Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360955507> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4360955507 endingPage "100128" @default.
- W4360955507 startingPage "100128" @default.
- W4360955507 abstract "Anti-platelet factor 4 (PF4) antibodies in vaccine-induced immune thrombotic thrombocytopenia (VITT) appear to be transient, with discrepant persistence depending on the platform used for detection.We aimed to report a longitudinal study of antibody persistence using 2 ELISA platforms and 2 platelet-activating functional assays in a clinical cohort of patients with VITT referred for follow-up testing.In total, 32 Australian patients with VITT or pre-VITT, confirmed by expert adjudication, with samples referred for clinical follow-up were included. Clinical follow-up assays, including Stago and Hyphen ELISAs, procoagulant platelet flow cytometry, and modified PF4-serotonin-release assay, were performed according to the pattern of reactivity for that patient at diagnosis.The median follow-up was 24 weeks after diagnosis. A general decline in anti-PF4 antibody levels and platelet-activating capacity over time was observed with a more rapid median time to resolution of 16 weeks by functional assay vs 24 weeks by Stago ELISA. Decline in platelet-activating antibody levels detected by functional assays mirrored Stago ELISA titer but not Hyphen. However, 87% of patients received a documented second vaccination and 74% received an mRNA booster with no reported adverse events.Anti-PF4 antibodies persist longer than functional platelet-activating antibodies in VITT but do not warrant avoidance of subsequent vaccinations. Persistence detection is assay-dependent. Stago ELISA may be a surrogate where functional assays are unavailable for follow-up testing of confirmed patients with VITT." @default.
- W4360955507 created "2023-03-26" @default.
- W4360955507 creator A5014332529 @default.
- W4360955507 creator A5028312991 @default.
- W4360955507 creator A5030789412 @default.
- W4360955507 creator A5042597609 @default.
- W4360955507 creator A5062343356 @default.
- W4360955507 creator A5075581552 @default.
- W4360955507 creator A5080222867 @default.
- W4360955507 creator A5089722288 @default.
- W4360955507 creator A5090245300 @default.
- W4360955507 date "2023-03-01" @default.
- W4360955507 modified "2023-10-16" @default.
- W4360955507 title "Platelet-activating functional assay resolution in vaccine-induced immune thrombotic thrombocytopenia: differential alignment to PF4 ELISA platforms" @default.
- W4360955507 cites W2316071283 @default.
- W4360955507 cites W3161515984 @default.
- W4360955507 cites W3169733086 @default.
- W4360955507 cites W3175653029 @default.
- W4360955507 cites W4200140699 @default.
- W4360955507 cites W4205856417 @default.
- W4360955507 cites W4206903368 @default.
- W4360955507 cites W4210482245 @default.
- W4360955507 cites W4210828588 @default.
- W4360955507 cites W4212786169 @default.
- W4360955507 cites W4220830703 @default.
- W4360955507 cites W4224493721 @default.
- W4360955507 cites W4226145370 @default.
- W4360955507 cites W4226156644 @default.
- W4360955507 cites W4229000850 @default.
- W4360955507 cites W4280567542 @default.
- W4360955507 cites W4281703522 @default.
- W4360955507 cites W4289528558 @default.
- W4360955507 cites W4295897904 @default.
- W4360955507 doi "https://doi.org/10.1016/j.rpth.2023.100128" @default.
- W4360955507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37122532" @default.
- W4360955507 hasPublicationYear "2023" @default.
- W4360955507 type Work @default.
- W4360955507 citedByCount "0" @default.
- W4360955507 crossrefType "journal-article" @default.
- W4360955507 hasAuthorship W4360955507A5014332529 @default.
- W4360955507 hasAuthorship W4360955507A5028312991 @default.
- W4360955507 hasAuthorship W4360955507A5030789412 @default.
- W4360955507 hasAuthorship W4360955507A5042597609 @default.
- W4360955507 hasAuthorship W4360955507A5062343356 @default.
- W4360955507 hasAuthorship W4360955507A5075581552 @default.
- W4360955507 hasAuthorship W4360955507A5080222867 @default.
- W4360955507 hasAuthorship W4360955507A5089722288 @default.
- W4360955507 hasAuthorship W4360955507A5090245300 @default.
- W4360955507 hasBestOaLocation W43609555071 @default.
- W4360955507 hasConcept C159654299 @default.
- W4360955507 hasConcept C159973064 @default.
- W4360955507 hasConcept C203014093 @default.
- W4360955507 hasConcept C22070199 @default.
- W4360955507 hasConcept C2776472838 @default.
- W4360955507 hasConcept C3018697912 @default.
- W4360955507 hasConcept C71924100 @default.
- W4360955507 hasConcept C8891405 @default.
- W4360955507 hasConcept C89560881 @default.
- W4360955507 hasConceptScore W4360955507C159654299 @default.
- W4360955507 hasConceptScore W4360955507C159973064 @default.
- W4360955507 hasConceptScore W4360955507C203014093 @default.
- W4360955507 hasConceptScore W4360955507C22070199 @default.
- W4360955507 hasConceptScore W4360955507C2776472838 @default.
- W4360955507 hasConceptScore W4360955507C3018697912 @default.
- W4360955507 hasConceptScore W4360955507C71924100 @default.
- W4360955507 hasConceptScore W4360955507C8891405 @default.
- W4360955507 hasConceptScore W4360955507C89560881 @default.
- W4360955507 hasFunder F4320315996 @default.
- W4360955507 hasFunder F4320325396 @default.
- W4360955507 hasIssue "3" @default.
- W4360955507 hasLocation W43609555071 @default.
- W4360955507 hasLocation W43609555072 @default.
- W4360955507 hasLocation W43609555073 @default.
- W4360955507 hasOpenAccess W4360955507 @default.
- W4360955507 hasPrimaryLocation W43609555071 @default.
- W4360955507 hasRelatedWork W2011284024 @default.
- W4360955507 hasRelatedWork W2023718145 @default.
- W4360955507 hasRelatedWork W2079614982 @default.
- W4360955507 hasRelatedWork W2135344285 @default.
- W4360955507 hasRelatedWork W2169204359 @default.
- W4360955507 hasRelatedWork W2203797292 @default.
- W4360955507 hasRelatedWork W2590416412 @default.
- W4360955507 hasRelatedWork W3018291191 @default.
- W4360955507 hasRelatedWork W4242038659 @default.
- W4360955507 hasRelatedWork W4327932567 @default.
- W4360955507 hasVolume "7" @default.
- W4360955507 isParatext "false" @default.
- W4360955507 isRetracted "false" @default.
- W4360955507 workType "article" @default.