FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360962029> ?p ?o ?g. }

• W4360962029 abstract "Abstract Background When a fetus was found has cleft lip palate (CL/P) by prenatal anatomical ultrasound assessment, it is difficult to determine the CL/P is isolated or companied with other animalities such as intellectual disability. We preformed comprehensive genetic test to support prenatal genetic counselling for CL/P fetus which is detected by ultrasound screening. Results 105 unrelated fetuses with CL/P were enrolled. After excluding aneuploidy cases, SNP array and clinical exome sequencing (CES) were preformed simultaneously. All the fetuses were followed-up. Fetuses with CL/P were divided into two groups, cleft lip (CL)and cleft palate with or without cleft lip (CP/CLP). The detection rate was 12.4% (13/105) of the cases, in which SNP array contributed 3.8% (4/105) while CES added 8.6% yields. The positive rate of the CL group was lower than that of the CP/CLP group (0% (0/23) versus 15.9% (13/82), P = 0.067). CP/CLP with additional anomalies has higher positive rate than that of the apparently isolated CP/CLP (53.3% (8/15) versus 7.5% (5/67), P < 0.001). Furthermore, midline or bilateral CP/CLP had different yields in subgroups of CP/CLP. The rate of termination of pregnancy in positive group is much higher than that of the negative group (84.6% (11/13) versus 36.9% (31/84)). Conclusions Prenatal diagnosis with SNP array companied with CES was helpful for etiology analysis of fetuses with CL/P. Genetic etiology analysis was more valuable for CP/CLP than for CL. Moreover, SNP array companied with CES could change the clinical outcome for prenatal CL/P fetuses and reduce the residual risk for negative cases." @default.
• W4360962029 created "2023-03-26" @default.
• W4360962029 creator A5000510528 @default.
• W4360962029 creator A5004690387 @default.
• W4360962029 creator A5005242574 @default.
• W4360962029 creator A5013060966 @default.
• W4360962029 creator A5039254465 @default.
• W4360962029 creator A5045416081 @default.
• W4360962029 creator A5056397635 @default.
• W4360962029 creator A5059668825 @default.
• W4360962029 creator A5062029154 @default.
• W4360962029 creator A5067614932 @default.
• W4360962029 creator A5073156180 @default.
• W4360962029 creator A5073435344 @default.
• W4360962029 creator A5077875782 @default.
• W4360962029 creator A5084888732 @default.
• W4360962029 creator A5086664284 @default.
• W4360962029 date "2023-03-24" @default.
• W4360962029 modified "2023-10-15" @default.
• W4360962029 title "Prenatal diagnosis of cleft lip and palate: a study of clinical utility" @default.
• W4360962029 cites W1993734867 @default.
• W4360962029 cites W2010888896 @default.
• W4360962029 cites W2051978340 @default.
• W4360962029 cites W2151672916 @default.
• W4360962029 cites W2277991109 @default.
• W4360962029 cites W2405823546 @default.
• W4360962029 cites W2560641002 @default.
• W4360962029 cites W2608936951 @default.
• W4360962029 cites W2740099763 @default.
• W4360962029 cites W2793871792 @default.
• W4360962029 cites W2794433138 @default.
• W4360962029 cites W2910583407 @default.
• W4360962029 cites W2912938672 @default.
• W4360962029 cites W2973151973 @default.
• W4360962029 cites W2983742483 @default.
• W4360962029 cites W2995937822 @default.
• W4360962029 cites W3000483992 @default.
• W4360962029 cites W3023646448 @default.
• W4360962029 cites W4297850469 @default.
• W4360962029 doi "https://doi.org/10.21203/rs.3.rs-2703454/v1" @default.
• W4360962029 hasPublicationYear "2023" @default.
• W4360962029 type Work @default.
• W4360962029 citedByCount "0" @default.
• W4360962029 crossrefType "posted-content" @default.
• W4360962029 hasAuthorship W4360962029A5000510528 @default.
• W4360962029 hasAuthorship W4360962029A5004690387 @default.
• W4360962029 hasAuthorship W4360962029A5005242574 @default.
• W4360962029 hasAuthorship W4360962029A5013060966 @default.
• W4360962029 hasAuthorship W4360962029A5039254465 @default.
• W4360962029 hasAuthorship W4360962029A5045416081 @default.
• W4360962029 hasAuthorship W4360962029A5056397635 @default.
• W4360962029 hasAuthorship W4360962029A5059668825 @default.
• W4360962029 hasAuthorship W4360962029A5062029154 @default.
• W4360962029 hasAuthorship W4360962029A5067614932 @default.
• W4360962029 hasAuthorship W4360962029A5073156180 @default.
• W4360962029 hasAuthorship W4360962029A5073435344 @default.
• W4360962029 hasAuthorship W4360962029A5077875782 @default.
• W4360962029 hasAuthorship W4360962029A5084888732 @default.
• W4360962029 hasAuthorship W4360962029A5086664284 @default.
• W4360962029 hasBestOaLocation W43609620291 @default.
• W4360962029 hasConcept C104317684 @default.
• W4360962029 hasConcept C126322002 @default.
• W4360962029 hasConcept C131872663 @default.
• W4360962029 hasConcept C135763542 @default.
• W4360962029 hasConcept C137627325 @default.
• W4360962029 hasConcept C139275648 @default.
• W4360962029 hasConcept C153209595 @default.
• W4360962029 hasConcept C16671776 @default.
• W4360962029 hasConcept C172680121 @default.
• W4360962029 hasConcept C2778258057 @default.
• W4360962029 hasConcept C2779234561 @default.
• W4360962029 hasConcept C2779672484 @default.
• W4360962029 hasConcept C29456083 @default.
• W4360962029 hasConcept C2992422692 @default.
• W4360962029 hasConcept C30481170 @default.
• W4360962029 hasConcept C501734568 @default.
• W4360962029 hasConcept C54355233 @default.
• W4360962029 hasConcept C71924100 @default.
• W4360962029 hasConcept C86803240 @default.
• W4360962029 hasConceptScore W4360962029C104317684 @default.
• W4360962029 hasConceptScore W4360962029C126322002 @default.
• W4360962029 hasConceptScore W4360962029C131872663 @default.
• W4360962029 hasConceptScore W4360962029C135763542 @default.
• W4360962029 hasConceptScore W4360962029C137627325 @default.
• W4360962029 hasConceptScore W4360962029C139275648 @default.
• W4360962029 hasConceptScore W4360962029C153209595 @default.
• W4360962029 hasConceptScore W4360962029C16671776 @default.
• W4360962029 hasConceptScore W4360962029C172680121 @default.
• W4360962029 hasConceptScore W4360962029C2778258057 @default.
• W4360962029 hasConceptScore W4360962029C2779234561 @default.
• W4360962029 hasConceptScore W4360962029C2779672484 @default.
• W4360962029 hasConceptScore W4360962029C29456083 @default.
• W4360962029 hasConceptScore W4360962029C2992422692 @default.
• W4360962029 hasConceptScore W4360962029C30481170 @default.
• W4360962029 hasConceptScore W4360962029C501734568 @default.
• W4360962029 hasConceptScore W4360962029C54355233 @default.
• W4360962029 hasConceptScore W4360962029C71924100 @default.
• W4360962029 hasConceptScore W4360962029C86803240 @default.
• W4360962029 hasLocation W43609620291 @default.
• W4360962029 hasOpenAccess W4360962029 @default.

• next