Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360992788> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4360992788 abstract "Exosomes (sEVs) are extracellular vesicles involved in the pathogenesis of obesity. Notably, exosomal microRNAs (miRNAs) have emerged as crucial mediators of communication between cells and are involved in the development of obesity. One region of the brain known to be dysregulated in obesity is the hypothalamus. It coordinates whole-body energy homeostasis through stimulation and inhibition of the orexigenic neuropeptide (NPY)/agouti-related peptide (AgRP) neurons and anorexigenic proopiomelanocortin (POMC) neurons. A role for hypothalamic astrocytic exosomes in communication with POMC neurons was previously elucidated. Yet, it was unknown whether NPY/AgRP neurons secreted exosomes. We previously established that the saturated fat palmitate alters the intracellular levels of miRNAs and we now questioned whether palmitate would also alter the miRNA content of exosomal miRNAs. We found that the mHypoE-46 cell line secreted particles consistent with the size of exosomes and that palmitate altered levels of a spectrum of miRNAs associated with exosomes. The predicted KEGG pathways of the collective miRNA predicted targets included fatty acid metabolism and type II diabetes mellitus. Of note, one of these altered secreted miRNAs was miR-2137, which was also altered within the cells. We also found that while sEVs collected from the mHypoE-46 neurons increased Pomc mRNA in the mHypoA-POMC/GFP-2 cells after 48 h, the effect was absent with sEVs isolated following palmitate treatment, indicating another potential route by which palmitate promotes obesity. Hypothalamic neuronal exosomes may therefore play a role in the control of energy homeostasis that may be disrupted in obese conditions." @default.
- W4360992788 created "2023-03-30" @default.
- W4360992788 creator A5006143007 @default.
- W4360992788 creator A5064771046 @default.
- W4360992788 creator A5068447176 @default.
- W4360992788 creator A5068488174 @default.
- W4360992788 date "2023-03-01" @default.
- W4360992788 modified "2023-10-18" @default.
- W4360992788 title "Metástasis axilar de carcinoma epidermoide cutáneo" @default.
- W4360992788 doi "https://doi.org/10.1016/j.ciresp.2023.02.011" @default.
- W4360992788 hasPublicationYear "2023" @default.
- W4360992788 type Work @default.
- W4360992788 citedByCount "0" @default.
- W4360992788 crossrefType "journal-article" @default.
- W4360992788 hasAuthorship W4360992788A5006143007 @default.
- W4360992788 hasAuthorship W4360992788A5064771046 @default.
- W4360992788 hasAuthorship W4360992788A5068447176 @default.
- W4360992788 hasAuthorship W4360992788A5068488174 @default.
- W4360992788 hasConcept C104317684 @default.
- W4360992788 hasConcept C118303440 @default.
- W4360992788 hasConcept C126322002 @default.
- W4360992788 hasConcept C134018914 @default.
- W4360992788 hasConcept C145059251 @default.
- W4360992788 hasConcept C170493617 @default.
- W4360992788 hasConcept C20518536 @default.
- W4360992788 hasConcept C2491326 @default.
- W4360992788 hasConcept C2777003273 @default.
- W4360992788 hasConcept C2777205416 @default.
- W4360992788 hasConcept C2777391703 @default.
- W4360992788 hasConcept C2779306644 @default.
- W4360992788 hasConcept C3018667095 @default.
- W4360992788 hasConcept C55493867 @default.
- W4360992788 hasConcept C71924100 @default.
- W4360992788 hasConcept C86803240 @default.
- W4360992788 hasConcept C93984277 @default.
- W4360992788 hasConcept C95444343 @default.
- W4360992788 hasConceptScore W4360992788C104317684 @default.
- W4360992788 hasConceptScore W4360992788C118303440 @default.
- W4360992788 hasConceptScore W4360992788C126322002 @default.
- W4360992788 hasConceptScore W4360992788C134018914 @default.
- W4360992788 hasConceptScore W4360992788C145059251 @default.
- W4360992788 hasConceptScore W4360992788C170493617 @default.
- W4360992788 hasConceptScore W4360992788C20518536 @default.
- W4360992788 hasConceptScore W4360992788C2491326 @default.
- W4360992788 hasConceptScore W4360992788C2777003273 @default.
- W4360992788 hasConceptScore W4360992788C2777205416 @default.
- W4360992788 hasConceptScore W4360992788C2777391703 @default.
- W4360992788 hasConceptScore W4360992788C2779306644 @default.
- W4360992788 hasConceptScore W4360992788C3018667095 @default.
- W4360992788 hasConceptScore W4360992788C55493867 @default.
- W4360992788 hasConceptScore W4360992788C71924100 @default.
- W4360992788 hasConceptScore W4360992788C86803240 @default.
- W4360992788 hasConceptScore W4360992788C93984277 @default.
- W4360992788 hasConceptScore W4360992788C95444343 @default.
- W4360992788 hasLocation W43609927881 @default.
- W4360992788 hasOpenAccess W4360992788 @default.
- W4360992788 hasPrimaryLocation W43609927881 @default.
- W4360992788 hasRelatedWork W1966733155 @default.
- W4360992788 hasRelatedWork W1981396719 @default.
- W4360992788 hasRelatedWork W1981897232 @default.
- W4360992788 hasRelatedWork W2007165650 @default.
- W4360992788 hasRelatedWork W2037738117 @default.
- W4360992788 hasRelatedWork W2073107509 @default.
- W4360992788 hasRelatedWork W2080251505 @default.
- W4360992788 hasRelatedWork W2101303909 @default.
- W4360992788 hasRelatedWork W2107263774 @default.
- W4360992788 hasRelatedWork W2147404772 @default.
- W4360992788 isParatext "false" @default.
- W4360992788 isRetracted "false" @default.
- W4360992788 workType "article" @default.