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• W4360971552 abstract "Cancer is the one of the most prevalent causes of the deaths globally and also a major hindrance to achieve the desired life expectancy in most of the countries. Across a wide range of neoplastic disorders, oncobiosis biotransformation, an alteration in microbiome compartment is observed. Several changes occur in microbiome compartment during ovarian and cervical cancer. Oncobiosis is seen in several compartments including cervicovaginal, ovarian and intra-tumoral compartment, serum and intestines, upper and lower genital tract. The gut microbiome can be modulated by use of pro-, pre-, and synbiotics that can also modulate the host metabolism. This in turn has a huge potential to minimize the side effects and even enhances the cancer management health benefits. Hence, the World Health Organization (WHO) and the Food and Agriculture Organization (FAO) define probiotics as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.” Symbiotics are defined as “combination[s] of probiotic bacteria and growth promoting prebiotic ingredient[s]” that achieve “synergism.” Synbiotics may act as antimutagens, giving their carcinogen scavenging and elimination action. Major challenge in use of synbiotics for cervical and ovarian cancer is that these synbiotics may also imbalance the microbiota as risk of infection is very high in immunocompromised cancer patients and lack of scientific evidence. Very less evidence is reported for cervical and ovarian cancer. There is a need of clinical trials to be initiated for establishing the clinical benefits of synbiotics in cervical and ovarian cancer. Regulatory authorities should initiate the studies to build in the evidence so that the health benefits associated with these synbiotics can enhance the quality of life in cancer patients." @default.
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• W4360971552 date "2023-01-01" @default.
• W4360971552 modified "2023-09-24" @default.
• W4360971552 title "Uncharted Potentials of Synbiotics in Treatment of Cervical and Ovarian Cancer" @default.
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• W4360971552 doi "https://doi.org/10.1007/978-981-19-7550-9_11" @default.
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