FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4360999948> ?p ?o ?g. }

• W4360999948 endingPage "147390" @default.
• W4360999948 startingPage "147390" @default.
• W4360999948 abstract "Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to identify new therapeutic approaches to overcome HCC. One of the vital signaling pathways in organ homeostasis and male sexual development is Androgen Receptor (AR) signaling. Its activity affects several genes that contribute to cancer characteristics and have essential roles in cell cycle progression, proliferation, angiogenesis, and metastasis. AR signaling has been shown to be misregulated in many cancers, including HCC, suggesting that it might contribute to hepatocarcinogenesis. Targeting AR signaling using anti-androgens, AR inhibitors, or AR-degrading molecules is a powerful and promising strategy to defeat HCC. In this study, AR signaling was targeted by a novel Selective Androgen Receptor Modulator (SARM), S4, in HCC cells to evaluate its potential anti-cancer effect. To date, S4 activity in cancer has not been demonstrated, and our data unrevealed that S4 significantly impaired HCC growth, migration, proliferation, and induced apoptosis through inhibiting PI3K/AKT/mTOR signaling. Since PI3K/AKT/mTOR signaling is frequently activated in HCC and contributes to its aggressiveness and poor prognosis, its negative regulation by the downregulation of critical components via S4 was a prominent finding. Further studies are necessary to investigate the S4 action mechanism and anti-tumorigenic capacity in in-vivo." @default.
• W4360999948 created "2023-03-30" @default.
• W4360999948 creator A5001692156 @default.
• W4360999948 creator A5007343951 @default.
• W4360999948 creator A5027823241 @default.
• W4360999948 creator A5073226644 @default.
• W4360999948 date "2023-06-01" @default.
• W4360999948 modified "2023-10-18" @default.
• W4360999948 title "A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway" @default.
• W4360999948 cites W1553270930 @default.
• W4360999948 cites W196749151 @default.
• W4360999948 cites W1976559240 @default.
• W4360999948 cites W1980330982 @default.
• W4360999948 cites W1988337666 @default.
• W4360999948 cites W1990132124 @default.
• W4360999948 cites W1991430905 @default.
• W4360999948 cites W2004590033 @default.
• W4360999948 cites W2009429082 @default.
• W4360999948 cites W2010558905 @default.
• W4360999948 cites W2018317782 @default.
• W4360999948 cites W2029560072 @default.
• W4360999948 cites W2029683042 @default.
• W4360999948 cites W2039845199 @default.
• W4360999948 cites W2043830388 @default.
• W4360999948 cites W2044093708 @default.
• W4360999948 cites W2045115988 @default.
• W4360999948 cites W2046056065 @default.
• W4360999948 cites W2046891574 @default.
• W4360999948 cites W2053114150 @default.
• W4360999948 cites W2055887835 @default.
• W4360999948 cites W2073460053 @default.
• W4360999948 cites W2088095756 @default.
• W4360999948 cites W2089069885 @default.
• W4360999948 cites W2091376176 @default.
• W4360999948 cites W2092515164 @default.
• W4360999948 cites W2117502057 @default.
• W4360999948 cites W2127102078 @default.
• W4360999948 cites W2140854888 @default.
• W4360999948 cites W2143926802 @default.
• W4360999948 cites W2162242700 @default.
• W4360999948 cites W2162723598 @default.
• W4360999948 cites W2262929177 @default.
• W4360999948 cites W2412843427 @default.
• W4360999948 cites W2572010783 @default.
• W4360999948 cites W2770010368 @default.
• W4360999948 cites W2770290981 @default.
• W4360999948 cites W2771940085 @default.
• W4360999948 cites W2796210129 @default.
• W4360999948 cites W2804573802 @default.
• W4360999948 cites W2806421539 @default.
• W4360999948 cites W2808774195 @default.
• W4360999948 cites W2888103445 @default.
• W4360999948 cites W2903095656 @default.
• W4360999948 cites W2945508549 @default.
• W4360999948 cites W2947893479 @default.
• W4360999948 cites W2950764390 @default.
• W4360999948 cites W2980546791 @default.
• W4360999948 cites W2987478061 @default.
• W4360999948 cites W2991597369 @default.
• W4360999948 cites W2994604855 @default.
• W4360999948 cites W3005327400 @default.
• W4360999948 cites W3006230832 @default.
• W4360999948 cites W3009624272 @default.
• W4360999948 cites W3011014170 @default.
• W4360999948 cites W3021610682 @default.
• W4360999948 cites W3027074191 @default.
• W4360999948 cites W3029313038 @default.
• W4360999948 cites W3035610439 @default.
• W4360999948 cites W3040461816 @default.
• W4360999948 cites W3047525736 @default.
• W4360999948 cites W3076978218 @default.
• W4360999948 cites W3091905674 @default.
• W4360999948 cites W3096333099 @default.
• W4360999948 cites W3099276507 @default.
• W4360999948 cites W3109004530 @default.
• W4360999948 cites W3112297212 @default.
• W4360999948 cites W3130005770 @default.
• W4360999948 cites W3166798421 @default.
• W4360999948 cites W3193057927 @default.
• W4360999948 cites W3201272122 @default.
• W4360999948 cites W3210270108 @default.
• W4360999948 cites W3213378938 @default.
• W4360999948 cites W4210774372 @default.
• W4360999948 cites W4233675068 @default.
• W4360999948 cites W4282939499 @default.
• W4360999948 cites W4307558518 @default.
• W4360999948 cites W4307820787 @default.
• W4360999948 cites W4308868774 @default.
• W4360999948 cites W4309046074 @default.
• W4360999948 cites W4315754108 @default.
• W4360999948 doi "https://doi.org/10.1016/j.gene.2023.147390" @default.
• W4360999948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36990257" @default.
• W4360999948 hasPublicationYear "2023" @default.
• W4360999948 type Work @default.
• W4360999948 citedByCount "1" @default.
• W4360999948 countsByYear W43609999482023 @default.
• W4360999948 crossrefType "journal-article" @default.
• W4360999948 hasAuthorship W4360999948A5001692156 @default.

• next