FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360976688> ?p ?o ?g. }

• W4360976688 endingPage "339" @default.
• W4360976688 startingPage "331" @default.
• W4360976688 abstract "Abstract Background The benefits of low-dose ketamine for patients with treatment-resistant depression (TRD) and prominent suicidal ideation require further investigation. The effects of treatment refractoriness, the duration of the current depressive episode, and the number of prior antidepressant failures on ketamine efficacy also require clarification. Methods We recruited 84 outpatients with TRD and prominent suicidal ideation—defined as a score ≥4 on item 10 of the Montgomery–Åsberg Depression Rating Scale (MADRS)—and randomized them into 2 groups to receive 0.5 mg/kg ketamine or 0.045 mg/kg midazolam. We assessed depressive and suicidal symptoms prior to infusion; 240 minutes post infusion; and 2, 3, 5, 7, and 14 days post infusion. Results According to the MADRS scores, the antidepressant effect (P = .035) was significantly noted in the ketamine group up to 14 days than in the midazolam group. However, the antisuicidal effect of ketamine, as measured by the Columbia-Suicide Severity Rating Scale Ideation Severity Subscale (P = .040) and MADRS item 10 (P = .023), persisted only 5 days post infusion. Furthermore, the antidepressant and antisuicidal effects of ketamine infusion were noted particularly in patients whose current depressive episode lasted &lt;24 months or whose number of failed antidepressants was ≤4. Conclusions Low-dose ketamine infusion is a safe, tolerable, and effective treatment for patients with TRD and prominent suicidal ideation. Our study highlights the importance of timing; specifically, ketamine is more likely to achieve therapeutic response when the current depressive episode lasted &lt;24 months and the number of failed antidepressants is ≤4." @default.
• W4360976688 created "2023-03-30" @default.
• W4360976688 creator A5000579005 @default.
• W4360976688 creator A5009255808 @default.
• W4360976688 creator A5017610781 @default.
• W4360976688 creator A5030780126 @default.
• W4360976688 creator A5040911954 @default.
• W4360976688 creator A5045439679 @default.
• W4360976688 creator A5045902258 @default.
• W4360976688 creator A5052719456 @default.
• W4360976688 creator A5059032985 @default.
• W4360976688 creator A5071352506 @default.
• W4360976688 creator A5090808923 @default.
• W4360976688 date "2023-03-26" @default.
• W4360976688 modified "2023-10-14" @default.
• W4360976688 title "A Randomized Double-Blind Midazolam-Controlled Trial of Low-Dose Ketamine Infusion in Patients With Treatment-Resistant Depression and Prominent Suicidal Ideation" @default.
• W4360976688 cites W1885564923 @default.
• W4360976688 cites W1965677206 @default.
• W4360976688 cites W2007445546 @default.
• W4360976688 cites W2015521528 @default.
• W4360976688 cites W2016292245 @default.
• W4360976688 cites W2108289758 @default.
• W4360976688 cites W2118625591 @default.
• W4360976688 cites W2135992410 @default.
• W4360976688 cites W2148083007 @default.
• W4360976688 cites W2148796661 @default.
• W4360976688 cites W2762798648 @default.
• W4360976688 cites W2771797851 @default.
• W4360976688 cites W2891947585 @default.
• W4360976688 cites W2894762384 @default.
• W4360976688 cites W3025905746 @default.
• W4360976688 cites W3082490768 @default.
• W4360976688 cites W3158881645 @default.
• W4360976688 cites W3166090728 @default.
• W4360976688 cites W3198279967 @default.
• W4360976688 cites W3208779045 @default.
• W4360976688 cites W4210782512 @default.
• W4360976688 cites W4281492138 @default.
• W4360976688 doi "https://doi.org/10.1093/ijnp/pyad014" @default.
• W4360976688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36966411" @default.
• W4360976688 hasPublicationYear "2023" @default.
• W4360976688 type Work @default.
• W4360976688 citedByCount "4" @default.
• W4360976688 countsByYear W43609766882023 @default.
• W4360976688 crossrefType "journal-article" @default.
• W4360976688 hasAuthorship W4360976688A5000579005 @default.
• W4360976688 hasAuthorship W4360976688A5009255808 @default.
• W4360976688 hasAuthorship W4360976688A5017610781 @default.
• W4360976688 hasAuthorship W4360976688A5030780126 @default.
• W4360976688 hasAuthorship W4360976688A5040911954 @default.
• W4360976688 hasAuthorship W4360976688A5045439679 @default.
• W4360976688 hasAuthorship W4360976688A5045902258 @default.
• W4360976688 hasAuthorship W4360976688A5052719456 @default.
• W4360976688 hasAuthorship W4360976688A5059032985 @default.
• W4360976688 hasAuthorship W4360976688A5071352506 @default.
• W4360976688 hasAuthorship W4360976688A5090808923 @default.
• W4360976688 hasBestOaLocation W43609766881 @default.
• W4360976688 hasConcept C118552586 @default.
• W4360976688 hasConcept C126322002 @default.
• W4360976688 hasConcept C138496976 @default.
• W4360976688 hasConcept C139719470 @default.
• W4360976688 hasConcept C15744967 @default.
• W4360976688 hasConcept C162324750 @default.
• W4360976688 hasConcept C168563851 @default.
• W4360976688 hasConcept C169900460 @default.
• W4360976688 hasConcept C190385971 @default.
• W4360976688 hasConcept C2776466505 @default.
• W4360976688 hasConcept C2776641880 @default.
• W4360976688 hasConcept C2776814716 @default.
• W4360976688 hasConcept C2776867660 @default.
• W4360976688 hasConcept C2777342061 @default.
• W4360976688 hasConcept C2778000748 @default.
• W4360976688 hasConcept C2779177272 @default.
• W4360976688 hasConcept C2780051608 @default.
• W4360976688 hasConcept C2780795376 @default.
• W4360976688 hasConcept C2781210005 @default.
• W4360976688 hasConcept C3017944768 @default.
• W4360976688 hasConcept C42219234 @default.
• W4360976688 hasConcept C558461103 @default.
• W4360976688 hasConcept C71924100 @default.
• W4360976688 hasConcept C83849319 @default.
• W4360976688 hasConcept C99454951 @default.
• W4360976688 hasConceptScore W4360976688C118552586 @default.
• W4360976688 hasConceptScore W4360976688C126322002 @default.
• W4360976688 hasConceptScore W4360976688C138496976 @default.
• W4360976688 hasConceptScore W4360976688C139719470 @default.
• W4360976688 hasConceptScore W4360976688C15744967 @default.
• W4360976688 hasConceptScore W4360976688C162324750 @default.
• W4360976688 hasConceptScore W4360976688C168563851 @default.
• W4360976688 hasConceptScore W4360976688C169900460 @default.
• W4360976688 hasConceptScore W4360976688C190385971 @default.
• W4360976688 hasConceptScore W4360976688C2776466505 @default.
• W4360976688 hasConceptScore W4360976688C2776641880 @default.
• W4360976688 hasConceptScore W4360976688C2776814716 @default.
• W4360976688 hasConceptScore W4360976688C2776867660 @default.
• W4360976688 hasConceptScore W4360976688C2777342061 @default.
• W4360976688 hasConceptScore W4360976688C2778000748 @default.
• W4360976688 hasConceptScore W4360976688C2779177272 @default.

• next