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- W4360989592 abstract "Hexokinases (HKs) convert hexose sugars to hexose-6-phosphate, thus trapping them inside cells to meet the synthetic and energetic demands. HKs participate in various standard and altered physiological processes, including cancer, primarily through the reprogramming of cellular metabolism. Four canonical HKs have been identified with different expression patterns across tissues. HKs 1-3 play a role in glucose utilization, whereas HK 4 (glucokinase, GCK) also acts as a glucose sensor. Recently, a novel 5th HK, hexokinase domain containing 1 (HKDC1), has been identified, which plays a role in whole-body glucose utilization and insulin sensitivity. Beyond the metabolic functions, HKDC1 is differentially expressed in many forms of human cancer. This review focuses on the role of HKs, particularly HKDC1, in metabolic reprogramming and cancer progression." @default.
- W4360989592 created "2023-03-30" @default.
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- W4360989592 date "2023-03-27" @default.
- W4360989592 modified "2023-10-02" @default.
- W4360989592 title "Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic Reprogramming" @default.
- W4360989592 doi "https://doi.org/10.20944/preprints202303.0440.v1" @default.
- W4360989592 hasPublicationYear "2023" @default.
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