Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360991388> ?p ?o ?g. }
- W4360991388 abstract "Abstract The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between commensal micro-organisms and pathogens. Checkpoint inhibitors (CPI), particularly those targeting the CTLA-4 pathway, disrupt this fine balance and can lead to inflammatory bowel disease (IBD) and immune checkpoint colitis (CPI-C). Here, we show that CTLA-4 is expressed by innate lymphoid cells (ILC) and that its expression is regulated by ILC subset-specific cytokine cues in a microbiota-dependent manner. Genetic deletion or antibody blockade of CTLA-4 demonstrates that this pathway plays a key role in intestinal homeostasis and is conserved in human IBD and CPI-induced colitis (CPI-C). We propose that this population of CTLA-4-positive ILC may serve as an important target for the treatment of idiopathic and iatrogenic intestinal inflammation." @default.
- W4360991388 created "2023-03-30" @default.
- W4360991388 creator A5002092452 @default.
- W4360991388 creator A5006988780 @default.
- W4360991388 creator A5011513198 @default.
- W4360991388 creator A5013066121 @default.
- W4360991388 creator A5015262622 @default.
- W4360991388 creator A5025153602 @default.
- W4360991388 creator A5031358012 @default.
- W4360991388 creator A5031605277 @default.
- W4360991388 creator A5032060766 @default.
- W4360991388 creator A5050251296 @default.
- W4360991388 creator A5053622449 @default.
- W4360991388 creator A5057994476 @default.
- W4360991388 creator A5059369253 @default.
- W4360991388 creator A5060939938 @default.
- W4360991388 creator A5063545180 @default.
- W4360991388 creator A5065809735 @default.
- W4360991388 creator A5073149983 @default.
- W4360991388 creator A5077435410 @default.
- W4360991388 creator A5078878021 @default.
- W4360991388 creator A5078956440 @default.
- W4360991388 creator A5086368104 @default.
- W4360991388 creator A5090368018 @default.
- W4360991388 date "2023-03-27" @default.
- W4360991388 modified "2023-10-10" @default.
- W4360991388 title "Microbiota-dependent expression of CTLA-4 by innate lymphoid cells restrains IFNγ dependent colitis" @default.
- W4360991388 cites W1579108180 @default.
- W4360991388 cites W1581904411 @default.
- W4360991388 cites W1650516212 @default.
- W4360991388 cites W1899646506 @default.
- W4360991388 cites W1967067685 @default.
- W4360991388 cites W1977099733 @default.
- W4360991388 cites W1987735044 @default.
- W4360991388 cites W1993339415 @default.
- W4360991388 cites W1993734178 @default.
- W4360991388 cites W1994875855 @default.
- W4360991388 cites W1996217426 @default.
- W4360991388 cites W1998440908 @default.
- W4360991388 cites W2006711580 @default.
- W4360991388 cites W2015085911 @default.
- W4360991388 cites W2024183493 @default.
- W4360991388 cites W2026092903 @default.
- W4360991388 cites W2028057905 @default.
- W4360991388 cites W2033289727 @default.
- W4360991388 cites W2051148575 @default.
- W4360991388 cites W2054978125 @default.
- W4360991388 cites W2055897422 @default.
- W4360991388 cites W2061071534 @default.
- W4360991388 cites W2076067786 @default.
- W4360991388 cites W2081255498 @default.
- W4360991388 cites W2085332498 @default.
- W4360991388 cites W2087013294 @default.
- W4360991388 cites W2087482409 @default.
- W4360991388 cites W2092233067 @default.
- W4360991388 cites W2097995306 @default.
- W4360991388 cites W2100117872 @default.
- W4360991388 cites W2106426147 @default.
- W4360991388 cites W2106790228 @default.
- W4360991388 cites W2116846792 @default.
- W4360991388 cites W2128440308 @default.
- W4360991388 cites W2129235766 @default.
- W4360991388 cites W2130822830 @default.
- W4360991388 cites W2134638467 @default.
- W4360991388 cites W2136221987 @default.
- W4360991388 cites W2146890677 @default.
- W4360991388 cites W2152897456 @default.
- W4360991388 cites W2155395286 @default.
- W4360991388 cites W2155997615 @default.
- W4360991388 cites W2156268588 @default.
- W4360991388 cites W2160966000 @default.
- W4360991388 cites W2162856391 @default.
- W4360991388 cites W2165456770 @default.
- W4360991388 cites W2168612089 @default.
- W4360991388 cites W2179676503 @default.
- W4360991388 cites W2190545194 @default.
- W4360991388 cites W2263759961 @default.
- W4360991388 cites W2275606382 @default.
- W4360991388 cites W2328151595 @default.
- W4360991388 cites W2418354692 @default.
- W4360991388 cites W2560624107 @default.
- W4360991388 cites W2594042408 @default.
- W4360991388 cites W2601055810 @default.
- W4360991388 cites W2614467908 @default.
- W4360991388 cites W2616369527 @default.
- W4360991388 cites W2737457272 @default.
- W4360991388 cites W2742763599 @default.
- W4360991388 cites W2743419024 @default.
- W4360991388 cites W2746722198 @default.
- W4360991388 cites W2766903152 @default.
- W4360991388 cites W2767343890 @default.
- W4360991388 cites W2779119900 @default.
- W4360991388 cites W2792937256 @default.
- W4360991388 cites W2890689561 @default.
- W4360991388 cites W2892132049 @default.
- W4360991388 cites W2898631010 @default.
- W4360991388 cites W2903493423 @default.
- W4360991388 cites W2907514116 @default.
- W4360991388 cites W2949177718 @default.
- W4360991388 cites W2979460593 @default.