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- W4360989475 abstract "Abstract Deterministic lateral displacement (DLD) is a promising technology that allows for the continuous and the size-based separation of suspended particles at a high resolution through periodically arrayed micropillars. In conventional DLD, the critical diameter ( D c ), which determines the migration mode of a particle of a particular size, is fixed by the device geometry. Here, we propose a novel DLD that uses the pillars of a thermo-responsive hydrogel, poly( N -isopropylacrylamide) (PNIPAM) to flexibly tune the D c value. Upon heating and cooling, the PNIPAM pillars in the aqueous solution shrink and swell because of their hydrophobic-hydrophilic phase transitions as the temperature varies. Using the PNIPAM pillars confined in a poly(dimethylsiloxane) microchannel, we demonstrate continuous switching of particle (7-μm beads) trajectories (displacement or zigzag mode) by adjusting the D c through temperature control of the device on a Peltier element. Further, we perform on/off operation of the particle separation (7-μm and 2-μm beads) by adjusting the D c values." @default.
- W4360989475 created "2023-03-30" @default.
- W4360989475 creator A5047775919 @default.
- W4360989475 creator A5063888189 @default.
- W4360989475 date "2023-03-27" @default.
- W4360989475 modified "2023-09-25" @default.
- W4360989475 title "Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays" @default.
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- W4360989475 doi "https://doi.org/10.1038/s41598-023-32233-z" @default.
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