FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360984889> ?p ?o ?g. }

• W4360984889 abstract "Background: Breast cancer (BRCA) is regarded as a lethal and aggressive cancer with increasing morbidity and mortality worldwide. cGAS-STING signaling regulates the crosstalk between tumor cells and immune cells in the tumor microenvironment (TME), emerging as an important DNA-damage mechanism. However, cGAS-STING-related genes (CSRGs) have rarely been investigated for their prognostic value in breast cancer patients. Methods: Our study aimed to construct a risk model to predict the survival and prognosis of breast cancer patients. We obtained 1087 breast cancer samples and 179 normal breast tissue samples from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEX) database, 35 immune-related differentially expression genes (DEGs) from cGAS-STING-related genes were systematically assessed. The Cox regression was applied for further selection, and 11 prognostic-related DEGs were used to develop a machine learning-based risk assessment and prognostic model. Results: We successfully developed a risk model to predict the prognostic value of breast cancer patients and its performance acquired effective validation. The results derived from Kaplan-Meier analysis revealed that the low-risk score patients had better overall survival (OS). The nomogram that integrated the risk score and clinical information was established and had good validity in predicting the overall survival of breast cancer patients. Significant correlations were observed between the risk score and tumor-infiltrating immune cells, immune checkpoints and the response to immunotherapy. The cGAS-STING-related genes risk score was also relevant to a series of clinic prognostic indicators such as tumor staging, molecular subtype, tumor recurrence, and drug therapeutic sensibility in breast cancer patients. Conclusion: cGAS-STING-related genes risk model provides a new credible risk stratification method to improve the clinical prognostic assessment for breast cancer." @default.
• W4360984889 created "2023-03-30" @default.
• W4360984889 creator A5011648324 @default.
• W4360984889 creator A5028096179 @default.
• W4360984889 creator A5048708984 @default.
• W4360984889 creator A5063253432 @default.
• W4360984889 creator A5085349414 @default.
• W4360984889 date "2023-03-27" @default.
• W4360984889 modified "2023-10-02" @default.
• W4360984889 title "Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes" @default.
• W4360984889 cites W1559117436 @default.
• W4360984889 cites W1570622790 @default.
• W4360984889 cites W1948324417 @default.
• W4360984889 cites W1976199086 @default.
• W4360984889 cites W2035618305 @default.
• W4360984889 cites W2042699075 @default.
• W4360984889 cites W2091144643 @default.
• W4360984889 cites W2099610218 @default.
• W4360984889 cites W2110146199 @default.
• W4360984889 cites W2114586150 @default.
• W4360984889 cites W2130410032 @default.
• W4360984889 cites W2130430382 @default.
• W4360984889 cites W2132413371 @default.
• W4360984889 cites W2144432202 @default.
• W4360984889 cites W2150770343 @default.
• W4360984889 cites W2152644043 @default.
• W4360984889 cites W2157058802 @default.
• W4360984889 cites W2157076315 @default.
• W4360984889 cites W2170137783 @default.
• W4360984889 cites W2170637386 @default.
• W4360984889 cites W2177870565 @default.
• W4360984889 cites W2179438025 @default.
• W4360984889 cites W2221588520 @default.
• W4360984889 cites W2232693424 @default.
• W4360984889 cites W2269332562 @default.
• W4360984889 cites W2521963431 @default.
• W4360984889 cites W2522054472 @default.
• W4360984889 cites W2728753419 @default.
• W4360984889 cites W2742007963 @default.
• W4360984889 cites W2744067212 @default.
• W4360984889 cites W2761586559 @default.
• W4360984889 cites W2762285338 @default.
• W4360984889 cites W2767600184 @default.
• W4360984889 cites W2771759088 @default.
• W4360984889 cites W2795867722 @default.
• W4360984889 cites W2795989238 @default.
• W4360984889 cites W2801309958 @default.
• W4360984889 cites W2811281203 @default.
• W4360984889 cites W2854081253 @default.
• W4360984889 cites W2886498337 @default.
• W4360984889 cites W2886522935 @default.
• W4360984889 cites W2889598160 @default.
• W4360984889 cites W2897257669 @default.
• W4360984889 cites W2902185751 @default.
• W4360984889 cites W2903686952 @default.
• W4360984889 cites W2909301717 @default.
• W4360984889 cites W2914311347 @default.
• W4360984889 cites W2920600229 @default.
• W4360984889 cites W2923540337 @default.
• W4360984889 cites W2932331988 @default.
• W4360984889 cites W2942610007 @default.
• W4360984889 cites W2980392895 @default.
• W4360984889 cites W2995171541 @default.
• W4360984889 cites W3003773438 @default.
• W4360984889 cites W3010217167 @default.
• W4360984889 cites W3036927511 @default.
• W4360984889 cites W3041348098 @default.
• W4360984889 cites W3042355687 @default.
• W4360984889 cites W3052573234 @default.
• W4360984889 cites W3080399909 @default.
• W4360984889 cites W3090711812 @default.
• W4360984889 cites W3092326634 @default.
• W4360984889 cites W3109382696 @default.
• W4360984889 cites W3111020808 @default.
• W4360984889 cites W3122448411 @default.
• W4360984889 cites W3128438940 @default.
• W4360984889 cites W3132656131 @default.
• W4360984889 cites W3172174831 @default.
• W4360984889 cites W3172911572 @default.
• W4360984889 cites W3182293965 @default.
• W4360984889 cites W3195317511 @default.
• W4360984889 cites W3198735776 @default.
• W4360984889 cites W4210510690 @default.
• W4360984889 cites W4211032970 @default.
• W4360984889 cites W4211163163 @default.
• W4360984889 cites W4281559326 @default.
• W4360984889 cites W4281704495 @default.
• W4360984889 cites W4282975734 @default.
• W4360984889 cites W4287577366 @default.
• W4360984889 cites W4290988577 @default.
• W4360984889 cites W4292544138 @default.
• W4360984889 cites W4293182157 @default.
• W4360984889 cites W4293200198 @default.
• W4360984889 cites W4294844433 @default.
• W4360984889 cites W4300960603 @default.
• W4360984889 cites W4303614109 @default.
• W4360984889 cites W4306165439 @default.
• W4360984889 cites W4306641739 @default.
• W4360984889 cites W4308126377 @default.
• W4360984889 cites W4309755975 @default.

• next