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- W4360983032 abstract "Abstract Background The aim of this study was to explore the mechanism of complement C3a mediating podocyte injury during ischemia–reperfusion acute kidney injury (IR-AKI) and post-injury fibrosis. Methods Renal artery clamping was used to establish IR-AKI and post-injury fibrosis model. HE and Masson staining were performed to observe renal fibrosis. The protein abundance levels were measured along with inflammatory markers, renal complement C3. Podocytes were treated with C3a with or without Toll-like receptor 4(TLR4) inhibitor. The effects of TLR4 up-regulation by TLR4 plasmids were examined. Results C3 −/− resulted in amelioration of renal dysfunction by reducing podocyte damage and renal fibrosis. Immunoblot with renal tissue homogenates from IR-AKI mice revealed that C3 −/− decreased TLR4/Nuclear Factor-κB (NFκB)-P65. Conclusion Our results indicate that modulating C3/TLR4/NFκB-P65 signaling pathway is a novel therapeutic target for the IR-AKI and post-injury fibrosis. Graphical Abstract" @default.
- W4360983032 created "2023-03-30" @default.
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- W4360983032 date "2023-03-27" @default.
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- W4360983032 title "Complement C3 mediates podocyte injury through TLR4/NFΚB-P65 signaling during ischemia–reperfusion acute kidney injury and post-injury fibrosis" @default.
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- W4360983032 doi "https://doi.org/10.1186/s40001-023-01054-1" @default.
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