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• W4360977235 startingPage "111860" @default.
• W4360977235 abstract "Malignant melanoma (MM) is an aggressive and easily metastatic cancer that is poorly responsive to current therapy. The crosstalk between melanoma cells and tumor-associated adipocytes (TAA) plays an important role in the progression of MM, which could be leveraged for anticancer treatment. Here, mature adipocytes (Apo) were engineered for encapsulating a palmitic acid-conjugated triptolide derivative (pTP) and photosensitizer Ce6 (named as pTP-Ce6-Apo), to induce a cytotoxic and photodynamic treatment in malignant melanoma. After para-tumor administration, lipolysis releases pTP and Ce6 that is triggered by intracellular glutathione (GSH) and laser irradiation, respectively, subsequently inducing a variety of pathways, inducing the caspase apoptosis program; generation of reactive oxygen species (ROS), and endoplasmic reticulum (ER) stress. Overall, pTP-Ce6-Apo exhibited excellent antitumor performance and high safety, which is desired for MM therapy." @default.
• W4360977235 created "2023-03-30" @default.
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• W4360977235 date "2023-04-01" @default.
• W4360977235 modified "2023-10-11" @default.
• W4360977235 title "Engineering adipocytes for targeting delivery of triptolide derivative and Ce6 for malignant melanoma cytotoxic-PDT synergistic strategy" @default.
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• W4360977235 doi "https://doi.org/10.1016/j.matdes.2023.111860" @default.
• W4360977235 hasPublicationYear "2023" @default.
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