FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361001038> ?p ?o ?g. }

• W4361001038 abstract "Abstract Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling. Defining the molecular mechanism that underpins this metabolic programming will have direct significance for patients with PCa who have a poor prognosis. Here we show that there is a dynamic balance between sortilin and syndecan-1, that reports on different metabolic phenotypes. Using tissue microarrays, we demonstrated by immunohistochemistry that sortilin was highly expressed in low-grade cancer, while syndecan-1 was upregulated in high-grade disease. Mechanistic studies in prostate cell lines (selected to match the biomarker phenotypes in tissue from PCa patients) revealed that in androgen-sensitive LNCaP cells, sortilin enhanced glucose metabolism by regulating GLUT1 and GLUT4, while binding progranulin and lipoprotein lipase (LPL) to limit lipid metabolism. In contrast, in androgen-insensitive PC3 cells, syndecan-1 was upregulated, interacted with LPL and colocalised with β 3 integrin to promote lipid metabolism. In addition, androgen-deprived LNCaP cells had decreased expression of sortilin and reduced glucose-metabolism, but increased syndecan-1 expression, facilitating interactions with LPL and possibly β 3 integrin. We report a hitherto unappreciated molecular mechanism for PCa, which has significance for disease progression and how androgen-deprivation therapy may promote castration-resistant PCa." @default.
• W4361001038 created "2023-03-30" @default.
• W4361001038 creator A5004220786 @default.
• W4361001038 creator A5010108130 @default.
• W4361001038 creator A5011486833 @default.
• W4361001038 creator A5023652398 @default.
• W4361001038 creator A5025498124 @default.
• W4361001038 creator A5026230487 @default.
• W4361001038 creator A5028387712 @default.
• W4361001038 creator A5031137727 @default.
• W4361001038 creator A5031790108 @default.
• W4361001038 creator A5032213369 @default.
• W4361001038 creator A5032903954 @default.
• W4361001038 creator A5036372545 @default.
• W4361001038 creator A5038236602 @default.
• W4361001038 creator A5040263941 @default.
• W4361001038 creator A5040947740 @default.
• W4361001038 creator A5041422863 @default.
• W4361001038 creator A5041493693 @default.
• W4361001038 creator A5043621658 @default.
• W4361001038 creator A5045558392 @default.
• W4361001038 creator A5046079650 @default.
• W4361001038 creator A5047909615 @default.
• W4361001038 creator A5050015095 @default.
• W4361001038 creator A5050075947 @default.
• W4361001038 creator A5052635659 @default.
• W4361001038 creator A5057671717 @default.
• W4361001038 creator A5068715453 @default.
• W4361001038 creator A5070856432 @default.
• W4361001038 creator A5071705623 @default.
• W4361001038 date "2023-03-27" @default.
• W4361001038 modified "2023-10-16" @default.
• W4361001038 title "Dynamic interplay between sortilin and syndecan-1 drives a metabolic switch during prostate cancer progression" @default.
• W4361001038 cites W1753864465 @default.
• W4361001038 cites W1919512980 @default.
• W4361001038 cites W1997964633 @default.
• W4361001038 cites W2018734911 @default.
• W4361001038 cites W2036802778 @default.
• W4361001038 cites W2048388437 @default.
• W4361001038 cites W2057689789 @default.
• W4361001038 cites W2064737300 @default.
• W4361001038 cites W2082418977 @default.
• W4361001038 cites W2117594441 @default.
• W4361001038 cites W2150737519 @default.
• W4361001038 cites W2159321716 @default.
• W4361001038 cites W2166816242 @default.
• W4361001038 cites W2328671688 @default.
• W4361001038 cites W2330709458 @default.
• W4361001038 cites W2335526641 @default.
• W4361001038 cites W2344000214 @default.
• W4361001038 cites W2606998714 @default.
• W4361001038 cites W2752803806 @default.
• W4361001038 cites W2767305686 @default.
• W4361001038 cites W2785632856 @default.
• W4361001038 cites W2789890745 @default.
• W4361001038 cites W2884071076 @default.
• W4361001038 cites W2905589155 @default.
• W4361001038 cites W2946732916 @default.
• W4361001038 cites W2964989731 @default.
• W4361001038 cites W2965768671 @default.
• W4361001038 cites W2974507377 @default.
• W4361001038 cites W2974971672 @default.
• W4361001038 cites W2991442221 @default.
• W4361001038 cites W3024731698 @default.
• W4361001038 cites W3029335085 @default.
• W4361001038 cites W3035860319 @default.
• W4361001038 cites W3044935695 @default.
• W4361001038 cites W3095753974 @default.
• W4361001038 cites W3098736162 @default.
• W4361001038 cites W3107527779 @default.
• W4361001038 cites W3128646645 @default.
• W4361001038 cites W3129693773 @default.
• W4361001038 cites W3185237874 @default.
• W4361001038 cites W4297725718 @default.
• W4361001038 cites W590084404 @default.
• W4361001038 doi "https://doi.org/10.21203/rs.3.rs-2693853/v1" @default.
• W4361001038 hasPublicationYear "2023" @default.
• W4361001038 type Work @default.
• W4361001038 citedByCount "0" @default.
• W4361001038 crossrefType "posted-content" @default.
• W4361001038 hasAuthorship W4361001038A5004220786 @default.
• W4361001038 hasAuthorship W4361001038A5010108130 @default.
• W4361001038 hasAuthorship W4361001038A5011486833 @default.
• W4361001038 hasAuthorship W4361001038A5023652398 @default.
• W4361001038 hasAuthorship W4361001038A5025498124 @default.
• W4361001038 hasAuthorship W4361001038A5026230487 @default.
• W4361001038 hasAuthorship W4361001038A5028387712 @default.
• W4361001038 hasAuthorship W4361001038A5031137727 @default.
• W4361001038 hasAuthorship W4361001038A5031790108 @default.
• W4361001038 hasAuthorship W4361001038A5032213369 @default.
• W4361001038 hasAuthorship W4361001038A5032903954 @default.
• W4361001038 hasAuthorship W4361001038A5036372545 @default.
• W4361001038 hasAuthorship W4361001038A5038236602 @default.
• W4361001038 hasAuthorship W4361001038A5040263941 @default.
• W4361001038 hasAuthorship W4361001038A5040947740 @default.
• W4361001038 hasAuthorship W4361001038A5041422863 @default.
• W4361001038 hasAuthorship W4361001038A5041493693 @default.
• W4361001038 hasAuthorship W4361001038A5043621658 @default.
• W4361001038 hasAuthorship W4361001038A5045558392 @default.
• W4361001038 hasAuthorship W4361001038A5046079650 @default.

• next