FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360992703> ?p ?o ?g. }

• W4360992703 endingPage "5142" @default.
• W4360992703 startingPage "5136" @default.
• W4360992703 abstract "4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27; HPPD) represents a potential target for novel herbicide development. To discover the more promising HPPD inhibitor, we designed and synthesized a series of bis-5-cyclopropylisoxazole-4-carboxamides with different linkers using a multitarget pesticide design strategy. Among them, compounds b9 and b10 displayed excellent herbicidal activities versus Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR) with the inhibition of about 90% at the concentration of 100 mg/L in vitro, which was better than that of isoxaflutole (IFT). Furthermore, compounds b9 and b10 displayed the best inhibitory effect versus DS and AR with the inhibition of about 90 and 85% at 90 g (ai)/ha in the greenhouse, respectively. The structure–activity relationship study showed that the flexible linker (6 carbon atoms) is responsible for increasing their herbicidal activity. The molecular docking analyses showed that compounds b9 and b10 could more closely bind to the active site of HPPD and thus exhibited a better inhibitory effect. Altogether, these results indicated that compounds b9 and b10 could be used as potential herbicide candidates targeting HPPD." @default.
• W4360992703 created "2023-03-30" @default.
• W4360992703 creator A5022475239 @default.
• W4360992703 creator A5037824478 @default.
• W4360992703 creator A5042036814 @default.
• W4360992703 creator A5043489457 @default.
• W4360992703 creator A5076872832 @default.
• W4360992703 creator A5079050618 @default.
• W4360992703 date "2023-03-27" @default.
• W4360992703 modified "2023-10-15" @default.
• W4360992703 title "Discovery of Bis-5-cyclopropylisoxazole-4-carboxamides as Novel Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors" @default.
• W4360992703 cites W2067478074 @default.
• W4360992703 cites W2321667681 @default.
• W4360992703 cites W2414740201 @default.
• W4360992703 cites W2554161387 @default.
• W4360992703 cites W2947947601 @default.
• W4360992703 cites W2959300394 @default.
• W4360992703 cites W2969652906 @default.
• W4360992703 cites W2980289225 @default.
• W4360992703 cites W3034495733 @default.
• W4360992703 cites W3111740362 @default.
• W4360992703 cites W3120273106 @default.
• W4360992703 cites W3161594854 @default.
• W4360992703 cites W3201791183 @default.
• W4360992703 cites W3207415891 @default.
• W4360992703 cites W3208115201 @default.
• W4360992703 cites W4212835215 @default.
• W4360992703 cites W4213071321 @default.
• W4360992703 cites W4214855940 @default.
• W4360992703 cites W4225003137 @default.
• W4360992703 cites W4249645390 @default.
• W4360992703 cites W4281829675 @default.
• W4360992703 cites W4281913293 @default.
• W4360992703 cites W4285726222 @default.
• W4360992703 cites W4285734029 @default.
• W4360992703 cites W4285999510 @default.
• W4360992703 cites W4286489728 @default.
• W4360992703 cites W4296665196 @default.
• W4360992703 cites W4297964536 @default.
• W4360992703 cites W4313544480 @default.
• W4360992703 doi "https://doi.org/10.1021/acs.jafc.2c08912" @default.
• W4360992703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36972477" @default.
• W4360992703 hasPublicationYear "2023" @default.
• W4360992703 type Work @default.
• W4360992703 citedByCount "0" @default.
• W4360992703 crossrefType "journal-article" @default.
• W4360992703 hasAuthorship W4360992703A5022475239 @default.
• W4360992703 hasAuthorship W4360992703A5037824478 @default.
• W4360992703 hasAuthorship W4360992703A5042036814 @default.
• W4360992703 hasAuthorship W4360992703A5043489457 @default.
• W4360992703 hasAuthorship W4360992703A5076872832 @default.
• W4360992703 hasAuthorship W4360992703A5079050618 @default.
• W4360992703 hasConcept C111919701 @default.
• W4360992703 hasConcept C169760540 @default.
• W4360992703 hasConcept C17077164 @default.
• W4360992703 hasConcept C181199279 @default.
• W4360992703 hasConcept C185592680 @default.
• W4360992703 hasConcept C202751555 @default.
• W4360992703 hasConcept C2775891814 @default.
• W4360992703 hasConcept C2776154959 @default.
• W4360992703 hasConcept C2776834422 @default.
• W4360992703 hasConcept C2777752112 @default.
• W4360992703 hasConcept C2780557392 @default.
• W4360992703 hasConcept C41008148 @default.
• W4360992703 hasConcept C55493867 @default.
• W4360992703 hasConcept C59822182 @default.
• W4360992703 hasConcept C71240020 @default.
• W4360992703 hasConcept C86803240 @default.
• W4360992703 hasConceptScore W4360992703C111919701 @default.
• W4360992703 hasConceptScore W4360992703C169760540 @default.
• W4360992703 hasConceptScore W4360992703C17077164 @default.
• W4360992703 hasConceptScore W4360992703C181199279 @default.
• W4360992703 hasConceptScore W4360992703C185592680 @default.
• W4360992703 hasConceptScore W4360992703C202751555 @default.
• W4360992703 hasConceptScore W4360992703C2775891814 @default.
• W4360992703 hasConceptScore W4360992703C2776154959 @default.
• W4360992703 hasConceptScore W4360992703C2776834422 @default.
• W4360992703 hasConceptScore W4360992703C2777752112 @default.
• W4360992703 hasConceptScore W4360992703C2780557392 @default.
• W4360992703 hasConceptScore W4360992703C41008148 @default.
• W4360992703 hasConceptScore W4360992703C55493867 @default.
• W4360992703 hasConceptScore W4360992703C59822182 @default.
• W4360992703 hasConceptScore W4360992703C71240020 @default.
• W4360992703 hasConceptScore W4360992703C86803240 @default.
• W4360992703 hasFunder F4320321001 @default.
• W4360992703 hasIssue "13" @default.
• W4360992703 hasLocation W43609927031 @default.
• W4360992703 hasLocation W43609927032 @default.
• W4360992703 hasOpenAccess W4360992703 @default.
• W4360992703 hasPrimaryLocation W43609927031 @default.
• W4360992703 hasRelatedWork W2032136268 @default.
• W4360992703 hasRelatedWork W2039384914 @default.
• W4360992703 hasRelatedWork W2047534689 @default.
• W4360992703 hasRelatedWork W2055463589 @default.
• W4360992703 hasRelatedWork W2095231879 @default.
• W4360992703 hasRelatedWork W2172540347 @default.
• W4360992703 hasRelatedWork W2214037558 @default.
• W4360992703 hasRelatedWork W2885104721 @default.

• next