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- W4360989459 abstract "Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood-brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area." @default.
- W4360989459 created "2023-03-30" @default.
- W4360989459 creator A5017520028 @default.
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- W4360989459 creator A5043652085 @default.
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- W4360989459 date "2023-03-27" @default.
- W4360989459 modified "2023-09-30" @default.
- W4360989459 title "Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment" @default.
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