Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360984908> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4360984908 abstract "Objectives In a COVID-19 sero-surveillance cohort study with predominantly healthy and vaccinated individuals, the objectives were (i) to investigate longitudinally the factors associated with the quantitative dynamics of anti-spike IgG antibody levels, (ii) to evaluate whether the antibody levels were associated with protection from SARS-CoV-2 infection and (iii) to assess whether the association was different in the pre-Omicron compared with the Omicron period. Methods The QuantiVac Euroimmun ELISA test was used to quantify anti-S1 IgG levels. The entire study period (16 months), the 11-month pre-Omicron period and the cross-sectional analysis prior to the Omicron surge included 3219, 2310 and 895 reactive serum samples from 949, 919 and 895 study participants, respectively. Mixed-effect linear, mixed-effect time-to-event and logistic regression models were used to achieve the objectives. Results Age and time since infection or vaccination were the only factors associated with a decline of anti-S1 IgG levels. Antibody levels were significantly associated with protection from SARS-CoV-2 infection, and the association was higher for the Omicron than for the Alpha and Delta variants. In a prediction model, it was estimated that >8000 BAU/mL anti-S1 IgG was required to reduce the risk of infection with Omicron variants by 20% to 30% for 90 days. Conclusions Anti-S1 IgG antibody levels are associated with protection from infection. The levels in the pre-Omicron periods were less significant than during the Omicron surge, which in turn required very high levels for protection in a statistical model." @default.
- W4360984908 created "2023-03-30" @default.
- W4360984908 creator A5000180671 @default.
- W4360984908 creator A5002059133 @default.
- W4360984908 creator A5023022594 @default.
- W4360984908 creator A5024971361 @default.
- W4360984908 creator A5027757394 @default.
- W4360984908 creator A5037339313 @default.
- W4360984908 creator A5038122865 @default.
- W4360984908 creator A5050168815 @default.
- W4360984908 creator A5051530432 @default.
- W4360984908 creator A5053382062 @default.
- W4360984908 creator A5061331621 @default.
- W4360984908 creator A5067255087 @default.
- W4360984908 creator A5077875571 @default.
- W4360984908 creator A5085091326 @default.
- W4360984908 creator A5085951172 @default.
- W4360984908 creator A5090936485 @default.
- W4360984908 date "2023-03-27" @default.
- W4360984908 modified "2023-09-28" @default.
- W4360984908 title "Do Quantitative Levels of Anti-Spike-IgG Antibodies Aid in Predicting Protection from SARS-CoV-2 Infection? Results from a Longitudinal Study in a Police Cohort" @default.
- W4360984908 doi "https://doi.org/10.22541/au.167989329.99688527/v1" @default.
- W4360984908 hasPublicationYear "2023" @default.
- W4360984908 type Work @default.
- W4360984908 citedByCount "0" @default.
- W4360984908 crossrefType "posted-content" @default.
- W4360984908 hasAuthorship W4360984908A5000180671 @default.
- W4360984908 hasAuthorship W4360984908A5002059133 @default.
- W4360984908 hasAuthorship W4360984908A5023022594 @default.
- W4360984908 hasAuthorship W4360984908A5024971361 @default.
- W4360984908 hasAuthorship W4360984908A5027757394 @default.
- W4360984908 hasAuthorship W4360984908A5037339313 @default.
- W4360984908 hasAuthorship W4360984908A5038122865 @default.
- W4360984908 hasAuthorship W4360984908A5050168815 @default.
- W4360984908 hasAuthorship W4360984908A5051530432 @default.
- W4360984908 hasAuthorship W4360984908A5053382062 @default.
- W4360984908 hasAuthorship W4360984908A5061331621 @default.
- W4360984908 hasAuthorship W4360984908A5067255087 @default.
- W4360984908 hasAuthorship W4360984908A5077875571 @default.
- W4360984908 hasAuthorship W4360984908A5085091326 @default.
- W4360984908 hasAuthorship W4360984908A5085951172 @default.
- W4360984908 hasAuthorship W4360984908A5090936485 @default.
- W4360984908 hasBestOaLocation W43609849081 @default.
- W4360984908 hasConcept C126322002 @default.
- W4360984908 hasConcept C151956035 @default.
- W4360984908 hasConcept C159047783 @default.
- W4360984908 hasConcept C159654299 @default.
- W4360984908 hasConcept C203014093 @default.
- W4360984908 hasConcept C22070199 @default.
- W4360984908 hasConcept C2779134260 @default.
- W4360984908 hasConcept C3007834351 @default.
- W4360984908 hasConcept C3008058167 @default.
- W4360984908 hasConcept C524204448 @default.
- W4360984908 hasConcept C71924100 @default.
- W4360984908 hasConcept C72563966 @default.
- W4360984908 hasConceptScore W4360984908C126322002 @default.
- W4360984908 hasConceptScore W4360984908C151956035 @default.
- W4360984908 hasConceptScore W4360984908C159047783 @default.
- W4360984908 hasConceptScore W4360984908C159654299 @default.
- W4360984908 hasConceptScore W4360984908C203014093 @default.
- W4360984908 hasConceptScore W4360984908C22070199 @default.
- W4360984908 hasConceptScore W4360984908C2779134260 @default.
- W4360984908 hasConceptScore W4360984908C3007834351 @default.
- W4360984908 hasConceptScore W4360984908C3008058167 @default.
- W4360984908 hasConceptScore W4360984908C524204448 @default.
- W4360984908 hasConceptScore W4360984908C71924100 @default.
- W4360984908 hasConceptScore W4360984908C72563966 @default.
- W4360984908 hasLocation W43609849081 @default.
- W4360984908 hasOpenAccess W4360984908 @default.
- W4360984908 hasPrimaryLocation W43609849081 @default.
- W4360984908 hasRelatedWork W2603773853 @default.
- W4360984908 hasRelatedWork W3032377983 @default.
- W4360984908 hasRelatedWork W3036305013 @default.
- W4360984908 hasRelatedWork W3092537164 @default.
- W4360984908 hasRelatedWork W3178186717 @default.
- W4360984908 hasRelatedWork W3184386184 @default.
- W4360984908 hasRelatedWork W4205317059 @default.
- W4360984908 hasRelatedWork W4206669628 @default.
- W4360984908 hasRelatedWork W4210401150 @default.
- W4360984908 hasRelatedWork W4287374796 @default.
- W4360984908 isParatext "false" @default.
- W4360984908 isRetracted "false" @default.
- W4360984908 workType "article" @default.