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- W4360990580 abstract "The aim of this study was to demonstrate the clinical feasibility of intraoperative additional photodynamic therapy (PDT) using talaporfin sodium and a semiconductor laser in patients with malignant meningeal tumors. 14 patients (Male / Female: 5 / 9, aged 41 to 80 y.o.) were enrolled in this study. Except for 1 case, almost all cases are recurrent meningeal tumor usually demonstrated the long clinical history, median 60 (11 to 420) months, including multiple surgery and radiotherapy. The locations of these tumors were parasagittal/ convexity 7, middle fossa/petrous 3, cerebellopontine angle 3 and tentorium cerebelli 1. Except for 3 cases of hemangiopericytoma/solitary fibrous tumor Grade III, 10 cases were consisted of 4 atypical and 6 anaplastic meningioma. The method of PDT was identical to the reported one for malignant glioma cases. (Akimoto J, Neurol Med Chir 2016). 4 cases were performed repeat resection with PDT for repeated recurrence. The resection rate of 19 times of surgery were total resection 1, Simpson Grade II 7 and Grade IV 11 cases, respectively. The median follow up period from first PDT was 23.5 (6 to 45) months. The average number of laser irradiation to the attached dura mater or invading brain tissue was 8.8 (2 to 29). Except for 1 case of 6 months survival time with 15 years clinical history and 3 cases of 2 to 3 years survival time, other 10 cases were still alive. No adverse events directly attributable to PDT occurred in any patients. Protection against light was only required for approximately 7 days after PDT. There are few therapeutic strategies of recurrent atypical/anaplastic meningeal tumor. It is an urgent issue to develop the effective local treatment to manage these complicated tumors. The results of the present study suggest that PDT with talaporfin sodium provides excellent local control without adverse event for patients with malignant meningeal tumors." @default.
- W4360990580 created "2023-03-30" @default.
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- W4360990580 date "2023-03-01" @default.
- W4360990580 modified "2023-10-17" @default.
- W4360990580 title "Efficacy and safety of photodynamic therapy using talaporfin sodium and a semiconductor laser in patients with malignant meningeal tumors" @default.
- W4360990580 doi "https://doi.org/10.1016/j.pdpdt.2023.103418" @default.
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