FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360952449> ?p ?o ?g. }

• W4360952449 endingPage "1076" @default.
• W4360952449 startingPage "1065" @default.
• W4360952449 abstract "In recent years, the development of bispecific antibodies (bsAbs) has become a major trend in the biopharmaceutical industry. By simultaneously engaging two molecular targets, bsAbs have exhibited unique mechanisms of action that could lead to clinical benefits unattainable by conventional monoclonal antibodies. The type of structure used to construct a bsAb directly influences the distance, angle, degree of freedom, and affinity between the two antibody binding sites and the interaction between the two antigens or the cells where the antigens are located, which have been bound by the antibody. Consequently, the structure of the bsAb is one of the most vital factors affecting its function. Herein, we reported for the first time a novel basic module bsAb format, VFV (Variable domain-Fab-Variable domain). And then, the feasibility of the VFV format was demonstrated by constructing a series of engager-like basic module bsAbs. Next, a series of VFV bsAbs containing Fc (VFV-Ig), Fab (VFV-Fab), or Hinge (VFV-Hinge) were developed based on Hxb module, and all of them had adequate purity and activity. Finally, a T cell engager bsAb with the potential to overcome on-target off-tumor activity was constructed according to the structural characteristics of VFV, which validated that the VFV module can be used as a new brick for the construction of various bsAbs. In a word, the successful construction of this bsAb format for the first time not only enriches the arsenal of the bsAb format, but also provides inspiration for the construction of new bsAbs. Nevertheless, we are fully aware that as a proof-of-concept study, this paper has many shortcomings, and there is still a lot of work to be done to determine whether VFV can serve as a platform for drug development." @default.
• W4360952449 created "2023-03-26" @default.
• W4360952449 creator A5025619660 @default.
• W4360952449 creator A5036215036 @default.
• W4360952449 creator A5046078938 @default.
• W4360952449 creator A5050106441 @default.
• W4360952449 creator A5057979727 @default.
• W4360952449 creator A5069358975 @default.
• W4360952449 creator A5069585400 @default.
• W4360952449 date "2023-03-25" @default.
• W4360952449 modified "2023-10-18" @default.
• W4360952449 title "A novel brick for bispecific antibody construction" @default.
• W4360952449 cites W1510837654 @default.
• W4360952449 cites W156336040 @default.
• W4360952449 cites W1564498610 @default.
• W4360952449 cites W1932781508 @default.
• W4360952449 cites W1968924601 @default.
• W4360952449 cites W1972193434 @default.
• W4360952449 cites W1981730803 @default.
• W4360952449 cites W1982878288 @default.
• W4360952449 cites W1987201232 @default.
• W4360952449 cites W1991644988 @default.
• W4360952449 cites W1992423971 @default.
• W4360952449 cites W1992928385 @default.
• W4360952449 cites W1995374080 @default.
• W4360952449 cites W1996768467 @default.
• W4360952449 cites W2011766387 @default.
• W4360952449 cites W2025779348 @default.
• W4360952449 cites W2051944033 @default.
• W4360952449 cites W2053872195 @default.
• W4360952449 cites W2056362227 @default.
• W4360952449 cites W2060209794 @default.
• W4360952449 cites W2068660599 @default.
• W4360952449 cites W2086146164 @default.
• W4360952449 cites W2086766201 @default.
• W4360952449 cites W2090193152 @default.
• W4360952449 cites W2111742915 @default.
• W4360952449 cites W2111823261 @default.
• W4360952449 cites W2158140628 @default.
• W4360952449 cites W2163065611 @default.
• W4360952449 cites W2168356942 @default.
• W4360952449 cites W2169656611 @default.
• W4360952449 cites W2316155442 @default.
• W4360952449 cites W2403476749 @default.
• W4360952449 cites W2425420867 @default.
• W4360952449 cites W2546299440 @default.
• W4360952449 cites W2560105450 @default.
• W4360952449 cites W2610978375 @default.
• W4360952449 cites W2735646340 @default.
• W4360952449 cites W2886423041 @default.
• W4360952449 cites W2890891923 @default.
• W4360952449 cites W2896093944 @default.
• W4360952449 cites W2897958605 @default.
• W4360952449 cites W2898833818 @default.
• W4360952449 cites W2931445906 @default.
• W4360952449 cites W3024123159 @default.
• W4360952449 cites W3158486916 @default.
• W4360952449 cites W3191219220 @default.
• W4360952449 cites W3200574709 @default.
• W4360952449 cites W4205628911 @default.
• W4360952449 doi "https://doi.org/10.1002/prot.26492" @default.
• W4360952449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36964928" @default.
• W4360952449 hasPublicationYear "2023" @default.
• W4360952449 type Work @default.
• W4360952449 citedByCount "0" @default.
• W4360952449 crossrefType "journal-article" @default.
• W4360952449 hasAuthorship W4360952449A5025619660 @default.
• W4360952449 hasAuthorship W4360952449A5036215036 @default.
• W4360952449 hasAuthorship W4360952449A5046078938 @default.
• W4360952449 hasAuthorship W4360952449A5050106441 @default.
• W4360952449 hasAuthorship W4360952449A5057979727 @default.
• W4360952449 hasAuthorship W4360952449A5069358975 @default.
• W4360952449 hasAuthorship W4360952449A5069585400 @default.
• W4360952449 hasConcept C147483822 @default.
• W4360952449 hasConcept C159654299 @default.
• W4360952449 hasConcept C203014093 @default.
• W4360952449 hasConcept C3020495827 @default.
• W4360952449 hasConcept C41008148 @default.
• W4360952449 hasConcept C542903549 @default.
• W4360952449 hasConcept C86803240 @default.
• W4360952449 hasConceptScore W4360952449C147483822 @default.
• W4360952449 hasConceptScore W4360952449C159654299 @default.
• W4360952449 hasConceptScore W4360952449C203014093 @default.
• W4360952449 hasConceptScore W4360952449C3020495827 @default.
• W4360952449 hasConceptScore W4360952449C41008148 @default.
• W4360952449 hasConceptScore W4360952449C542903549 @default.
• W4360952449 hasConceptScore W4360952449C86803240 @default.
• W4360952449 hasIssue "8" @default.
• W4360952449 hasLocation W43609524491 @default.
• W4360952449 hasLocation W43609524492 @default.
• W4360952449 hasOpenAccess W4360952449 @default.
• W4360952449 hasPrimaryLocation W43609524491 @default.
• W4360952449 hasRelatedWork W1604248381 @default.
• W4360952449 hasRelatedWork W1943797027 @default.
• W4360952449 hasRelatedWork W1997716688 @default.
• W4360952449 hasRelatedWork W1998831848 @default.
• W4360952449 hasRelatedWork W2029145496 @default.
• W4360952449 hasRelatedWork W2038126255 @default.

• next