5044655400 @default.
• W4360951937 hasAuthorship W4360951937A5049407947 @default.
• W4360951937 hasAuthorship W4360951937A5051677016 @default.
• W4360951937 hasAuthorship W4360951937A5057106452 @default.
• W4360951937 hasConcept C126322002 @default.
• W4360951937 hasConcept C134018914 @default.
• W4360951937 hasConcept C2777180221 @default.
• W4360951937 hasConcept C2777391703 @default.
• W4360951937 hasConcept C2778096610 @default.
• W4360951937 hasConcept C2780578515 @default.
• W4360951937 hasConcept C2781232474 @default.
• W4360951937 hasConcept C511355011 @default.
• W4360951937 hasConcept C555293320 @default.
• W4360951937 hasConcept C71924100 @default.
• W4360951937 hasConcept C72563966 @default.
• W4360951937 hasConcept C90924648 @default.
• W4360951937 hasConceptScore W4360951937C126322002 @default.
• W4360951937 hasConceptScore W4360951937C134018914 @default.
• W4360951937 hasConceptScore W4360951937C2777180221 @default.
• W4360951937 hasConceptScore W4360951937C2777391703 @default.
• W4360951937 hasConceptScore W4360951937C2778096610 @default.
• W4360951937 hasConceptScore W4360951937C2780578515 @default.
• W4360951937 hasConceptScore W4360951937C2781232474 @default.
• W4360951937 hasConceptScore W4360951937C511355011 @default.
• W4360951937 hasConceptScore W4360951937C555293320 @default.
• W4360951937 hasConceptScore W4360951937C71924100 @default.
• W4360951937 hasConceptScore W4360951937C72563966 @default.
• W4360951937 hasConceptScore W4360951937C90924648 @default.
• W4360951937 hasFunder F4320321001 @default.
• W4360951937 hasIssue "6" @default.
• W4360951937 hasLocation W43609519371 @default.
• W4360951937 hasLocation W43609519372 @default.
• W4360951937 hasOpenAccess W4360951937 @default.
• W4360951937 hasPrimaryLocation W43609519371 @default.
• W4360951937 hasRelatedWork W1538061282 @default.
• W4360951937 hasRelatedWork W1999791383 @default.
• W4360951937 hasRelatedWork W2007805455 @default.
• W4360951937 hasRelatedWork W2028667143 @default.
• W4360951937 hasRelatedWork W2313454058 @default.
• W4360951937 hasRelatedWork W2385511906 @default.
• W4360951937 hasRelatedWork W2475280487 @default.
• W4360951937 hasRelatedWork W2590119640 @default.
• W4360951937 hasRelatedWork W2593732884 @default.
• W4360951937 hasRelatedWork W3122878625 @default.
• W4360951937 hasVolume "39" @default.
• W4360951937 isParatext "false" @default.
• W4360951937 isRetracted "false" @default.
• W4360951937 workType "article" @default.