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• W4360999615 startingPage "111062" @default.
• W4360999615 abstract "In inflammatory bowel disease (IBD), tissue damage and cell death occur, which are accompanied by the release of DNA into the extracellular space. Deoxyribonucleases (DNases) are enzymes that cleave phosphodiester bonds in DNA. Exogenous DNases have anti-inflammatory effects in animal models. It is not known whether endogenous DNase activity can affect the pathogenesis of IBD. Herein we hypothesize that lower DNase activity found in the distal colon compared with proximal parts of the gastrointestinal tract could be partially responsible for the limited localization of ulcerative colitis to distal parts of the gastrointestinal tract and contribute to the ineffective removal of pro-inflammatory extracellular DNA. Hypothesis testing was performed on homogenates of individual parts of the gastrointestinal tract, in which endogenous DNase activity and its change after addition of DNase as a therapeutic were measured. A more accurate determination of DNase activity in individual gastrointestinal regions and uncovering the unknown DNase inhibitors in the colon could help to optimize the preparation of targeted therapeutics for IBD. Localized exogenous delivery of DNases to cleave extracellular DNA and eliminate inflammation could thus represent an effective supplementary therapy." @default.
• W4360999615 created "2023-03-30" @default.
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• W4360999615 date "2023-05-01" @default.
• W4360999615 modified "2023-10-16" @default.
• W4360999615 title "Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis" @default.
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• W4360999615 doi "https://doi.org/10.1016/j.mehy.2023.111062" @default.
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