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- W4360981918 abstract "We have previously reported the generation of Rassf6 knockout mice using CRISPR/Cas technology. Furthermore, we have reported that RASSF6 is implicated in the regulation of the canonical nuclear factor (NF)-κB signaling pathway and that 7,12-dimethylbenz(a)anthracene induced skin inflammation in Rassf6 knockout mice more remarkably than in wild-type mice. In this study, we investigated the role of RASSF6 in skin tumorigenesis using a two-stage carcinogenesis model in Rassf6 knockout mice. Rassf6 knockout mice initially developed significantly more papillomas than did the control wild-type mice. Additionally, macrophages were detected and the canonical NF-κB signal was elevated in papillomas of Rassf6 knockout mice. These results indicated that canonical NF-κB signaling may be involved in papilloma formation. The suppression of NF-κB signaling may have implications for preventing cancer initiation and progression. The findings of this study indicate a tumor suppressive role of RASSF6." @default.
- W4360981918 created "2023-03-30" @default.
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- W4360981918 date "2023-01-01" @default.
- W4360981918 modified "2023-10-01" @default.
- W4360981918 title "Promoted Papilloma Formation in a Two-Stage Carcinogenesis Model in <i>Rassf6</i> Knockout Mice" @default.
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- W4360981918 doi "https://doi.org/10.1248/bpbreports.6.2_43" @default.
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