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• W4360985323 abstract "Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart failure, and ischemia-reperfusion injury. Extensive literature also suggested its protective functions in several central nervous system disorders. Sigmar1’s molecular functions in the pulmonary system remained unknown. Therefore, we aimed to determine the expression of Sigmar1 in the lungs. We also examined whether Sigmar1 ablation results in histological, ultrastructural, and biochemical changes associated with lung pathology over aging in mice. In the current study, we first confirmed the presence of Sigmar1 protein in human and mouse lungs using immunohistochemistry and immunostaining. We used the Sigmar1 global knockout mouse (Sigmar1 −/− ) to determine the pathophysiological role of Sigmar1 in lungs over aging. The histological staining of lung sections showed altered alveolar structures, higher immune cells infiltration, and upregulation of inflammatory markers (such as pNFκB) in Sigmar1 −/− mice compared to wildtype (Wt) littermate control mice (Wt). This indicates higher pulmonary inflammation resulting from Sigmar1 deficiency in mice, which was associated with increased pulmonary fibrosis. The protein levels of some fibrotic markers, fibronectin, and pSMAD2 Ser 245/250/255 and Ser 465/467, were also elevated in mice lungs in the absence of Sigmar1 compared to Wt. The ultrastructural analysis of lungs in Wt mice showed numerous multilamellar bodies of different sizes with densely packed lipid lamellae and mitochondria with a dark matrix and dense cristae. In contrast, the Sigmar1 −/− mice lung tissues showed altered multilamellar body structures in alveolar epithelial type-II pneumocytes with partial loss of lipid lamellae structures in the lamellar bodies. This was further associated with higher protein levels of all four surfactant proteins, SFTP-A, SFTP-B, SFTP-C, and SFTP-D, in the Sigmar1 −/− mice lungs. This is the first study showing Sigmar1’s expression pattern in human and mouse lungs and its association with lung pathophysiology. Our findings suggest that Sigmar1 deficiency leads to increased pulmonary inflammation, higher pulmonary fibrosis, alterations of the multilamellar body stuructures, and elevated levels of lung surfactant proteins." @default.
• W4360985323 created "2023-03-30" @default.
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• W4360985323 date "2023-03-27" @default.
• W4360985323 modified "2023-10-18" @default.
• W4360985323 title "Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels" @default.
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• W4360985323 cites W1490103016 @default.
• W4360985323 cites W1601809166 @default.
• W4360985323 cites W1900414416 @default.
• W4360985323 cites W1928953268 @default.
• W4360985323 cites W1960147035 @default.
• W4360985323 cites W1965060071 @default.
• W4360985323 cites W1972323338 @default.
• W4360985323 cites W1987210736 @default.
• W4360985323 cites W1989159174 @default.
• W4360985323 cites W1990842136 @default.
• W4360985323 cites W1990990523 @default.
• W4360985323 cites W2000516637 @default.
• W4360985323 cites W2003532781 @default.
• W4360985323 cites W2007312501 @default.
• W4360985323 cites W2008206381 @default.
• W4360985323 cites W2013048025 @default.
• W4360985323 cites W2025859335 @default.
• W4360985323 cites W2026692772 @default.
• W4360985323 cites W2027105757 @default.
• W4360985323 cites W2031334428 @default.
• W4360985323 cites W2032922952 @default.
• W4360985323 cites W2034032685 @default.
• W4360985323 cites W2037787328 @default.
• W4360985323 cites W2046990892 @default.
• W4360985323 cites W2054597500 @default.
• W4360985323 cites W2059601647 @default.
• W4360985323 cites W2060200915 @default.
• W4360985323 cites W2075213739 @default.
• W4360985323 cites W2082866035 @default.
• W4360985323 cites W2089351812 @default.
• W4360985323 cites W2090267247 @default.
• W4360985323 cites W2090739278 @default.
• W4360985323 cites W2096563123 @default.
• W4360985323 cites W2099970328 @default.
• W4360985323 cites W2106322477 @default.
• W4360985323 cites W2106858531 @default.
• W4360985323 cites W2118897192 @default.
• W4360985323 cites W2122588015 @default.
• W4360985323 cites W2128754068 @default.
• W4360985323 cites W2129224957 @default.
• W4360985323 cites W2130416012 @default.
• W4360985323 cites W2133272331 @default.
• W4360985323 cites W2135855797 @default.
• W4360985323 cites W2155611657 @default.
• W4360985323 cites W2155835417 @default.
• W4360985323 cites W2161578215 @default.
• W4360985323 cites W2167069175 @default.
• W4360985323 cites W2169525045 @default.
• W4360985323 cites W2297680301 @default.
• W4360985323 cites W2302524766 @default.
• W4360985323 cites W2336382631 @default.
• W4360985323 cites W2337913455 @default.
• W4360985323 cites W2409139791 @default.
• W4360985323 cites W2418460495 @default.
• W4360985323 cites W246668958 @default.
• W4360985323 cites W2469536647 @default.
• W4360985323 cites W2507429131 @default.
• W4360985323 cites W2519867542 @default.
• W4360985323 cites W2599923511 @default.
• W4360985323 cites W2724944844 @default.
• W4360985323 cites W2895936122 @default.
• W4360985323 cites W2914443670 @default.
• W4360985323 cites W2918537913 @default.
• W4360985323 cites W3009604307 @default.
• W4360985323 cites W3022285953 @default.
• W4360985323 cites W3093213262 @default.
• W4360985323 cites W3095229760 @default.
• W4360985323 cites W3101705429 @default.
• W4360985323 cites W3132351877 @default.
• W4360985323 cites W3182763960 @default.
• W4360985323 cites W3208959641 @default.
• W4360985323 cites W4200097793 @default.
• W4360985323 cites W4205838638 @default.
• W4360985323 cites W4206721202 @default.
• W4360985323 doi "https://doi.org/10.3389/fphys.2023.1118770" @default.
• W4360985323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37051024" @default.
• W4360985323 hasPublicationYear "2023" @default.
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