FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360982811> ?p ?o ?g. }

• W4360982811 abstract "Abstract Glaucoma is a chronic neurodegenerative process of the optic nerve that is the leading cause of blindness worldwide, and early diagnosis of the disease could greatly affect patients’ prognoses. The pathophysiology of glaucoma is complicated by a combination of genetic and epigenetic factors. Deciphering the early diagnostic biomarkers in glaucoma could attenuate the disease's global burden and help us understand the exact mechanisms involved in glaucoma. The microRNAs are members of a larger family of non-coding RNAs that play an essential role in the epigenetic basis of glaucoma. A systematic study and meta-analysis of diagnostic microRNAs in glaucoma, jointly with network analysis of target genes, were carried out on published papers assessing differentially expressed microRNAs in human subjects. In total, 321 articles were found, and, after screening, six studies were eligible for further analysis. 52 differentially expressed microRNAs were found, of which 28 and 24 were up-regulated and down-regulated, respectively. Only 12 microRNAs were qualified for meta-analysis, with overall sensitivity and specificity of 80% and 74%, respectively. Then, using network analysis, it became apparent that the VEGF-A, AKT1, CXCL12, and HRAS genes were the most important targets for the microRNAs. Perturbations in WNT signaling, protein transport, and extracellular matrix organization pathways were discovered to be important in the etiology of glaucoma using the community detection approach. This study tries to uncover the promising microRNAs and their target genes that govern the epigenetics of glaucoma." @default.
• W4360982811 created "2023-03-30" @default.
• W4360982811 creator A5002080900 @default.
• W4360982811 creator A5023556051 @default.
• W4360982811 creator A5074256646 @default.
• W4360982811 creator A5077083722 @default.
• W4360982811 creator A5080762911 @default.
• W4360982811 creator A5086170750 @default.
• W4360982811 date "2023-03-27" @default.
• W4360982811 modified "2023-10-05" @default.
• W4360982811 title "A systematic review, meta-analysis, and network analysis of diagnostic microRNAs in glaucoma" @default.
• W4360982811 cites W1520066951 @default.
• W4360982811 cites W1970240942 @default.
• W4360982811 cites W1970320378 @default.
• W4360982811 cites W1989981922 @default.
• W4360982811 cites W2009274826 @default.
• W4360982811 cites W2019986404 @default.
• W4360982811 cites W2034742711 @default.
• W4360982811 cites W2040116142 @default.
• W4360982811 cites W2052911528 @default.
• W4360982811 cites W2057266151 @default.
• W4360982811 cites W2058006061 @default.
• W4360982811 cites W2062907983 @default.
• W4360982811 cites W2070050178 @default.
• W4360982811 cites W2082871536 @default.
• W4360982811 cites W2086876060 @default.
• W4360982811 cites W2103586281 @default.
• W4360982811 cites W2107638293 @default.
• W4360982811 cites W2108002194 @default.
• W4360982811 cites W2139791626 @default.
• W4360982811 cites W2146819974 @default.
• W4360982811 cites W2159064660 @default.
• W4360982811 cites W2174734928 @default.
• W4360982811 cites W2193183716 @default.
• W4360982811 cites W2332566777 @default.
• W4360982811 cites W2407915694 @default.
• W4360982811 cites W2470233900 @default.
• W4360982811 cites W2568830242 @default.
• W4360982811 cites W2580076333 @default.
• W4360982811 cites W2612597684 @default.
• W4360982811 cites W2761604622 @default.
• W4360982811 cites W2790716032 @default.
• W4360982811 cites W2796272779 @default.
• W4360982811 cites W2883126002 @default.
• W4360982811 cites W2892076417 @default.
• W4360982811 cites W2902238727 @default.
• W4360982811 cites W2911008581 @default.
• W4360982811 cites W2947223074 @default.
• W4360982811 cites W2960053812 @default.
• W4360982811 cites W2966321063 @default.
• W4360982811 cites W3001041847 @default.
• W4360982811 cites W3014690129 @default.
• W4360982811 cites W3137066459 @default.
• W4360982811 cites W3165395345 @default.
• W4360982811 cites W3175855358 @default.
• W4360982811 cites W3187227956 @default.
• W4360982811 cites W3188971174 @default.
• W4360982811 cites W4223512969 @default.
• W4360982811 cites W4255156463 @default.
• W4360982811 cites W4283030715 @default.
• W4360982811 doi "https://doi.org/10.1186/s40001-023-01093-8" @default.
• W4360982811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36973823" @default.
• W4360982811 hasPublicationYear "2023" @default.
• W4360982811 type Work @default.
• W4360982811 citedByCount "1" @default.
• W4360982811 crossrefType "journal-article" @default.
• W4360982811 hasAuthorship W4360982811A5002080900 @default.
• W4360982811 hasAuthorship W4360982811A5023556051 @default.
• W4360982811 hasAuthorship W4360982811A5074256646 @default.
• W4360982811 hasAuthorship W4360982811A5077083722 @default.
• W4360982811 hasAuthorship W4360982811A5080762911 @default.
• W4360982811 hasAuthorship W4360982811A5086170750 @default.
• W4360982811 hasBestOaLocation W43609828111 @default.
• W4360982811 hasConcept C104317684 @default.
• W4360982811 hasConcept C118487528 @default.
• W4360982811 hasConcept C142724271 @default.
• W4360982811 hasConcept C145059251 @default.
• W4360982811 hasConcept C2778527774 @default.
• W4360982811 hasConcept C2779134260 @default.
• W4360982811 hasConcept C41091548 @default.
• W4360982811 hasConcept C54355233 @default.
• W4360982811 hasConcept C60644358 @default.
• W4360982811 hasConcept C71924100 @default.
• W4360982811 hasConcept C86803240 @default.
• W4360982811 hasConceptScore W4360982811C104317684 @default.
• W4360982811 hasConceptScore W4360982811C118487528 @default.
• W4360982811 hasConceptScore W4360982811C142724271 @default.
• W4360982811 hasConceptScore W4360982811C145059251 @default.
• W4360982811 hasConceptScore W4360982811C2778527774 @default.
• W4360982811 hasConceptScore W4360982811C2779134260 @default.
• W4360982811 hasConceptScore W4360982811C41091548 @default.
• W4360982811 hasConceptScore W4360982811C54355233 @default.
• W4360982811 hasConceptScore W4360982811C60644358 @default.
• W4360982811 hasConceptScore W4360982811C71924100 @default.
• W4360982811 hasConceptScore W4360982811C86803240 @default.
• W4360982811 hasIssue "1" @default.
• W4360982811 hasLocation W43609828111 @default.
• W4360982811 hasLocation W43609828112 @default.
• W4360982811 hasLocation W43609828113 @default.
• W4360982811 hasOpenAccess W4360982811 @default.

• next