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• W4360976304 abstract "Abstract INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD 1045 participants underwent tau scans with either 18 F-Flortaucipir, 18 F-MK6240, 18 F-PI2620, 18 F-PM-PBB3, 18 F-GTP1 or 18 F-RO948. The mask was generated from cognitively unimpaired Aβ-subjects and AD patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the global mask. A universal scale, the CenTauR z , was constructed. RESULTS None of the regions known to display off-target signal were included in the masks. The CenTauR z allows robustly discrimination between low and high levels of tau deposits. DISCUSSION We constructed several tau-specific cortical masks * for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centres. Research in Context Systematic review: The authors reviewed the literature using traditional (e.g., PubMed) sources and meeting abstracts and presentations. While the use of tau PET imaging rapidly increased in research and in clinical trials over the past few years, there is no standardization pipeline for the quantification of tau imaging across tau tracers and quantification software. Interpretation: We built a global and several regional universal masks for the sampling of tau PET scans based on the most commonly used tau PET tracers. We then derived a universal scale across tracers, the CenTauR z , to measure the tau signal. Future directions: Standardised quantification will facilitate the derivation of universal cut-off values, merging of large cohorts, and comparison of longitudinal changes across tracers and cohorts both in clinical studies and therapeutic trials." @default.
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• W4360976304 date "2023-03-26" @default.
• W4360976304 modified "2023-10-09" @default.
• W4360976304 title "CenTauR: Towards a Universal Scale and Masks for Standardizing Tau Imaging Studies" @default.
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• W4360976304 doi "https://doi.org/10.1101/2023.03.22.23287009" @default.
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