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• W4360954914 endingPage "127670" @default.
• W4360954914 startingPage "127670" @default.
• W4360954914 abstract "In this work, thermo-responsive nanocomposites based on hafnium-dope magnetite (Hf0.6Fe2.4O4) nanoparticles and poly(vinylcaprolactam) (PNVCL) were prepared for the targeted delivery of doxorubicin (DOX). First, the hafnium-doped magnetite nanoparticles were synthesized by the inverse chemical co-precipitation method and then functionalized with vinyltrimethoxysilane (VTMS) to endow with vinyl groups which are susceptible to free radical polymerization. Then the “grafting from” approach was used to graft PNVCL onto VTMS-functionalized Hf0.6Fe2.4O4. These nanocomposites were characterized by X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). DOX molecules were loaded onto the nanocomposites and the DOX release studies were carried out at different temperature (25 and 37 °C) in phosphate buffer solution 5.8. The XRD and XPS results demonstrated the incorporation of hafnium into the structure of magnetite. TEM images showed semi-spherical Hf0.6Fe2.4O4 nanoparticles surrounded by a layer of PNVCL while the XPS studies demonstrated the covalent interaction between the nanoparticles and the polymer. Finally, the PNVCL-modified Hf0.6Fe2.4O4 nanoparticles showed a sustained release of this drug during the first 24 h at 37 °C reaching up to 70% of cumulative drug release which make them suitable as drug delivery systems." @default.
• W4360954914 created "2023-03-26" @default.
• W4360954914 creator A5027085766 @default.
• W4360954914 creator A5041187807 @default.
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• W4360954914 creator A5065595262 @default.
• W4360954914 creator A5075509993 @default.
• W4360954914 creator A5079293127 @default.
• W4360954914 date "2023-06-01" @default.
• W4360954914 modified "2023-10-16" @default.
• W4360954914 title "Hafnium-doped nano-magnetite/poly(N-vinylcaprolactam) composites for doxorubicin release" @default.
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• W4360954914 doi "https://doi.org/10.1016/j.matchemphys.2023.127670" @default.
• W4360954914 hasPublicationYear "2023" @default.
• W4360954914 type Work @default.

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