Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360971738> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4360971738 endingPage "175628642311618" @default.
- W4360971738 startingPage "175628642311618" @default.
- W4360971738 abstract "Ofatumumab (OFA), a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B-cells. The purpose of this study was to report the therapeutic effect and safety of OFA in two refractory anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis cases which were nonresponsive to first-line immunotherapies. Two severely affected anti-NMDAR encephalitis patients (mRS score: 5) with resistance to standard immunotherapies (corticosteroids, IV immunoglobulins) were treated with OFA (3 subcutaneous injections of 20 mg on days 1, 7, 14). The patients’ guardians declined plasma exchange (PE) and RTX. The clinical outcome of the patients was followed up for 6 months after the administration of OFA. Treatment with OFA led to rapid clinical improvement accompanied by the enhancement of neuropsychiatric function, disappearance of brain MRI lesions, and decline in partial NMDAR antibody titer. The CD20-positive B-cells were completely depleted in both patients. Moreover, the therapy was well tolerated with no adverse effects. The patients were discharged without clinical deficits and with significantly improved cognition. OFA appeared to be highly effective in the two presented cases despite the limited first-line therapy without PE, which suggests good potential for the application of OFA in this field. However, the lingering effects of previously administered corticosteroids and IV immunoglobulins cannot be excluded." @default.
- W4360971738 created "2023-03-30" @default.
- W4360971738 creator A5004349051 @default.
- W4360971738 creator A5027448540 @default.
- W4360971738 creator A5058217577 @default.
- W4360971738 date "2023-01-01" @default.
- W4360971738 modified "2023-09-26" @default.
- W4360971738 title "A novel use and dramatic efficacy of ofatumumab for the treatment of anti-N-methyl-D-aspartate receptor encephalitis: a report of two cases" @default.
- W4360971738 cites W2016226293 @default.
- W4360971738 cites W2070457428 @default.
- W4360971738 cites W2082107657 @default.
- W4360971738 cites W2146199022 @default.
- W4360971738 cites W2163022996 @default.
- W4360971738 cites W2802139618 @default.
- W4360971738 cites W2908911620 @default.
- W4360971738 cites W2913312009 @default.
- W4360971738 cites W2951902689 @default.
- W4360971738 cites W3007658184 @default.
- W4360971738 cites W3047302551 @default.
- W4360971738 cites W3091749321 @default.
- W4360971738 cites W3131463167 @default.
- W4360971738 cites W3201389259 @default.
- W4360971738 cites W3204317850 @default.
- W4360971738 cites W4200565245 @default.
- W4360971738 doi "https://doi.org/10.1177/17562864231161890" @default.
- W4360971738 hasPublicationYear "2023" @default.
- W4360971738 type Work @default.
- W4360971738 citedByCount "0" @default.
- W4360971738 crossrefType "journal-article" @default.
- W4360971738 hasAuthorship W4360971738A5004349051 @default.
- W4360971738 hasAuthorship W4360971738A5027448540 @default.
- W4360971738 hasAuthorship W4360971738A5058217577 @default.
- W4360971738 hasBestOaLocation W43609717381 @default.
- W4360971738 hasConcept C121608353 @default.
- W4360971738 hasConcept C126322002 @default.
- W4360971738 hasConcept C159654299 @default.
- W4360971738 hasConcept C170493617 @default.
- W4360971738 hasConcept C18031839 @default.
- W4360971738 hasConcept C197934379 @default.
- W4360971738 hasConcept C203014093 @default.
- W4360971738 hasConcept C2522874641 @default.
- W4360971738 hasConcept C2777701055 @default.
- W4360971738 hasConcept C2778714382 @default.
- W4360971738 hasConcept C67018056 @default.
- W4360971738 hasConcept C71924100 @default.
- W4360971738 hasConcept C83455156 @default.
- W4360971738 hasConcept C90924648 @default.
- W4360971738 hasConceptScore W4360971738C121608353 @default.
- W4360971738 hasConceptScore W4360971738C126322002 @default.
- W4360971738 hasConceptScore W4360971738C159654299 @default.
- W4360971738 hasConceptScore W4360971738C170493617 @default.
- W4360971738 hasConceptScore W4360971738C18031839 @default.
- W4360971738 hasConceptScore W4360971738C197934379 @default.
- W4360971738 hasConceptScore W4360971738C203014093 @default.
- W4360971738 hasConceptScore W4360971738C2522874641 @default.
- W4360971738 hasConceptScore W4360971738C2777701055 @default.
- W4360971738 hasConceptScore W4360971738C2778714382 @default.
- W4360971738 hasConceptScore W4360971738C67018056 @default.
- W4360971738 hasConceptScore W4360971738C71924100 @default.
- W4360971738 hasConceptScore W4360971738C83455156 @default.
- W4360971738 hasConceptScore W4360971738C90924648 @default.
- W4360971738 hasFunder F4320321001 @default.
- W4360971738 hasLocation W43609717381 @default.
- W4360971738 hasOpenAccess W4360971738 @default.
- W4360971738 hasPrimaryLocation W43609717381 @default.
- W4360971738 hasRelatedWork W2001827675 @default.
- W4360971738 hasRelatedWork W2006324759 @default.
- W4360971738 hasRelatedWork W2016973656 @default.
- W4360971738 hasRelatedWork W2027134362 @default.
- W4360971738 hasRelatedWork W2328094556 @default.
- W4360971738 hasRelatedWork W2781622362 @default.
- W4360971738 hasRelatedWork W3032481555 @default.
- W4360971738 hasRelatedWork W4246631089 @default.
- W4360971738 hasRelatedWork W4293767649 @default.
- W4360971738 hasRelatedWork W2061954776 @default.
- W4360971738 hasVolume "16" @default.
- W4360971738 isParatext "false" @default.
- W4360971738 isRetracted "false" @default.
- W4360971738 workType "article" @default.