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- W4360952106 abstract "Abstract Introducing a tri-coordinate boron-based functional group (e.g., boronic ester) into an unactivated C–H bond in the absence of directing groups is an ongoing challenge in synthetic chemistry. Despite previous developments in transition metal-catalyzed and -free approaches, C–H borylation of sterically hindered arenes remains a largely unsolved problem to date. Here, we report a synthetic strategy of a two-step, precious metal-free electrophilic C–H borylation of sterically hindered alkyl- and haloarenes to generate aryl boronic esters. The first step relies on electrophilic aromatic substitution (EAS) induced by cage-opening of Cs 2 [ closo -B 10 H 10 ], forming a 6-Ar- nido -B 10 H 13 product containing a B–C bond, followed by a cage deconstruction of arylated decaboranes promoted by diols. The combination of these two steps allows for the preparation of aryl boronic esters that are hardly accessible by current direct C–H borylation approaches. This reaction does not require any precious metals, highly-engineered ligands, pre-functionalized boron reagents, or inert conditions. In addition, the unique properties of a non-classical boron cluster electrophile intermediate, B 10 H 13 + , afford a regioselectivity with unique steric and electronic control without the undesirable side reactions." @default.
- W4360952106 created "2023-03-26" @default.
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- W4360952106 date "2023-03-25" @default.
- W4360952106 modified "2023-09-30" @default.
- W4360952106 title "Arene C–H borylation strategy enabled by a non-classical boron cluster-based electrophile" @default.
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- W4360952106 doi "https://doi.org/10.1038/s41467-023-37258-6" @default.
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